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• W2125014145 abstract "The immune response of adult BALB/c mice against the bacterial antigen dextran B13558 (Dex) is well characterized as thymus independent (TI type 2) and Igha linked. The antisera consist of mainly IgM/ antibodies directed against the λ(1 → 3) glucosidic linkage. This study describes the immune reponse against the α(1 → 3) linkage in the thymus dependent form (TD), i. e. tetra- or heptasaccharides (N4 or N7) of glucose as hapten coupled to chicken serum albumin (CSA) as carrier. Whereas athymic BALB/c-nu/nu mice did not respond to the TD antigens N4-CSA and N7-CSA, euthymic BALB/c showed high anti-Dex antibody titres of IgM and, after 2° immunization, a class switch to IgG (mainly IgGl) isotypes with λ light chains. The hapten N4 inhibited Dex-binding of M104E or of antisera from Dex or N4-CSA or N7-CSA immunized mice at 1.7–10 × 104M. The idiotype composition of these antibodies resembled those after Dex immunization. We conclude that the same Dex-specific precursor B cells have been stimulated by either form of antigen. The ontogenic development of a Dex-specific response could not be accelerated by the aid of T cells, even of adult origin. It seems, therefore, that the maturation of antigen specific B cells is the limiting step in ontogeny." @default.
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• W2125014145 date "1995-09-01" @default.
• W2125014145 modified "2023-09-23" @default.
• W2125014145 title "Stimulation of the Same B-Cell Population by Thymus-Independent Dextran and by Thymus-Dependent Oligosaccharide-Carrier" @default.
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• W2125014145 doi "https://doi.org/10.1111/j.1365-3083.1995.tb03666.x" @default.
• W2125014145 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7544910" @default.
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