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- W2125015702 abstract "To date, the authors know of no prospective studies of sustained-release bupropion in depressed HIV-seropositive patients. The purpose of this study was to evaluate the efficacy and tolerability of sustained-release bupropion in 20 depressed HIV-positive adult outpatients. Twenty outpatients with HIV spectrum illness, a DSM-IV-diagnosed major depressive disorder confirmed with the Structured Clinical Interview for DSM-IV, and Mini-Mental State Examination scores >20 were recruited into a 6-week, open-label, flexible-dose study of sustained-release bupropion (100-300 mg/day). Twelve patients (60%) responded to sustained-release bupropion at a mean dose of 265 mg/day. Five patients (25%) discontinued study participation secondary to adverse events. Preliminary findings suggest that sustained-release bupropion is effective for the treatment of depression in HIV-positive patients, regardless of HIV clinical staging. Furthermore, it appears to be well tolerated in patients with AIDS-related medical conditions." @default.
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- W2125015702 date "2003-03-01" @default.
- W2125015702 modified "2023-10-18" @default.
- W2125015702 title "A Prospective Trial of Sustained-Release Bupropion for Depression in HIV-Seropositive and AIDS Patients" @default.
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- W2125015702 doi "https://doi.org/10.1176/appi.psy.44.2.120" @default.
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