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• W2124865173 startingPage "125" @default.
• W2124865173 abstract "The hypocretins (Hcrts, also known as orexins) are two peptides, both synthesized by a small group of neurons, most of which are in the lateral hypothalamic and perifornical regions of the hypothalamus. The hypothalamic Hcrt system directly and strongly innervates and potently excites noradrenergic, dopaminergic, serotonergic, histaminergic, and cholinergic neurons. Hcrt also has a major role in modulating the release of glutamate and other amino acid transmitters. Behavioral investigations have revealed that Hcrt is released at high levels in active waking and rapid eye movement (REM) sleep and at minimal levels in non-REM sleep. Hcrt release in waking is increased markedly during periods of increased motor activity relative to levels in quiet, alert waking. Evidence for a role for Hcrt in food intake regulation is inconsistent. I hypothesize that Hcrt's major role is to facilitate motor activity tonically and phasically in association with motivated behaviors and to coordinate this facilitation with the activation of attentional and sensory systems. Degeneration of Hcrt neurons or genetic mutations that prevent the normal synthesis of Hcrt or of its receptors causes human and animal narcolepsy. Narcolepsy is characterized by an impaired ability to maintain alertness for long periods and by sudden losses of muscle tone (cataplexy). Administration of Hcrt can reverse symptoms of narcolepsy in animals, may be effective in treating human narcolepsy, and may affect a broad range of motivated behaviors." @default.
• W2124865173 created "2016-06-24" @default.
• W2124865173 creator A5070736314 @default.
• W2124865173 date "2004-02-01" @default.
• W2124865173 modified "2023-10-01" @default.
• W2124865173 title "Hypocretin (OREXIN): Role in Normal Behavior and Neuropathology" @default.
• W2124865173 cites W1517993402 @default.
• W2124865173 cites W1519232679 @default.
• W2124865173 cites W1530102561 @default.
• W2124865173 cites W1627229807 @default.
• W2124865173 cites W1781747365 @default.
• W2124865173 cites W1785869462 @default.
• W2124865173 cites W1838211711 @default.
• W2124865173 cites W1935851919 @default.
• W2124865173 cites W1954301870 @default.
• W2124865173 cites W1959892192 @default.
• W2124865173 cites W1973729800 @default.
• W2124865173 cites W1977235352 @default.
• W2124865173 cites W1978481513 @default.
• W2124865173 cites W1979949814 @default.
• W2124865173 cites W1980656761 @default.
• W2124865173 cites W1981381108 @default.
• W2124865173 cites W1981775108 @default.
• W2124865173 cites W1983298714 @default.
• W2124865173 cites W1986626713 @default.
• W2124865173 cites W1989621915 @default.
• W2124865173 cites W1992490720 @default.
• W2124865173 cites W1994915333 @default.
• W2124865173 cites W1997518026 @default.
• W2124865173 cites W1999506197 @default.
• W2124865173 cites W2011196346 @default.
• W2124865173 cites W2013655437 @default.
• W2124865173 cites W2015251580 @default.
• W2124865173 cites W2015993052 @default.
• W2124865173 cites W2017608248 @default.
• W2124865173 cites W2021318456 @default.
• W2124865173 cites W2024348439 @default.
• W2124865173 cites W2026972964 @default.
• W2124865173 cites W2027740042 @default.
• W2124865173 cites W2028121897 @default.
• W2124865173 cites W2030721900 @default.
• W2124865173 cites W2031462960 @default.
• W2124865173 cites W2035053157 @default.
• W2124865173 cites W2036331664 @default.
• W2124865173 cites W2037894906 @default.
• W2124865173 cites W2038474614 @default.
• W2124865173 cites W2038963210 @default.
• W2124865173 cites W2040700968 @default.
• W2124865173 cites W2041511326 @default.
• W2124865173 cites W2041731336 @default.
• W2124865173 cites W2042040860 @default.
• W2124865173 cites W2043862042 @default.
• W2124865173 cites W2043875236 @default.
• W2124865173 cites W2046134526 @default.
• W2124865173 cites W2049088920 @default.
• W2124865173 cites W2050980301 @default.
• W2124865173 cites W2054088581 @default.
• W2124865173 cites W2068401192 @default.
• W2124865173 cites W2069191317 @default.
• W2124865173 cites W2071576115 @default.
• W2124865173 cites W2072154498 @default.
• W2124865173 cites W2073030636 @default.
• W2124865173 cites W2074082111 @default.
• W2124865173 cites W2074305556 @default.
• W2124865173 cites W2093069882 @default.
• W2124865173 cites W2093954030 @default.
• W2124865173 cites W2101225104 @default.
• W2124865173 cites W2102884007 @default.
• W2124865173 cites W2103398040 @default.
• W2124865173 cites W2110175860 @default.
• W2124865173 cites W2115861749 @default.
• W2124865173 cites W2115902692 @default.
• W2124865173 cites W2117480181 @default.
• W2124865173 cites W2121147520 @default.
• W2124865173 cites W2123013832 @default.
• W2124865173 cites W2133939519 @default.
• W2124865173 cites W2143557510 @default.
• W2124865173 cites W2143609607 @default.
• W2124865173 cites W2152211310 @default.
• W2124865173 cites W2153671031 @default.
• W2124865173 cites W2157085351 @default.
• W2124865173 cites W2158046822 @default.
• W2124865173 cites W2159953069 @default.
• W2124865173 cites W2163094253 @default.
• W2124865173 cites W2164357952 @default.
• W2124865173 cites W2164379597 @default.
• W2124865173 cites W2164717381 @default.
• W2124865173 cites W2168227200 @default.
• W2124865173 cites W2169378022 @default.
• W2124865173 cites W2182516915 @default.
• W2124865173 cites W2182566969 @default.
• W2124865173 cites W2211618869 @default.
• W2124865173 cites W2273601764 @default.
• W2124865173 cites W2404555605 @default.
• W2124865173 cites W26111232 @default.
• W2124865173 cites W4249861700 @default.
• W2124865173 doi "https://doi.org/10.1146/annurev.psych.55.090902.141545" @default.
• W2124865173 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14744212" @default.

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