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• W2124901115 endingPage "8890" @default.
• W2124901115 startingPage "8866" @default.
• W2124901115 abstract "Humans and animals take actions quickly when they expect that the actions lead to reward, reflecting their motivation. Injection of dopamine receptor antagonists into the striatum has been shown to slow such reward-seeking behavior, suggesting that dopamine is involved in the control of motivational processes. Meanwhile, neurophysiological studies have revealed that phasic response of dopamine neurons appears to represent reward prediction error, indicating that dopamine plays central roles in reinforcement learning. However, previous attempts to elucidate the mechanisms of these dopaminergic controls have not fully explained how the motivational and learning aspects are related and whether they can be understood by the way the activity of dopamine neurons itself is controlled by their upstream circuitries. To address this issue, we constructed a closed-circuit model of the corticobasal ganglia system based on recent findings regarding intracortical and corticostriatal circuit architectures. Simulations show that the model could reproduce the observed distinct motivational effects of D 1 - and D 2 -type dopamine receptor antagonists. Simultaneously, our model successfully explains the dopaminergic representation of reward prediction error as observed in behaving animals during learning tasks and could also explain distinct choice biases induced by optogenetic stimulation of the D 1 and D 2 receptor-expressing striatal neurons. These results indicate that the suggested roles of dopamine in motivational control and reinforcement learning can be understood in a unified manner through a notion that the indirect pathway of the basal ganglia represents the value of states/actions at a previous time point, an empirically driven key assumption of our model." @default.
• W2124901115 created "2016-06-24" @default.
• W2124901115 creator A5004827664 @default.
• W2124901115 creator A5041271181 @default.
• W2124901115 creator A5059387763 @default.
• W2124901115 creator A5080141633 @default.
• W2124901115 date "2013-05-15" @default.
• W2124901115 modified "2023-10-16" @default.
• W2124901115 title "Dopaminergic Control of Motivation and Reinforcement Learning: A Closed-Circuit Account for Reward-Oriented Behavior" @default.
• W2124901115 cites W1562703792 @default.
• W2124901115 cites W159677714 @default.
• W2124901115 cites W1652173018 @default.
• W2124901115 cites W1833848025 @default.
• W2124901115 cites W1963750875 @default.
• W2124901115 cites W1964196268 @default.
• W2124901115 cites W1966725992 @default.
• W2124901115 cites W1969392675 @default.
• W2124901115 cites W1970761553 @default.
• W2124901115 cites W1971999279 @default.
• W2124901115 cites W1973074412 @default.
• W2124901115 cites W1974931223 @default.
• W2124901115 cites W1976064429 @default.
• W2124901115 cites W1976284302 @default.
• W2124901115 cites W1978506717 @default.
• W2124901115 cites W1979215131 @default.
• W2124901115 cites W1982827121 @default.
• W2124901115 cites W1983445937 @default.
• W2124901115 cites W1984725541 @default.
• W2124901115 cites W1988220777 @default.
• W2124901115 cites W1991762922 @default.
• W2124901115 cites W1993049331 @default.
• W2124901115 cites W1993631201 @default.
• W2124901115 cites W1995007954 @default.
• W2124901115 cites W1996695526 @default.
• W2124901115 cites W1997128521 @default.
• W2124901115 cites W1999497568 @default.
• W2124901115 cites W2002343527 @default.
• W2124901115 cites W2003565109 @default.
• W2124901115 cites W2005242503 @default.
• W2124901115 cites W2006874412 @default.
• W2124901115 cites W2009299837 @default.
• W2124901115 cites W2010485061 @default.
• W2124901115 cites W2010797301 @default.
• W2124901115 cites W2013314169 @default.
• W2124901115 cites W2019078397 @default.
• W2124901115 cites W2021454300 @default.
• W2124901115 cites W2022561563 @default.
• W2124901115 cites W2022633426 @default.
• W2124901115 cites W2024455301 @default.
• W2124901115 cites W2026640911 @default.
• W2124901115 cites W2031326058 @default.
• W2124901115 cites W2032610016 @default.
• W2124901115 cites W2035774707 @default.
• W2124901115 cites W2036404914 @default.
• W2124901115 cites W2037086157 @default.
• W2124901115 cites W2037197807 @default.
• W2124901115 cites W2040418090 @default.
• W2124901115 cites W2040749203 @default.
• W2124901115 cites W2040943946 @default.
• W2124901115 cites W2043615441 @default.
• W2124901115 cites W2045688922 @default.
• W2124901115 cites W2047598284 @default.
• W2124901115 cites W2049770398 @default.
• W2124901115 cites W2050077524 @default.
• W2124901115 cites W2050233777 @default.
• W2124901115 cites W2051235651 @default.
• W2124901115 cites W2052788949 @default.
• W2124901115 cites W2053269045 @default.
• W2124901115 cites W2054958816 @default.
• W2124901115 cites W2055523610 @default.
• W2124901115 cites W2057613746 @default.
• W2124901115 cites W2058349042 @default.
• W2124901115 cites W2058955351 @default.
• W2124901115 cites W2060588252 @default.
• W2124901115 cites W2060931989 @default.
• W2124901115 cites W2069058023 @default.
• W2124901115 cites W2069618777 @default.
• W2124901115 cites W2075879408 @default.
• W2124901115 cites W2075994330 @default.
• W2124901115 cites W2076256116 @default.
• W2124901115 cites W2076457657 @default.
• W2124901115 cites W2079150537 @default.
• W2124901115 cites W2080093387 @default.
• W2124901115 cites W2083338953 @default.
• W2124901115 cites W2085520758 @default.
• W2124901115 cites W2090763917 @default.
• W2124901115 cites W2093398004 @default.
• W2124901115 cites W2094654753 @default.
• W2124901115 cites W2100752967 @default.
• W2124901115 cites W2100983013 @default.
• W2124901115 cites W2101653246 @default.
• W2124901115 cites W2110016065 @default.
• W2124901115 cites W2114207481 @default.
• W2124901115 cites W2114524506 @default.
• W2124901115 cites W2117726420 @default.
• W2124901115 cites W2118596861 @default.
• W2124901115 cites W2118830830 @default.
• W2124901115 cites W2119170562 @default.

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