FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124759152> ?p ?o ?g. }

• W2124759152 endingPage "51" @default.
• W2124759152 startingPage "43" @default.
• W2124759152 abstract "To describe the rationale, technique, and early results of stereotactically guided conformal radiotherapy (SCRT) in the treatment of progressive or inoperable low-grade gliomas (LGGs) of childhood.Between September 1994 and May 1999, 14 children (median age 6 years, range 5-16) with LGG were treated with SCRT at the Royal Marsden NHS Trust. Tumors were located at the optic chiasm (n = 9), third ventricle (n = 2), hypothalamus, craniocervical junction, and pineal region (each n = 1). Four patients received chemotherapy before SCRT. Immobilization was in a Gill-Thomas-Cosman frame (n = 12) and subsequently in a specially designed pediatric version of the frame (n = 2). Stereotactic coordinates and the tumor were defined by CT scanning with a fiducial system and MRI fusion. The median tumor volume was 19.5 cm(3) (range 7.5-180). The planning target volume was defined as the area of enhancing tumor plus a 5-10-mm margin. The treatment technique consisted of 4 isocentric, noncoplanar, conformal, fixed fields. Treatment was delivered in 30-33 daily fractions to a total dose of 50-55 Gy.SCRT was well tolerated, with transient hair loss the only acute toxicity. The median follow-up was 33 months (range 2-53). At 6 months after SCRT, 4 of 12 children with neurologic deficits improved and 5 remained stable. Twelve children were available for MRI evaluation. Two had a complete response, 6 a partial response, and 4 stable disease. One child with optic chiasm glioma had local progression at 25 months, and 1 developed diffuse leptomeningeal disease without local progression at 27 months. The 3-year local progression-free survival and overall survival rate after SCRT was 87% and 100%, respectively, compared with 89% and 98% for an historic control treated with conventional RT. New endocrine deficiencies were noted in 2 children after a follow-up of 20 and 23 months.SCRT is a feasible, high-precision technique of RT for children with LGGs for whom RT is considered appropriate. The local control and acute toxicity of SCRT are comparable to a historic control of patients with conventionally delivered RT. The frequency of delayed hypothalamic-pituitary axis dysfunction reflects tumor location adjacent to the hypothalamus and pituitary. Additional follow-up is required to demonstrate that SCRT contributes to a reduction in treatment-related late toxicity, while maintaining the local control achieved with conventionally delivered RT in children with progressive LGGs." @default.
• W2124759152 created "2016-06-24" @default.
• W2124759152 creator A5011770259 @default.
• W2124759152 creator A5044767725 @default.
• W2124759152 creator A5047879448 @default.
• W2124759152 creator A5057893360 @default.
• W2124759152 creator A5069505091 @default.
• W2124759152 creator A5079004439 @default.
• W2124759152 creator A5080362183 @default.
• W2124759152 date "2002-05-01" @default.
• W2124759152 modified "2023-10-17" @default.
• W2124759152 title "Stereotactically guided conformal radiotherapy for progressive low-grade gliomas of childhood" @default.
• W2124759152 cites W1819030526 @default.
• W2124759152 cites W1976674434 @default.
• W2124759152 cites W1982680560 @default.
• W2124759152 cites W1989395448 @default.
• W2124759152 cites W1990146497 @default.
• W2124759152 cites W1990635499 @default.
• W2124759152 cites W1999157018 @default.
• W2124759152 cites W2003391946 @default.
• W2124759152 cites W2006812243 @default.
• W2124759152 cites W2009957442 @default.
• W2124759152 cites W2010912142 @default.
• W2124759152 cites W2014818783 @default.
• W2124759152 cites W2020425634 @default.
• W2124759152 cites W2022807308 @default.
• W2124759152 cites W2030171190 @default.
• W2124759152 cites W2039957621 @default.
• W2124759152 cites W2055928489 @default.
• W2124759152 cites W2062104635 @default.
