Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124807260> ?p ?o ?g. }
- W2124807260 endingPage "6767" @default.
- W2124807260 startingPage "6758" @default.
- W2124807260 abstract "Influenza virus nucleoprotein (NP) is the major component of the viral ribonucleoprotein complex, which is crucial for the transcription and replication of the viral genome. We have determined the crystal structure of influenza B virus NP to a resolution of 3.2 Å. Influenza B NP contains a head, a body domain, and a tail loop. The electropositive groove between the head and body domains of influenza B NP is crucial for RNA binding. This groove also contains an extended flexible charged loop (amino acids [aa] 125 to 149), and two lysine clusters at the first half of this loop were shown to be crucial for binding RNA. Influenza B virus NP forms a crystallographic homotetramer by inserting the tail loop into the body domain of the neighboring NP molecule. A deeply buried salt bridge between R472 and E395 and a hydrophobic cluster at F468 are the major driving forces for the insertion. The analysis of the influenza B virus NP structure and function and comparisons with influenza A virus NP provide insights into the mechanisms of action and underpin efforts to design inhibitors for this class of proteins." @default.
- W2124807260 created "2016-06-24" @default.
- W2124807260 creator A5006030795 @default.
- W2124807260 creator A5032269228 @default.
- W2124807260 creator A5051255494 @default.
- W2124807260 creator A5054536677 @default.
- W2124807260 creator A5054714447 @default.
- W2124807260 creator A5054736166 @default.
- W2124807260 creator A5069738454 @default.
- W2124807260 creator A5073744778 @default.
- W2124807260 date "2012-06-15" @default.
- W2124807260 modified "2023-09-26" @default.
- W2124807260 title "Structural Basis for RNA Binding and Homo-Oligomer Formation by Influenza B Virus Nucleoprotein" @default.
- W2124807260 cites W1505403902 @default.
- W2124807260 cites W1539796472 @default.
- W2124807260 cites W1605151536 @default.
- W2124807260 cites W1802723320 @default.
- W2124807260 cites W1973063795 @default.
- W2124807260 cites W1974714329 @default.
- W2124807260 cites W1974962646 @default.
- W2124807260 cites W1978402752 @default.
- W2124807260 cites W1978448113 @default.
- W2124807260 cites W1986191025 @default.
- W2124807260 cites W1989392795 @default.
- W2124807260 cites W1996783000 @default.
- W2124807260 cites W1998555563 @default.
- W2124807260 cites W2021527318 @default.
- W2124807260 cites W2026616872 @default.
- W2124807260 cites W2034573447 @default.
- W2124807260 cites W2045112588 @default.
- W2124807260 cites W2047267761 @default.
- W2124807260 cites W2074338162 @default.
- W2124807260 cites W2075023587 @default.
- W2124807260 cites W2096507556 @default.
- W2124807260 cites W2105403271 @default.
- W2124807260 cites W2112410398 @default.
- W2124807260 cites W2112790267 @default.
- W2124807260 cites W2114415472 @default.
- W2124807260 cites W2120034417 @default.
- W2124807260 cites W2124026197 @default.
- W2124807260 cites W2144680438 @default.
- W2124807260 cites W2159074870 @default.
- W2124807260 cites W2165459383 @default.
- W2124807260 cites W2180229411 @default.
- W2124807260 doi "https://doi.org/10.1128/jvi.00073-12" @default.
- W2124807260 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3393550" @default.
- W2124807260 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22496219" @default.
- W2124807260 hasPublicationYear "2012" @default.
- W2124807260 type Work @default.
- W2124807260 sameAs 2124807260 @default.
- W2124807260 citedByCount "56" @default.
- W2124807260 countsByYear W21248072602012 @default.
- W2124807260 countsByYear W21248072602013 @default.
- W2124807260 countsByYear W21248072602014 @default.
- W2124807260 countsByYear W21248072602015 @default.
- W2124807260 countsByYear W21248072602016 @default.
- W2124807260 countsByYear W21248072602017 @default.
- W2124807260 countsByYear W21248072602018 @default.
- W2124807260 countsByYear W21248072602019 @default.
- W2124807260 countsByYear W21248072602020 @default.
- W2124807260 countsByYear W21248072602021 @default.
- W2124807260 countsByYear W21248072602022 @default.
- W2124807260 countsByYear W21248072602023 @default.
- W2124807260 crossrefType "journal-article" @default.
- W2124807260 hasAuthorship W2124807260A5006030795 @default.
- W2124807260 hasAuthorship W2124807260A5032269228 @default.
- W2124807260 hasAuthorship W2124807260A5051255494 @default.
- W2124807260 hasAuthorship W2124807260A5054536677 @default.
- W2124807260 hasAuthorship W2124807260A5054714447 @default.
- W2124807260 hasAuthorship W2124807260A5054736166 @default.
- W2124807260 hasAuthorship W2124807260A5069738454 @default.
- W2124807260 hasAuthorship W2124807260A5073744778 @default.
- W2124807260 hasBestOaLocation W21248072601 @default.
- W2124807260 hasConcept C104317684 @default.
- W2124807260 hasConcept C138885662 @default.
- W2124807260 hasConcept C140704245 @default.
- W2124807260 hasConcept C159047783 @default.
- W2124807260 hasConcept C179926584 @default.
- W2124807260 hasConcept C2522874641 @default.
- W2124807260 hasConcept C2777546802 @default.
- W2124807260 hasConcept C2781416681 @default.
- W2124807260 hasConcept C41895202 @default.
- W2124807260 hasConcept C54355233 @default.
- W2124807260 hasConcept C552990157 @default.
- W2124807260 hasConcept C60325843 @default.
- W2124807260 hasConcept C67705224 @default.
- W2124807260 hasConcept C75934600 @default.
- W2124807260 hasConcept C82381507 @default.
- W2124807260 hasConcept C86295872 @default.
- W2124807260 hasConcept C86803240 @default.
- W2124807260 hasConceptScore W2124807260C104317684 @default.
- W2124807260 hasConceptScore W2124807260C138885662 @default.
- W2124807260 hasConceptScore W2124807260C140704245 @default.
- W2124807260 hasConceptScore W2124807260C159047783 @default.
- W2124807260 hasConceptScore W2124807260C179926584 @default.
- W2124807260 hasConceptScore W2124807260C2522874641 @default.
- W2124807260 hasConceptScore W2124807260C2777546802 @default.
- W2124807260 hasConceptScore W2124807260C2781416681 @default.