FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124774927> ?p ?o ?g. }

• W2124774927 endingPage "270" @default.
• W2124774927 startingPage "253" @default.
• W2124774927 abstract "The zebrafish has become an important model organism to study myelination during development and after a lesion of the adult central nervous system (CNS). Here, we identify Claudin k as a myelin-associated protein in zebrafish and determine its localization during development and adult optic nerve regeneration. We find Claudin k in subcellular compartments consistent with location in autotypic tight junctions of oligodendrocytes and myelinating Schwann cells. Expression starts in the hindbrain at 2 days (mRNA) and 3 days (protein) postfertilization and is maintained in adults. A newly generated claudin k:green fluorescent protein (GFP) reporter line allowed us to characterize oligodendrocytes in the adult retina that express Claudin k and olig2, but not P0 and uniquely only form loose wraps of membrane around axons. After a crush of the adult optic nerve, Claudin k protein levels were first reduced and then recovered within 4 weeks postlesion, concomitant with optic nerve myelin de- and regeneration. During optic nerve regeneration, oligodendrocytes, many of which were newly generated, repopulated the lesion site and exhibited increasing morphological complexity over time. Thus, Claudin k is a novel myelin-associated protein expressed by oligodendrocytes and Schwann cells from early stages of wrapping and myelin formation in zebrafish development and adult regeneration, suggesting important functions of the gene for myelin formation and maintenance. Our Claudin k antibodies and claudin k:GFP reporter line represent excellent ways to visualize oligodendrocyte and Schwann cell differentiation in vivo. © 2011 Wiley Periodicals, Inc." @default.
• W2124774927 created "2016-06-24" @default.
• W2124774927 creator A5007503698 @default.
• W2124774927 creator A5009638418 @default.
• W2124774927 creator A5029256430 @default.
• W2124774927 creator A5045520159 @default.
• W2124774927 creator A5062316592 @default.
• W2124774927 creator A5065576952 @default.
• W2124774927 creator A5068065538 @default.
• W2124774927 creator A5081370735 @default.
• W2124774927 creator A5081747194 @default.
• W2124774927 creator A5084735777 @default.
• W2124774927 date "2011-10-21" @default.
• W2124774927 modified "2023-10-05" @default.
• W2124774927 title "Claudin k is specifically expressed in cells that form myelin during development of the nervous system and regeneration of the optic nerve in adult zebrafish" @default.
• W2124774927 cites W1485262693 @default.
• W2124774927 cites W1588714068 @default.
• W2124774927 cites W1600824865 @default.
• W2124774927 cites W1626699932 @default.
• W2124774927 cites W1952870715 @default.
• W2124774927 cites W1969821478 @default.
• W2124774927 cites W1973807758 @default.
• W2124774927 cites W1977635041 @default.
• W2124774927 cites W1978121032 @default.
• W2124774927 cites W1982509114 @default.
• W2124774927 cites W1987122345 @default.
• W2124774927 cites W1990936460 @default.
• W2124774927 cites W1992938999 @default.
• W2124774927 cites W1998198360 @default.
• W2124774927 cites W2001670939 @default.
• W2124774927 cites W2005578607 @default.
• W2124774927 cites W2005889545 @default.
• W2124774927 cites W2009766076 @default.
• W2124774927 cites W2011356699 @default.
• W2124774927 cites W2014294861 @default.
• W2124774927 cites W2016508121 @default.
• W2124774927 cites W2017655089 @default.
• W2124774927 cites W2019709994 @default.
• W2124774927 cites W2021834993 @default.
• W2124774927 cites W2025616602 @default.
• W2124774927 cites W2026511098 @default.
• W2124774927 cites W2042250021 @default.
• W2124774927 cites W2042472279 @default.
• W2124774927 cites W2043406861 @default.
• W2124774927 cites W2047669974 @default.
• W2124774927 cites W2048082433 @default.
• W2124774927 cites W2048303947 @default.
• W2124774927 cites W2049578737 @default.
• W2124774927 cites W2050638312 @default.
• W2124774927 cites W2051797386 @default.
• W2124774927 cites W2053881066 @default.
• W2124774927 cites W2055719111 @default.
• W2124774927 cites W2057798352 @default.
• W2124774927 cites W2062988576 @default.
• W2124774927 cites W2063260002 @default.
• W2124774927 cites W2070932367 @default.
• W2124774927 cites W2075900533 @default.
• W2124774927 cites W2078760188 @default.
• W2124774927 cites W2080069132 @default.
• W2124774927 cites W2082942373 @default.
• W2124774927 cites W2087435196 @default.
• W2124774927 cites W2092411481 @default.
• W2124774927 cites W2093315874 @default.
• W2124774927 cites W2095059094 @default.
• W2124774927 cites W2099636023 @default.
• W2124774927 cites W2102323023 @default.
• W2124774927 cites W2110998704 @default.
• W2124774927 cites W2126867710 @default.
• W2124774927 cites W2135728275 @default.
• W2124774927 cites W2140425784 @default.
• W2124774927 cites W2144857752 @default.
• W2124774927 cites W2150362899 @default.
• W2124774927 cites W2159247182 @default.
• W2124774927 cites W2164814636 @default.
• W2124774927 cites W2166884973 @default.
• W2124774927 cites W2168555450 @default.
• W2124774927 cites W2169820828 @default.
• W2124774927 cites W2399184589 @default.
• W2124774927 cites W2484659268 @default.
• W2124774927 cites W4242530862 @default.
• W2124774927 cites W4243653664 @default.
• W2124774927 doi "https://doi.org/10.1002/glia.21260" @default.
• W2124774927 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22020875" @default.
• W2124774927 hasPublicationYear "2011" @default.
• W2124774927 type Work @default.
• W2124774927 sameAs 2124774927 @default.
• W2124774927 citedByCount "79" @default.
• W2124774927 countsByYear W21247749272012 @default.
• W2124774927 countsByYear W21247749272013 @default.
• W2124774927 countsByYear W21247749272014 @default.
• W2124774927 countsByYear W21247749272015 @default.
• W2124774927 countsByYear W21247749272016 @default.
• W2124774927 countsByYear W21247749272017 @default.
• W2124774927 countsByYear W21247749272018 @default.
• W2124774927 countsByYear W21247749272019 @default.
• W2124774927 countsByYear W21247749272020 @default.
• W2124774927 countsByYear W21247749272021 @default.
• W2124774927 countsByYear W21247749272022 @default.

• next