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• W2124811111 endingPage "999" @default.
• W2124811111 startingPage "985" @default.
• W2124811111 abstract "DNA damage by ultraviolet (UV) light poses a risk for mutagenesis and a potential hindrance for cell cycle progression. Cells cope with UV-induced DNA damage through two general strategies to repair the damaged nucleotides and to promote cell cycle progression in the presence of UV-damaged DNA. Defining the genetic pathways and understanding how they function together to enable effective tolerance to UV remains an important area of research. The structural maintenance of chromosomes (SMC) proteins form distinct complexes that maintain genome stability during chromosome segregation, homologous recombination, and DNA replication. Using a forward genetic screen, we identified two alleles of smc-5 that exacerbate UV sensitivity in Caenorhabditis elegans. Germ cells of smc-5-defective animals show reduced proliferation, sensitivity to perturbed replication, chromatin bridge formation, and accumulation of RAD-51 foci that indicate the activation of homologous recombination at DNA double-strand breaks. Mutations in the translesion synthesis polymerase polh-1 act synergistically with smc-5 mutations in provoking genome instability after UV-induced DNA damage. In contrast, the DNA damage accumulation and sensitivity of smc-5 mutant strains to replication impediments are suppressed by mutations in the C. elegans BRCA1/BARD1 homologs, brc-1 and brd-1. We propose that SMC-5/6 promotes replication fork stability and facilitates recombination-dependent repair when the BRC-1/BRD-1 complex initiates homologous recombination at stalled replication forks. Our data suggest that BRC-1/BRD-1 can both promote and antagonize genome stability depending on whether homologous recombination is initiated during DNA double-strand break repair or during replication stalling." @default.
• W2124811111 created "2016-06-24" @default.
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• W2124811111 date "2014-04-01" @default.
• W2124811111 modified "2023-10-18" @default.
• W2124811111 title "Loss of<i>Caenorhabditis elegans</i>BRCA1 Promotes Genome Stability During Replication in<i>smc-5</i>Mutants" @default.
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• W2124811111 doi "https://doi.org/10.1534/genetics.113.158295" @default.
• W2124811111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3982690" @default.
• W2124811111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24424777" @default.
• W2124811111 hasPublicationYear "2014" @default.
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