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• W2124706579 abstract "Streptococcus pneumoniae sortase A (SrtA) is a transpeptidase that is highly conserved among pneumococcal strains, whose involvement in adhesion/colonization has been reported. We found that intraperitoneal immunization with recombinant SrtA conferred to mice protection against S. pneumoniae intraperitoneal challenge and that the passive transfer of immune serum before intraperitoneal challenge was also protective. Moreover, by using the intranasal challenge model, we observed a significant reduction of bacteremia when mice were intraperitoneally immunized with SrtA, while a moderate decrease of lung infection was achieved by intranasal immunization, even though no influence on nasopharynx colonization was seen. Taken together, our results suggest that SrtA is a good candidate for inclusion in a multicomponent, protein-based, pneumococcal vaccine." @default.
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• W2124706579 date "2009-07-01" @default.
• W2124706579 modified "2023-10-18" @default.
• W2124706579 title "Sortase A Confers Protection against <i>Streptococcus pneumoniae</i> in Mice" @default.
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• W2124706579 doi "https://doi.org/10.1128/iai.01516-08" @default.
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