FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124704805> ?p ?o ?g. }

• W2124704805 endingPage "e0142588" @default.
• W2124704805 startingPage "e0142588" @default.
• W2124704805 abstract "Advances in cancer treatment utilizing multiple chemotherapies have dramatically increased cancer survivorship. Female cancer survivors treated with doxorubicin (DXR) chemotherapy often suffer from an acute impairment of ovarian function, which can persist as long-term, permanent ovarian insufficiency. Dexrazoxane (Dexra) pretreatment reduces DXR-induced insult in the heart, and protects in vitro cultured murine and non-human primate ovaries, demonstrating a drug-based shield to prevent DXR insult. The present study tested the ability of Dexra pretreatment to mitigate acute DXR chemotherapy ovarian toxicity in mice through the first 24 hours post-treatment, and improve subsequent long-term fertility throughout the reproductive lifespan. Adolescent CD-1 mice were treated with Dexra 1 hour prior to DXR treatment in a 1:1 mg or 10:1 mg Dexra:DXR ratio. During the acute injury period (2–24 hours post-injection), Dexra pretreatment at a 1:1 mg ratio decreased the extent of double strand DNA breaks, diminished γH2FAX activation, and reduced subsequent follicular cellular demise caused by DXR. In fertility and fecundity studies, dams pretreated with either Dexra:DXR dose ratio exhibited litter sizes larger than DXR-treated dams, and mice treated with a 1:1 mg Dexra:DXR ratio delivered pups with birth weights greater than DXR-treated females. While DXR significantly increased the “infertility index” (quantifying the percentage of dams failing to achieve pregnancy) through 6 gestations following treatment, Dexra pretreatment significantly reduced the infertility index following DXR treatment, improving fecundity. Low dose Dexra not only protected the ovaries, but also bestowed a considerable survival advantage following exposure to DXR chemotherapy. Mouse survivorship increased from 25% post-DXR treatment to over 80% with Dexra pretreatment. These data demonstrate that Dexra provides acute ovarian protection from DXR toxicity, improving reproductive health in a mouse model, suggesting this clinically available drug may provide ovarian protection for cancer patients." @default.
• W2124704805 created "2016-06-24" @default.
• W2124704805 creator A5011737196 @default.
• W2124704805 creator A5038078105 @default.
• W2124704805 creator A5044156215 @default.
• W2124704805 creator A5055004911 @default.
• W2124704805 creator A5070241693 @default.
• W2124704805 creator A5083253733 @default.
• W2124704805 date "2015-11-06" @default.
• W2124704805 modified "2023-10-07" @default.
• W2124704805 title "Dexrazoxane Diminishes Doxorubicin-Induced Acute Ovarian Damage and Preserves Ovarian Function and Fecundity in Mice" @default.
• W2124704805 cites W1518374878 @default.
• W2124704805 cites W1570743730 @default.
• W2124704805 cites W1760708290 @default.
• W2124704805 cites W1833330468 @default.
• W2124704805 cites W1867963032 @default.
• W2124704805 cites W1894009312 @default.
• W2124704805 cites W1957304651 @default.
• W2124704805 cites W1965380539 @default.
• W2124704805 cites W1967051016 @default.
• W2124704805 cites W1967234305 @default.
• W2124704805 cites W1973252291 @default.
• W2124704805 cites W1981531462 @default.
• W2124704805 cites W1981932258 @default.
• W2124704805 cites W1983824622 @default.
• W2124704805 cites W1985060248 @default.
• W2124704805 cites W1990419569 @default.
• W2124704805 cites W1990918362 @default.
• W2124704805 cites W1991540594 @default.
• W2124704805 cites W1992121166 @default.
• W2124704805 cites W1992437129 @default.
• W2124704805 cites W2000155615 @default.
• W2124704805 cites W2010183849 @default.
• W2124704805 cites W2015574813 @default.
• W2124704805 cites W2020391016 @default.
• W2124704805 cites W2020904943 @default.
• W2124704805 cites W2031421067 @default.
• W2124704805 cites W2035774287 @default.
• W2124704805 cites W2036225919 @default.
• W2124704805 cites W2037145686 @default.
• W2124704805 cites W2037977021 @default.
• W2124704805 cites W2043339266 @default.
• W2124704805 cites W2056254035 @default.
• W2124704805 cites W2056363035 @default.
• W2124704805 cites W2056624091 @default.
• W2124704805 cites W2059514724 @default.
• W2124704805 cites W2059565914 @default.
• W2124704805 cites W2063169831 @default.
• W2124704805 cites W2070005495 @default.
• W2124704805 cites W2072220114 @default.
• W2124704805 cites W2074257515 @default.
• W2124704805 cites W2074934283 @default.
• W2124704805 cites W2088996917 @default.
• W2124704805 cites W2091613175 @default.
• W2124704805 cites W2097331847 @default.
• W2124704805 cites W2099615704 @default.
• W2124704805 cites W2100912472 @default.
• W2124704805 cites W2106926141 @default.
• W2124704805 cites W2112357840 @default.
• W2124704805 cites W2120261037 @default.
• W2124704805 cites W2128587010 @default.
• W2124704805 cites W2134260774 @default.
• W2124704805 cites W2134748828 @default.
• W2124704805 cites W2135215861 @default.
• W2124704805 cites W2142075003 @default.
• W2124704805 cites W2146035745 @default.
• W2124704805 cites W2151686920 @default.
• W2124704805 cites W2162878054 @default.
• W2124704805 cites W2167824292 @default.
• W2124704805 cites W2225859329 @default.
• W2124704805 cites W2240540152 @default.
• W2124704805 cites W2272821227 @default.
• W2124704805 cites W2335283150 @default.
• W2124704805 cites W2589617459 @default.
• W2124704805 cites W4249430888 @default.
• W2124704805 cites W4255236038 @default.
• W2124704805 doi "https://doi.org/10.1371/journal.pone.0142588" @default.
• W2124704805 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4636352" @default.
• W2124704805 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26544188" @default.
• W2124704805 hasPublicationYear "2015" @default.
• W2124704805 type Work @default.
• W2124704805 sameAs 2124704805 @default.
• W2124704805 citedByCount "31" @default.
• W2124704805 countsByYear W21247048052016 @default.
• W2124704805 countsByYear W21247048052017 @default.
• W2124704805 countsByYear W21247048052018 @default.
• W2124704805 countsByYear W21247048052019 @default.
• W2124704805 countsByYear W21247048052020 @default.
• W2124704805 countsByYear W21247048052021 @default.
• W2124704805 countsByYear W21247048052023 @default.
• W2124704805 crossrefType "journal-article" @default.
• W2124704805 hasAuthorship W2124704805A5011737196 @default.
• W2124704805 hasAuthorship W2124704805A5038078105 @default.
• W2124704805 hasAuthorship W2124704805A5044156215 @default.
• W2124704805 hasAuthorship W2124704805A5055004911 @default.
• W2124704805 hasAuthorship W2124704805A5070241693 @default.
• W2124704805 hasAuthorship W2124704805A5083253733 @default.
• W2124704805 hasBestOaLocation W21247048051 @default.

• next