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- W2124766730 abstract "Reports of cutaneous photosensitivity to new pharmaceutical agents appear almost every year.<sup>1,2</sup>Among drugs causing photosensitivity, nonsteroidal inflammatory drugs (NSAIDs) stand out: first, because they are reported on more frequently than other types of drugs, and second, because of the incongruity that agents designed to inhibit inflammation actually cause light-initiated inflammation. Why are many NSAIDs photosensitizing? Is it just an odd coincidence or is a specific mechanism responsible? Most of the NSAIDs causing photosensitivity are phenylpropionic acid derivatives: benoxaprofen,<sup>3-7</sup>carprofen,<sup>8</sup>ketoprofen,<sup>9</sup>tiaprofenic acid,<sup>10</sup>and naproxen.<sup>10</sup>In this issue of theArchives, Kaidby and Mitchell<sup>11</sup>extend this list to a new NSAID, nabumetone, in their report on experimentally induced phototoxicity to propionic acid-derivative NSAIDs in volunteers. The cutaneous photosensitivity to NSAIDs appears to be elicited by a phototoxicity mechanism. The response is immediate (within minutes of exposure to ultraviolet [UV] radiation) for benoxaprofen, naproxen," @default.
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- W2124766730 date "1989-06-01" @default.
- W2124766730 modified "2023-10-04" @default.
- W2124766730 title "Phototoxicity of nonsteroidal inflammatory drugs. Coincidence or specific mechanism?" @default.
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- W2124766730 doi "https://doi.org/10.1001/archderm.125.6.824" @default.
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