FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124777183> ?p ?o ?g. }

• W2124777183 endingPage "1295" @default.
• W2124777183 startingPage "1285" @default.
• W2124777183 abstract "Metastasis is one of the most important factors related to breast cancer therapeutic efficacy. Ursolic acid, a naturally occurring triterpenoid, has various anticancer activities. In this study, we first observed that ursolic acid exerted a dose- and time-dependent inhibitory effect on the migration and invasion of highly metastatic breast MDAMB231 cells at non-cytotoxic concentrations. This effect was associated with reduced activities of metalloproteinase-2 (MMP-2) and u-PA, which correlated with enhanced expression of tissue inhibitor of MMP-2 and plasminogen activator inhibitor-1, respectively. Ursolic acid suppressed the phosphorylation of Jun N-terminal kinase, Akt and mammalian target of rapamycin, but had no effect on the phosphorylation of ERK and p38. Ursolic acid also strongly reduced the levels of NFkappaB p65, c-Jun and c-Fos proteins in the nucleus of MDAMB231 cells. A time-dependent inhibition of the protein levels of Rho-like GTPases, growth factor receptor-bound protein 2, Ras and vascular endothelial growth factor in cytosol by ursolic acid treatment was also observed. In conclusion, we demonstrated that the anti-invasive effects of ursolic acid on MDAMB231 cells might be through the inhibition of Jun N-terminal kinase, Akt and mammalian target of rapamycin phosphorylation and a reduction of the level of NFkappaB protein in the nucleus, ultimately leading to downregulation of MMP-2 and u-PA expression. These results suggest that ursolic acid has potential as a chemopreventive agent for metastatic breast cancer." @default.
• W2124777183 created "2016-06-24" @default.
• W2124777183 creator A5006041425 @default.
• W2124777183 creator A5022131769 @default.
• W2124777183 creator A5029670240 @default.
• W2124777183 date "2010-03-29" @default.
• W2124777183 modified "2023-10-06" @default.
• W2124777183 title "Ursolic acid, a naturally occurring triterpenoid, suppresses migration and invasion of human breast cancer cells by modulating c-Jun <i>N</i> -terminal kinase, Akt and mammalian target of rapamycin signaling" @default.
• W2124777183 cites W1507248692 @default.
• W2124777183 cites W1964361275 @default.
• W2124777183 cites W1964672896 @default.
• W2124777183 cites W1968131542 @default.
• W2124777183 cites W1968374269 @default.
• W2124777183 cites W1976697969 @default.
• W2124777183 cites W1978981032 @default.
• W2124777183 cites W1981406217 @default.
• W2124777183 cites W1985374049 @default.
• W2124777183 cites W1988620734 @default.
• W2124777183 cites W1998267950 @default.
• W2124777183 cites W2002423794 @default.
• W2124777183 cites W2010558905 @default.
• W2124777183 cites W2023438328 @default.
• W2124777183 cites W2024100842 @default.
• W2124777183 cites W2025686120 @default.
• W2124777183 cites W2034003932 @default.
• W2124777183 cites W2044505245 @default.
• W2124777183 cites W2056324134 @default.
• W2124777183 cites W2058635721 @default.
• W2124777183 cites W2058812654 @default.
• W2124777183 cites W2074433596 @default.
• W2124777183 cites W2074599278 @default.
• W2124777183 cites W2078333674 @default.
• W2124777183 cites W2093755380 @default.
• W2124777183 cites W2102998091 @default.
• W2124777183 cites W2103443377 @default.
• W2124777183 cites W2111205112 @default.
• W2124777183 cites W2145548823 @default.
• W2124777183 cites W2324787672 @default.
• W2124777183 doi "https://doi.org/10.1002/mnfr.200900414" @default.
• W2124777183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20352621" @default.
• W2124777183 hasPublicationYear "2010" @default.
• W2124777183 type Work @default.
• W2124777183 sameAs 2124777183 @default.
• W2124777183 citedByCount "100" @default.
• W2124777183 countsByYear W21247771832012 @default.
• W2124777183 countsByYear W21247771832013 @default.
• W2124777183 countsByYear W21247771832014 @default.
• W2124777183 countsByYear W21247771832015 @default.
• W2124777183 countsByYear W21247771832016 @default.
• W2124777183 countsByYear W21247771832017 @default.
• W2124777183 countsByYear W21247771832018 @default.
• W2124777183 countsByYear W21247771832019 @default.
• W2124777183 countsByYear W21247771832020 @default.
• W2124777183 countsByYear W21247771832021 @default.
• W2124777183 countsByYear W21247771832022 @default.
• W2124777183 countsByYear W21247771832023 @default.
• W2124777183 crossrefType "journal-article" @default.
• W2124777183 hasAuthorship W2124777183A5006041425 @default.
• W2124777183 hasAuthorship W2124777183A5022131769 @default.
• W2124777183 hasAuthorship W2124777183A5029670240 @default.
• W2124777183 hasConcept C104317684 @default.
• W2124777183 hasConcept C11960822 @default.
• W2124777183 hasConcept C184235292 @default.
• W2124777183 hasConcept C185592680 @default.
• W2124777183 hasConcept C2779087070 @default.
• W2124777183 hasConcept C2779513101 @default.
• W2124777183 hasConcept C43617362 @default.
• W2124777183 hasConcept C502942594 @default.
• W2124777183 hasConcept C55493867 @default.
• W2124777183 hasConcept C62478195 @default.
• W2124777183 hasConcept C75217442 @default.
• W2124777183 hasConcept C86339819 @default.
• W2124777183 hasConcept C86803240 @default.
• W2124777183 hasConcept C98274493 @default.
• W2124777183 hasConceptScore W2124777183C104317684 @default.
• W2124777183 hasConceptScore W2124777183C11960822 @default.
• W2124777183 hasConceptScore W2124777183C184235292 @default.
• W2124777183 hasConceptScore W2124777183C185592680 @default.
• W2124777183 hasConceptScore W2124777183C2779087070 @default.
• W2124777183 hasConceptScore W2124777183C2779513101 @default.
• W2124777183 hasConceptScore W2124777183C43617362 @default.
• W2124777183 hasConceptScore W2124777183C502942594 @default.
• W2124777183 hasConceptScore W2124777183C55493867 @default.
• W2124777183 hasConceptScore W2124777183C62478195 @default.
• W2124777183 hasConceptScore W2124777183C75217442 @default.
• W2124777183 hasConceptScore W2124777183C86339819 @default.
• W2124777183 hasConceptScore W2124777183C86803240 @default.
• W2124777183 hasConceptScore W2124777183C98274493 @default.
• W2124777183 hasIssue "9" @default.
• W2124777183 hasLocation W21247771831 @default.
• W2124777183 hasLocation W21247771832 @default.
• W2124777183 hasOpenAccess W2124777183 @default.
• W2124777183 hasPrimaryLocation W21247771831 @default.
• W2124777183 hasRelatedWork W1911507086 @default.
• W2124777183 hasRelatedWork W1974268113 @default.
• W2124777183 hasRelatedWork W1994403682 @default.
• W2124777183 hasRelatedWork W2006105451 @default.
• W2124777183 hasRelatedWork W2101634100 @default.

• next