Matches in SemOpenAlex for { <https://semopenalex.org/work/W2124911239> ?p ?o ?g. }
Showing items 1 to 88 of
88
with 100 items per page.
- W2124911239 endingPage "244" @default.
- W2124911239 startingPage "235" @default.
- W2124911239 abstract "The no-observed-adverse-effect level (NOAEL) is a dose value that U.S. EPA reduces by uncertainty factors (UF) and modifying factors (MF) to obtain a reference dose (RfD) for input to regulatory decision making. Whether the true added risk at the NOAEL is below an acceptable level, however, is a source of statistical uncertainty itself. As several authors have previously noted, the probability that added risk at the NOAEL is not negligibly small increases as sample sizes decrease. This is because the definition of the NOAEL statistically controls for the chance of a false-positive error, but not for a false-negative error. The false-positive rate is the test level set by the user in testing for a statistically significant dose effect, typically 0.05. When it is held fixed, the increase in statistical uncertainty as sample size decreases produces an increase in the false-negative rate. Hence, the fewer data available for statistical inference, the higher the expected value of the NOAEL and the less toxic an agent is likely to appear. The solution lies in calculating the probability that a statistical procedure used will detect the maximum added risk acceptable for health regulation (the “power” at that added risk). If the observed response in a dose group is not significantly elevated relative to the control group, and the power for detecting a difference is low as well, then the statistical evidence is inconclusive. In such a case, additional data or other sources of information are needed for evaluating added risk. These concepts are illustrated for examples from the literature with dichotomous (quantal response) data and categorical (severity) data, using a new statistical procedure." @default.
- W2124911239 created "2016-06-24" @default.
- W2124911239 creator A5002921160 @default.
- W2124911239 creator A5061471413 @default.
- W2124911239 date "1989-08-01" @default.
- W2124911239 modified "2023-09-24" @default.
- W2124911239 title "Statistical uncertainty in the no-observed-adverse-effect level*1" @default.
- W2124911239 cites W2051236598 @default.
- W2124911239 cites W2080119796 @default.
- W2124911239 cites W2088298837 @default.
- W2124911239 cites W2092132313 @default.
- W2124911239 cites W2169632325 @default.
- W2124911239 cites W2260938729 @default.
- W2124911239 cites W2330813625 @default.
- W2124911239 cites W2905192147 @default.
- W2124911239 doi "https://doi.org/10.1016/0272-0590(89)90260-1" @default.
- W2124911239 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2792592" @default.
- W2124911239 hasPublicationYear "1989" @default.
- W2124911239 type Work @default.
- W2124911239 sameAs 2124911239 @default.
- W2124911239 citedByCount "24" @default.
- W2124911239 countsByYear W21249112392014 @default.
- W2124911239 countsByYear W21249112392015 @default.
- W2124911239 countsByYear W21249112392020 @default.
- W2124911239 countsByYear W21249112392022 @default.
- W2124911239 crossrefType "journal-article" @default.
- W2124911239 hasAuthorship W2124911239A5002921160 @default.
- W2124911239 hasAuthorship W2124911239A5061471413 @default.
- W2124911239 hasConcept C105795698 @default.
- W2124911239 hasConcept C12174686 @default.
- W2124911239 hasConcept C126322002 @default.
- W2124911239 hasConcept C129848803 @default.
- W2124911239 hasConcept C134261354 @default.
- W2124911239 hasConcept C147583825 @default.
- W2124911239 hasConcept C149782125 @default.
- W2124911239 hasConcept C154945302 @default.
- W2124911239 hasConcept C2776214188 @default.
- W2124911239 hasConcept C2777495288 @default.
- W2124911239 hasConcept C33070731 @default.
- W2124911239 hasConcept C33923547 @default.
- W2124911239 hasConcept C38652104 @default.
- W2124911239 hasConcept C41008148 @default.
- W2124911239 hasConcept C65409693 @default.
- W2124911239 hasConcept C71924100 @default.
- W2124911239 hasConcept C86803240 @default.
- W2124911239 hasConcept C87007009 @default.
- W2124911239 hasConcept C96608239 @default.
- W2124911239 hasConceptScore W2124911239C105795698 @default.
- W2124911239 hasConceptScore W2124911239C12174686 @default.
- W2124911239 hasConceptScore W2124911239C126322002 @default.
- W2124911239 hasConceptScore W2124911239C129848803 @default.
- W2124911239 hasConceptScore W2124911239C134261354 @default.
- W2124911239 hasConceptScore W2124911239C147583825 @default.
- W2124911239 hasConceptScore W2124911239C149782125 @default.
- W2124911239 hasConceptScore W2124911239C154945302 @default.
- W2124911239 hasConceptScore W2124911239C2776214188 @default.
- W2124911239 hasConceptScore W2124911239C2777495288 @default.
- W2124911239 hasConceptScore W2124911239C33070731 @default.
- W2124911239 hasConceptScore W2124911239C33923547 @default.
- W2124911239 hasConceptScore W2124911239C38652104 @default.
- W2124911239 hasConceptScore W2124911239C41008148 @default.
- W2124911239 hasConceptScore W2124911239C65409693 @default.
- W2124911239 hasConceptScore W2124911239C71924100 @default.
- W2124911239 hasConceptScore W2124911239C86803240 @default.
- W2124911239 hasConceptScore W2124911239C87007009 @default.
- W2124911239 hasConceptScore W2124911239C96608239 @default.
- W2124911239 hasIssue "2" @default.
- W2124911239 hasLocation W21249112391 @default.
- W2124911239 hasLocation W21249112392 @default.
- W2124911239 hasOpenAccess W2124911239 @default.
- W2124911239 hasPrimaryLocation W21249112391 @default.
- W2124911239 hasRelatedWork W1539998288 @default.
- W2124911239 hasRelatedWork W2035183717 @default.
- W2124911239 hasRelatedWork W2036600297 @default.
- W2124911239 hasRelatedWork W2380849986 @default.
- W2124911239 hasRelatedWork W2753031227 @default.
- W2124911239 hasRelatedWork W2952843659 @default.
- W2124911239 hasRelatedWork W2971029929 @default.
- W2124911239 hasRelatedWork W4211149209 @default.
- W2124911239 hasRelatedWork W4295905522 @default.
- W2124911239 hasRelatedWork W4382599617 @default.
- W2124911239 hasVolume "13" @default.
- W2124911239 isParatext "false" @default.
- W2124911239 isRetracted "false" @default.
- W2124911239 magId "2124911239" @default.
- W2124911239 workType "article" @default.