FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124710135> ?p ?o ?g. }

• W2124710135 endingPage "193" @default.
• W2124710135 startingPage "187" @default.
• W2124710135 abstract "Ionizing radiation has been used to treat cancers for a century. However, radioresistance remains a major problem in the clinic. Recent advances in the understanding of the molecular events that occur following ionizing radiation leading to DNA damage and repair, apoptosis, and cell cycle arrests suggest new ways in which the radiation response might be manipulated. Seventy-eight cases of carcinoma of the cervix of the same stage (II A and B) were analyzed retrospectively. All patients were treated with radiotherapy (RT) with a dose varying from 35 Gy to 50 Gy with 200 cGy per fraction. Subsequent to the completion of radiotherapy, all patients underwent surgery 4-6 weeks later. On histological examination of the surgical specimens, 51% of the cases (40) showed a complete response to therapy with no viable tumor cells. 49% of cases (38) had residual tumors ranging from a small focus to lesions extending through more than half the thickness of the cervical wall. p53 (mutant), bcl-2, p21 and bax proteins were studied on the paraffin sections of the biopsies (pretreatment) of those patients who failed to respond to RT and compared to similar studies on biopsies of patients who had a complete response to RT. In addition, the minichromosome maintenance (MCM) 2 proliferative marker was also done on all cases. Expression of all proteins was done using immunohistochemsitry. In the radioresistant cases, 15% (six cases) showed positivity for bcl-2 and p21, respectively, and 34% (13 cases) showed mutant p53. None of the radiosensitive tumors were positive for the above proteins. 75% of the radiosensitive tumors (30 cases) were positive for the bax antibody, whereas 81% of the radioresistant tumors (31 cases) were negative for bax. The MCM2 proliferative marker was positive in > 80% of cells in 81.5% of radioresistant tumors (31 cases) as compared to < 40% of cells that were positive in 70% of radiosensitive tumors (28 cases). The P-value for the biological markers was calculated using the chi-squared test, and was highly significant (P < 0.01) for all the parameters tested. However, there was no statistical significance by univariate analysis when the dose of radiation was analyzed with respect to the markers and the histological response. There was also no correlation between the radiation response and timing of surgery. The above data strongly suggest that bax, along with proliferative markers, could play a role in determining which tumors are likely to respond to radiation therapy. The presence of bcl-2, p21 and p53 could also be related to radioresistance of the tumors." @default.
• W2124710135 created "2016-06-24" @default.
• W2124710135 creator A5028615603 @default.
• W2124710135 creator A5033301881 @default.
• W2124710135 creator A5034354958 @default.
• W2124710135 creator A5037639185 @default.
• W2124710135 creator A5047452420 @default.
• W2124710135 creator A5049593624 @default.
• W2124710135 creator A5051562152 @default.
• W2124710135 creator A5052236281 @default.
• W2124710135 creator A5057904305 @default.
• W2124710135 creator A5067577559 @default.
• W2124710135 date "2001-05-08" @default.
• W2124710135 modified "2023-10-17" @default.
• W2124710135 title "Biologic factors and response to radiotherapy in carcinoma of the cervix" @default.
• W2124710135 cites W1512539933 @default.
• W2124710135 cites W1824579594 @default.
• W2124710135 cites W1976570855 @default.
• W2124710135 cites W1981153827 @default.
• W2124710135 cites W1984873483 @default.
• W2124710135 cites W1993177852 @default.
• W2124710135 cites W1997778522 @default.
• W2124710135 cites W2000772826 @default.
• W2124710135 cites W2001095597 @default.
• W2124710135 cites W2001479945 @default.
• W2124710135 cites W2003282728 @default.
• W2124710135 cites W2003555214 @default.
• W2124710135 cites W2005479501 @default.
• W2124710135 cites W2015519364 @default.
• W2124710135 cites W2030394499 @default.
• W2124710135 cites W2031328498 @default.
