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• W2124772005 abstract "Abstract: In synaptosomes prepared from rat cerebral cortex, free cytosolic calcium concentration ([Ca 2+ ] i ) was measured using the fluorescent dye fura‐2, Incubation of fura‐2‐loaded synaptosomes with carbachol increased [Ca 2+ ] i in a dose‐dependent manner (1–1,000 μ M ), with a maximum response of 22 × 2% at approximately 100 μ M and an EC 50 (calculated concentration producing 50% of the maximum response) of 30 μ M The effect of carbachol (100 μ M ) on [Ca 2+ ], was antagonised by atropine, but not by hexamethonium (10 μ M ). The calculated concentration of atropine needed for 50% inhibition (IC 50 ) was 260 n M. The rise in [Ca 2+ ] i produced by carbachol was reduced in the absence of extrasynaptosomal Ca 2+ and effectively blocked by the L‐type calcium channel blocker nifedipine (with an IC 50 of 29 n M ). The response to carbachol was reduced if the synaptosomes were preincubated with the protein kinase inhibitors H7 [1‐(5‐isoquinolinylsulfonyl)‐2‐methylpiperazine] (from 17% in the solvent control to 4%) and staurosporine (from 20% in the solvent control to 3%). These results show that stimulation of muscarinic acetylcholine receptors in synaptosomes increases [Ca 2+ ] i by protein kinase‐dependent activation of 1,4‐dihydropyridinesensitive calcium channels." @default.
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• W2124772005 date "1990-07-01" @default.
• W2124772005 modified "2023-10-11" @default.
• W2124772005 title "Stimulation of Muscarinic Acetylcholine Receptors Increases Synaptosomal Free Calcium Concentration by Protein Kinase‐Dependent Opening of L‐Type Calcium Channels" @default.
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• W2124772005 doi "https://doi.org/10.1111/j.1471-4159.1990.tb08843.x" @default.
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