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• W2124712366 abstract "Antibody responses to citrullinated self-proteins are found in autoimmunities, particularly in rheumatoid arthritis, where they serve as a diagnostic indicator. We show here that processing of the protein hen egg-white lysozyme (HEL) resulted in citrullination of peptides presented on class II MHC molecules by antigen-presenting cells. The presentation of the citrullinated peptides but not of the unmodified peptides was associated with autophagy. Dendritic cells (DCs), macrophages, and thymic DCs presented citrullinated peptides constitutively. Their treatment with 3-methyladenine (3MA) blocked presentation of citrullinated HEL peptides, but presentation of unmodified peptides was not affected. Presentation of citrullinated peptides was not detected on B cells or B lymphoma cells under normal culture conditions. In B cells, engagement of the B cell antigen receptor was required for presentation of the citrullinated peptides, also inhibited by 3MA. B lymphoma-expressing HEL cells presented citrullinated peptides only after brief serum starvation. This presentation was reduced by 3MA or by reduction in Atg5 expression. Presentation of the unmodified peptides was not changed. The findings indicate a linkage between autophagy and autoreactivity through the generation of this neo-epitope." @default.
• W2124712366 created "2016-06-24" @default.
• W2124712366 creator A5017122117 @default.
• W2124712366 creator A5079811330 @default.
• W2124712366 date "2011-12-12" @default.
• W2124712366 modified "2023-10-06" @default.
• W2124712366 title "Autophagy in antigen-presenting cells results in presentation of citrullinated peptides to CD4 T cells" @default.
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• W2124712366 doi "https://doi.org/10.1084/jem.20110640" @default.
• W2124712366 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3244027" @default.
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• W2124712366 hasPublicationYear "2011" @default.
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