• W2124710135 cites W2032141702 @default.
• W2124710135 cites W2037528907 @default.
• W2124710135 cites W2041027497 @default.
• W2124710135 cites W2045879436 @default.
• W2124710135 cites W2048428832 @default.
• W2124710135 cites W2050090012 @default.
• W2124710135 cites W2054452888 @default.
• W2124710135 cites W2064508977 @default.
• W2124710135 cites W2079701410 @default.
• W2124710135 cites W2089218510 @default.
• W2124710135 cites W2090157013 @default.
• W2124710135 cites W2093571646 @default.
• W2124710135 cites W2098033418 @default.
• W2124710135 cites W2129781454 @default.
• W2124710135 cites W2141190082 @default.
• W2124710135 cites W2170085122 @default.
• W2124710135 cites W2486700304 @default.
• W2124710135 cites W4245446268 @default.
• W2124710135 cites W4323966455 @default.
• W2124710135 doi "https://doi.org/10.1046/j.1525-1438.2001.01014.x" @default.
• W2124710135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11437923" @default.
• W2124710135 hasPublicationYear "2001" @default.
• W2124710135 type Work @default.
• W2124710135 sameAs 2124710135 @default.
• W2124710135 citedByCount "41" @default.
• W2124710135 countsByYear W21247101352012 @default.
• W2124710135 countsByYear W21247101352013 @default.
• W2124710135 countsByYear W21247101352015 @default.
• W2124710135 countsByYear W21247101352018 @default.
• W2124710135 countsByYear W21247101352019 @default.
• W2124710135 countsByYear W21247101352020 @default.
• W2124710135 countsByYear W21247101352023 @default.
• W2124710135 crossrefType "journal-article" @default.
• W2124710135 hasAuthorship W2124710135A5028615603 @default.
• W2124710135 hasAuthorship W2124710135A5033301881 @default.
• W2124710135 hasAuthorship W2124710135A5034354958 @default.
• W2124710135 hasAuthorship W2124710135A5037639185 @default.
• W2124710135 hasAuthorship W2124710135A5047452420 @default.
• W2124710135 hasAuthorship W2124710135A5049593624 @default.
• W2124710135 hasAuthorship W2124710135A5051562152 @default.
• W2124710135 hasAuthorship W2124710135A5052236281 @default.
• W2124710135 hasAuthorship W2124710135A5057904305 @default.
• W2124710135 hasAuthorship W2124710135A5067577559 @default.
• W2124710135 hasConcept C111337013 @default.
• W2124710135 hasConcept C121332964 @default.
• W2124710135 hasConcept C121608353 @default.
• W2124710135 hasConcept C126322002 @default.
• W2124710135 hasConcept C126838900 @default.
• W2124710135 hasConcept C142724271 @default.
• W2124710135 hasConcept C18231593 @default.
• W2124710135 hasConcept C185544564 @default.
• W2124710135 hasConcept C206684579 @default.
• W2124710135 hasConcept C2777546739 @default.
• W2124710135 hasConcept C2777740455 @default.
• W2124710135 hasConcept C502942594 @default.
• W2124710135 hasConcept C509974204 @default.
• W2124710135 hasConcept C58962609 @default.
• W2124710135 hasConcept C71924100 @default.
• W2124710135 hasConceptScore W2124710135C111337013 @default.
• W2124710135 hasConceptScore W2124710135C121332964 @default.
• W2124710135 hasConceptScore W2124710135C121608353 @default.
• W2124710135 hasConceptScore W2124710135C126322002 @default.
• W2124710135 hasConceptScore W2124710135C126838900 @default.
• W2124710135 hasConceptScore W2124710135C142724271 @default.
• W2124710135 hasConceptScore W2124710135C18231593 @default.
• W2124710135 hasConceptScore W2124710135C185544564 @default.
• W2124710135 hasConceptScore W2124710135C206684579 @default.

• next