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• W2124830463 abstract "Purpose: To determine the response rate (RR) and survival produced by carboplatin + gemcitabine therapy in patients with untreated extensive small cell lung cancer (ESCLC). Patients and methods: Treatment consisted of carboplatin (AUC = 5) on day 1 and gemcitabine (1100 mg/m2) on days 1 and 8 of each 21-day cycle for 4 planned cycles (additional cycles allowed as per treating physician). ECOG performance status 0/1/2 was 29, 58, and 13%. Median age was 66.5 years (range: 41.3–83.1), 94% were white, and 50.7% were female. Results: Between August 2000 and February 2002, 69 patients with ESCLC were enrolled. All 69 patients were included in the safety analysis, and 66 patients were evaluable for response. There were 2 CR (3.0%), 26 PR (39.5%), 23 SD (34.8%), and 15 PD (22.7%) resulting in a RR of 42.5%. The median survival was 9.2 months (range: <1–22.6), and the estimated 1-year survival was 33%. The median TTP was 3.9 months (range: <1–12.8), and the estimated 6-month progression free survival was 24%. The median duration of response was 3.8 months (range: 1.0–9.9). Out of 69 patients, 29, 3, and 16 received 4, 5, and 6 cycles of therapy, respectively. The major Grade 3, 4 toxicities included neutropenia (39.1%), thrombocytopenia (31.9%), anemia (13.0%), and fatigue (4.3%). Conclusion: This regimen resulted in survival data that was similar to other regimens for ESCLC and treatment appeared to be well tolerated. Gemcitabine in combination with carboplatin or other active drugs in ESCLC may be worth further investigation." @default.
• W2124830463 created "2016-06-24" @default.
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• W2124830463 date "2004-12-01" @default.
• W2124830463 modified "2023-09-26" @default.
• W2124830463 title "Results of a Phase II study of carboplatin plus gemcitabine in patients with untreated extensive small cell lung cancer" @default.
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• W2124830463 doi "https://doi.org/10.1016/j.lungcan.2004.05.006" @default.
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