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• W2124932841 endingPage "3588" @default.
• W2124932841 startingPage "3581" @default.
• W2124932841 abstract "Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. T cell proliferation and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for Thy-1 in mouse T lymphocyte activation. However, a physiological ligand or counterreceptor for murine Thy-1 in the lymphoid compartment has not yet been identified. Thy-1 cross-linking, in the context of strong costimulatory signaling through CD28, results in an activating signal that can at least partially substitute for TCR signaling during mouse T cell activation. Remarkably, Thy-1 cross-linking also results in the potent costimulation of T cells activated through the TCR. This novel dual signaling capacity suggests a possible role for Thy-1 in the maintenance of T cell homeostasis in the absence of TCR triggering, as well as potentiating Ag-induced T cell responses." @default.
• W2124932841 created "2016-06-24" @default.
• W2124932841 creator A5054931979 @default.
• W2124932841 creator A5091763424 @default.
• W2124932841 date "2004-09-07" @default.
• W2124932841 modified "2023-10-13" @default.
• W2124932841 title "Thy-1: More than a Mouse Pan-T Cell Marker" @default.
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• W2124932841 doi "https://doi.org/10.4049/jimmunol.173.6.3581" @default.
• W2124932841 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15356100" @default.
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