Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125005845> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2125005845 endingPage "763" @default.
- W2125005845 startingPage "760" @default.
- W2125005845 abstract "Abstract. Standard texts describe human autosomal recessive polycystic kidney disease (ARPKD) as a cystic kidney disease in which lesions are localized to collecting tubules. Murine models of ARPKD consistently demonstrate an early phase of proximal tubular (PT) cystic involvement, which disappears shortly after birth. This is followed by a phase of collecting tubular (CT) cyst formation and progressive enlargement leading to compromise of renal function and death. Because the description of cystic lesions in human ARPKD has been largely based on postnatal specimens, PT cyst formation was hypothesized to be a characteristic feature of fetal human, as well as murine, ARPKD. This study examines nephron segment-specific cyst localization histochemically by lectin binding in 11 human ARPKD specimens obtained at different fetal and postnatal ages. PT cysts were found in human fetal specimens from gestational age 14 wk to 26 wk. The percentage of cysts involving PT segments ranged from 2 to 41%. The cystic index of PT cysts ranged from 2 to 5. In all specimens in which PT cysts were found, both the percentage of CT cysts and their cystic index were equal to or greater than the percentage of PT cysts and the associated PT cystic index. PT cysts were absent in all kidney specimens older than 34 wk gestational age. It is concluded that human ARPKD, like murine ARPKD, has a transient phase of PT cyst formation during early fetal development." @default.
- W2125005845 created "2016-06-24" @default.
- W2125005845 creator A5014106777 @default.
- W2125005845 creator A5033754308 @default.
- W2125005845 creator A5072484694 @default.
- W2125005845 creator A5083533690 @default.
- W2125005845 creator A5087612486 @default.
- W2125005845 date "2000-04-01" @default.
- W2125005845 modified "2023-10-13" @default.
- W2125005845 title "Proximal Tubular Cysts in Fetal Human Autosomal Recessive Polycystic Kidney Disease" @default.
- W2125005845 cites W1990997051 @default.
- W2125005845 cites W2004441307 @default.
- W2125005845 cites W2019869046 @default.
- W2125005845 cites W2047420152 @default.
- W2125005845 cites W2058678335 @default.
- W2125005845 cites W2066216761 @default.
- W2125005845 cites W2067444609 @default.
- W2125005845 cites W2075895700 @default.
- W2125005845 cites W2776216188 @default.
- W2125005845 doi "https://doi.org/10.1681/asn.v114760" @default.
- W2125005845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10752536" @default.
- W2125005845 hasPublicationYear "2000" @default.
- W2125005845 type Work @default.
- W2125005845 sameAs 2125005845 @default.
- W2125005845 citedByCount "63" @default.
- W2125005845 countsByYear W21250058452012 @default.
- W2125005845 countsByYear W21250058452013 @default.
- W2125005845 countsByYear W21250058452014 @default.
- W2125005845 countsByYear W21250058452015 @default.
- W2125005845 countsByYear W21250058452016 @default.
- W2125005845 countsByYear W21250058452017 @default.
- W2125005845 countsByYear W21250058452018 @default.
- W2125005845 countsByYear W21250058452019 @default.
- W2125005845 countsByYear W21250058452020 @default.
- W2125005845 countsByYear W21250058452021 @default.
- W2125005845 countsByYear W21250058452022 @default.
- W2125005845 countsByYear W21250058452023 @default.
- W2125005845 crossrefType "journal-article" @default.
- W2125005845 hasAuthorship W2125005845A5014106777 @default.
- W2125005845 hasAuthorship W2125005845A5033754308 @default.
- W2125005845 hasAuthorship W2125005845A5072484694 @default.
- W2125005845 hasAuthorship W2125005845A5083533690 @default.
- W2125005845 hasAuthorship W2125005845A5087612486 @default.
- W2125005845 hasBestOaLocation W21250058451 @default.
- W2125005845 hasConcept C126322002 @default.
- W2125005845 hasConcept C142724271 @default.
- W2125005845 hasConcept C172680121 @default.
- W2125005845 hasConcept C2776266639 @default.
- W2125005845 hasConcept C2778376644 @default.
- W2125005845 hasConcept C2779134260 @default.
- W2125005845 hasConcept C2779234561 @default.
- W2125005845 hasConcept C2780091579 @default.
- W2125005845 hasConcept C2780145431 @default.
- W2125005845 hasConcept C2780597408 @default.
- W2125005845 hasConcept C2781231759 @default.
- W2125005845 hasConcept C2910547607 @default.
- W2125005845 hasConcept C54355233 @default.
- W2125005845 hasConcept C71924100 @default.
- W2125005845 hasConcept C86803240 @default.
- W2125005845 hasConceptScore W2125005845C126322002 @default.
- W2125005845 hasConceptScore W2125005845C142724271 @default.
- W2125005845 hasConceptScore W2125005845C172680121 @default.
- W2125005845 hasConceptScore W2125005845C2776266639 @default.
- W2125005845 hasConceptScore W2125005845C2778376644 @default.
- W2125005845 hasConceptScore W2125005845C2779134260 @default.
- W2125005845 hasConceptScore W2125005845C2779234561 @default.
- W2125005845 hasConceptScore W2125005845C2780091579 @default.
- W2125005845 hasConceptScore W2125005845C2780145431 @default.
- W2125005845 hasConceptScore W2125005845C2780597408 @default.
- W2125005845 hasConceptScore W2125005845C2781231759 @default.
- W2125005845 hasConceptScore W2125005845C2910547607 @default.
- W2125005845 hasConceptScore W2125005845C54355233 @default.
- W2125005845 hasConceptScore W2125005845C71924100 @default.
- W2125005845 hasConceptScore W2125005845C86803240 @default.
- W2125005845 hasIssue "4" @default.
- W2125005845 hasLocation W21250058451 @default.
- W2125005845 hasOpenAccess W2125005845 @default.
- W2125005845 hasPrimaryLocation W21250058451 @default.
- W2125005845 hasRelatedWork W2021594260 @default.
- W2125005845 hasRelatedWork W2058383750 @default.
- W2125005845 hasRelatedWork W2110452525 @default.
- W2125005845 hasRelatedWork W2361280987 @default.
- W2125005845 hasRelatedWork W2492303229 @default.
- W2125005845 hasRelatedWork W2736703409 @default.
- W2125005845 hasRelatedWork W2906737259 @default.
- W2125005845 hasRelatedWork W3124579384 @default.
- W2125005845 hasRelatedWork W3172311957 @default.
- W2125005845 hasRelatedWork W4308198142 @default.
- W2125005845 hasVolume "11" @default.
- W2125005845 isParatext "false" @default.
- W2125005845 isRetracted "false" @default.
- W2125005845 magId "2125005845" @default.
- W2125005845 workType "article" @default.