• W2124759152 cites W2063278239 @default.
• W2124759152 cites W2066907256 @default.
• W2124759152 cites W2067388373 @default.
• W2124759152 cites W2069064354 @default.
• W2124759152 cites W2069637023 @default.
• W2124759152 cites W2076555208 @default.
• W2124759152 cites W2079874384 @default.
• W2124759152 cites W2085111388 @default.
• W2124759152 cites W2085959790 @default.
• W2124759152 cites W2088178265 @default.
• W2124759152 cites W2098353832 @default.
• W2124759152 cites W2124187900 @default.
• W2124759152 cites W2131726538 @default.
• W2124759152 cites W2143505528 @default.
• W2124759152 cites W2162407965 @default.
• W2124759152 cites W2164662532 @default.
• W2124759152 cites W3021935720 @default.
• W2124759152 cites W4299613077 @default.
• W2124759152 doi "https://doi.org/10.1016/s0360-3016(02)02734-7" @default.
• W2124759152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12007940" @default.
• W2124759152 hasPublicationYear "2002" @default.
• W2124759152 type Work @default.
• W2124759152 sameAs 2124759152 @default.
• W2124759152 citedByCount "88" @default.
• W2124759152 countsByYear W21247591522012 @default.
• W2124759152 countsByYear W21247591522013 @default.
• W2124759152 countsByYear W21247591522014 @default.
• W2124759152 countsByYear W21247591522015 @default.
• W2124759152 countsByYear W21247591522016 @default.
• W2124759152 countsByYear W21247591522017 @default.
• W2124759152 countsByYear W21247591522018 @default.
• W2124759152 countsByYear W21247591522019 @default.
• W2124759152 countsByYear W21247591522020 @default.
• W2124759152 countsByYear W21247591522021 @default.
• W2124759152 countsByYear W21247591522022 @default.
• W2124759152 countsByYear W21247591522023 @default.
• W2124759152 crossrefType "journal-article" @default.
• W2124759152 hasAuthorship W2124759152A5011770259 @default.
• W2124759152 hasAuthorship W2124759152A5044767725 @default.
• W2124759152 hasAuthorship W2124759152A5047879448 @default.
• W2124759152 hasAuthorship W2124759152A5057893360 @default.
• W2124759152 hasAuthorship W2124759152A5069505091 @default.
• W2124759152 hasAuthorship W2124759152A5079004439 @default.
• W2124759152 hasAuthorship W2124759152A5080362183 @default.
• W2124759152 hasConcept C118487528 @default.
• W2124759152 hasConcept C126322002 @default.
• W2124759152 hasConcept C126838900 @default.
• W2124759152 hasConcept C141071460 @default.
• W2124759152 hasConcept C142724271 @default.
• W2124759152 hasConcept C2776694085 @default.
• W2124759152 hasConcept C2779797997 @default.
• W2124759152 hasConcept C2780387249 @default.
• W2124759152 hasConcept C2780789225 @default.
• W2124759152 hasConcept C2780837183 @default.
• W2124759152 hasConcept C2781171461 @default.
• W2124759152 hasConcept C2989005 @default.
• W2124759152 hasConcept C509974204 @default.
• W2124759152 hasConcept C71924100 @default.
• W2124759152 hasConceptScore W2124759152C118487528 @default.
• W2124759152 hasConceptScore W2124759152C126322002 @default.
• W2124759152 hasConceptScore W2124759152C126838900 @default.
• W2124759152 hasConceptScore W2124759152C141071460 @default.
• W2124759152 hasConceptScore W2124759152C142724271 @default.
• W2124759152 hasConceptScore W2124759152C2776694085 @default.
• W2124759152 hasConceptScore W2124759152C2779797997 @default.
• W2124759152 hasConceptScore W2124759152C2780387249 @default.
• W2124759152 hasConceptScore W2124759152C2780789225 @default.
• W2124759152 hasConceptScore W2124759152C2780837183 @default.

• next