FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124769266> ?p ?o ?g. }

• W2124769266 endingPage "939" @default.
• W2124769266 startingPage "932" @default.
• W2124769266 abstract "Abstract Vascular endothelial growth factor (VEGF) has traditionally been considered an endothelial cell–specific factor inducing angiogenesis and vascular permeability in vivo. In the present study, expression of VEGF and its receptors, fetal liver kinase-1 (flk-1) and fms -like tyrosine kinase-1 (flt-1), was examined in rat carotid arteries after balloon injury. Although VEGF and flk-1 were not detectable, high levels of flt-1 mRNA and protein were expressed by smooth muscle cells (SMCs) in the neointima, as demonstrated by en face in situ hybridization and Western blotting. Intimal SMC proliferation in chronically denuded rat carotid arteries was unaffected by intraluminal infusion of VEGF, whereas fibroblast growth factor (FGF)-2 increased the number of replicating SMCs 4-fold. Pretreatment with VEGF doubled the mitogenic response to infused FGF-2 by increasing SMC replication in deeper layers of the intima. VEGF increased the permeability of chronically denuded vessels to plasma proteins but had no effect on the uptake of locally infused biotinylated FGF-2. These findings demonstrate that vascular SMCs express functional flt-1 receptors after arterial injury and that VEGF has synergistic effects with FGF-2 on SMC proliferation. These effects are likely to be mediated by a VEGF-mediated increase in permeability as well as a direct interaction between the VEGF and FGF signaling pathways." @default.
• W2124769266 created "2016-06-24" @default.
• W2124769266 creator A5060838998 @default.
• W2124769266 creator A5064027212 @default.
• W2124769266 creator A5068388118 @default.
• W2124769266 creator A5068808545 @default.
• W2124769266 creator A5073942058 @default.
• W2124769266 date "1997-12-01" @default.
• W2124769266 modified "2023-09-26" @default.
• W2124769266 title "Vascular Endothelial Growth Factor Increases the Mitogenic Response to Fibroblast Growth Factor-2 in Vascular Smooth Muscle Cells In Vivo via Expression of <i>fms-</i> Like Tyrosine Kinase-1" @default.
• W2124769266 cites W1670891845 @default.
• W2124769266 cites W1957871175 @default.
• W2124769266 cites W1960517479 @default.
• W2124769266 cites W1964068703 @default.
• W2124769266 cites W1967004211 @default.
• W2124769266 cites W1971248512 @default.
• W2124769266 cites W1975662136 @default.
• W2124769266 cites W1980755389 @default.
• W2124769266 cites W1986469266 @default.
• W2124769266 cites W1987644022 @default.
• W2124769266 cites W1991958278 @default.
• W2124769266 cites W1993487598 @default.
• W2124769266 cites W1996890384 @default.
• W2124769266 cites W2003598961 @default.
• W2124769266 cites W2010092400 @default.
• W2124769266 cites W2017627019 @default.
• W2124769266 cites W2022036429 @default.
• W2124769266 cites W2023453327 @default.
• W2124769266 cites W2043863730 @default.
• W2124769266 cites W2045247659 @default.
• W2124769266 cites W2046451608 @default.
• W2124769266 cites W2049827480 @default.
• W2124769266 cites W2050358495 @default.
• W2124769266 cites W2051692310 @default.
• W2124769266 cites W2054255117 @default.
• W2124769266 cites W2084506573 @default.
• W2124769266 cites W2093498435 @default.
• W2124769266 cites W2114659469 @default.
• W2124769266 cites W2202356825 @default.
• W2124769266 cites W2409596512 @default.
• W2124769266 cites W2414769601 @default.
• W2124769266 cites W4294216491 @default.
• W2124769266 doi "https://doi.org/10.1161/01.res.81.6.932" @default.
• W2124769266 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9400373" @default.
• W2124769266 hasPublicationYear "1997" @default.
• W2124769266 type Work @default.
• W2124769266 sameAs 2124769266 @default.
• W2124769266 citedByCount "81" @default.
• W2124769266 countsByYear W21247692662012 @default.
• W2124769266 countsByYear W21247692662013 @default.
• W2124769266 countsByYear W21247692662014 @default.
• W2124769266 countsByYear W21247692662015 @default.
• W2124769266 countsByYear W21247692662016 @default.
• W2124769266 countsByYear W21247692662017 @default.
• W2124769266 countsByYear W21247692662019 @default.
• W2124769266 countsByYear W21247692662022 @default.
• W2124769266 countsByYear W21247692662023 @default.
• W2124769266 crossrefType "journal-article" @default.
• W2124769266 hasAuthorship W2124769266A5060838998 @default.
• W2124769266 hasAuthorship W2124769266A5064027212 @default.
• W2124769266 hasAuthorship W2124769266A5068388118 @default.
• W2124769266 hasAuthorship W2124769266A5068808545 @default.
• W2124769266 hasAuthorship W2124769266A5073942058 @default.
• W2124769266 hasConcept C113045295 @default.
• W2124769266 hasConcept C126322002 @default.
• W2124769266 hasConcept C134018914 @default.
• W2124769266 hasConcept C146285616 @default.
• W2124769266 hasConcept C15215337 @default.
• W2124769266 hasConcept C167734588 @default.
• W2124769266 hasConcept C170493617 @default.
• W2124769266 hasConcept C2777025900 @default.
• W2124769266 hasConcept C2777339539 @default.
• W2124769266 hasConcept C2778283817 @default.
• W2124769266 hasConcept C2778583881 @default.
• W2124769266 hasConcept C2779395532 @default.
• W2124769266 hasConcept C2780394083 @default.
• W2124769266 hasConcept C2992686903 @default.
• W2124769266 hasConcept C42362537 @default.
• W2124769266 hasConcept C502942594 @default.
• W2124769266 hasConcept C62478195 @default.
• W2124769266 hasConcept C71924100 @default.
• W2124769266 hasConcept C74373430 @default.
• W2124769266 hasConcept C86803240 @default.
• W2124769266 hasConcept C95444343 @default.
• W2124769266 hasConceptScore W2124769266C113045295 @default.
• W2124769266 hasConceptScore W2124769266C126322002 @default.
• W2124769266 hasConceptScore W2124769266C134018914 @default.
• W2124769266 hasConceptScore W2124769266C146285616 @default.
• W2124769266 hasConceptScore W2124769266C15215337 @default.
• W2124769266 hasConceptScore W2124769266C167734588 @default.
• W2124769266 hasConceptScore W2124769266C170493617 @default.
• W2124769266 hasConceptScore W2124769266C2777025900 @default.
• W2124769266 hasConceptScore W2124769266C2777339539 @default.
• W2124769266 hasConceptScore W2124769266C2778283817 @default.
• W2124769266 hasConceptScore W2124769266C2778583881 @default.
• W2124769266 hasConceptScore W2124769266C2779395532 @default.
• W2124769266 hasConceptScore W2124769266C2780394083 @default.
• W2124769266 hasConceptScore W2124769266C2992686903 @default.

• next