FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125016788> ?p ?o ?g. }

• W2125016788 abstract "Neuronal communication is tightly regulated in time and space. Following neuronal activation, an electrical signal triggers neurotransmitter (NT) release at the active zone. The process starts by the signal reaching the synapse followed by a fusion of the synaptic vesicle (SV) and diffusion of the released NT in the synaptic cleft. The NT then binds to the appropriate receptor and induces a membrane potential change at the target cell membrane. The entire process is controlled by a fairly small set of synaptic proteins, collectively called SYCONs. The biochemical features of SYCONs underlie the properties of NT release. SYCONs are characterized by their ability to detect and respond to changes in environmental signals. For example, consider synaptotagmin I (Syt1), a prototype of a protein family with over 20 gene and variants in mammals. Syt1 is a specific example of a multi-sensor device with a large repertoire of discrete states. Several of these states are stimulated by a local concentration of signaling molecules such as Ca2+. The ability of this protein to sense signaling molecules and to adopt multiple biochemical states is shared by other SYCONs such as the synapsins (Syns). Specific biochemical states of Syns determine the accessibility of SV for NT release. Each of these states is defined by a specific alternative spliced variant with a unique profile of phosphorylation modified sites. The plasticity of the synapse is a direct reflection of SYCON's multiple biochemical states. State transitions occurs in a wide range of time scales, and therefore these molecules need to cope with events that last milliseconds (i.e., exocytosis in fast responding synapses) and with events that can carry on for many minutes (i.e., organization of SV pools). We suggest that SYCONs are optimized throughout evolution as multi-sensor devices. A full repertoire of the switches leading to alternation of protein states and a detailed characterization of protein-protein network within the synapse is critical for the development of a dynamic model of synaptic transmission." @default.
• W2125016788 created "2016-06-24" @default.
• W2125016788 creator A5005518309 @default.
• W2125016788 creator A5040860058 @default.
• W2125016788 creator A5085924022 @default.
• W2125016788 date "2006-10-01" @default.
• W2125016788 modified "2023-09-27" @default.
• W2125016788 title "Synaptic proteins as multi-sensor devices of neurotransmission" @default.
• W2125016788 cites W1589189210 @default.
• W2125016788 cites W1679417272 @default.
• W2125016788 cites W184718354 @default.
• W2125016788 cites W1964597228 @default.
• W2125016788 cites W1966229750 @default.
• W2125016788 cites W1966363007 @default.
• W2125016788 cites W1969288514 @default.
• W2125016788 cites W1970959054 @default.
• W2125016788 cites W1974052675 @default.
• W2125016788 cites W1975086853 @default.
• W2125016788 cites W1975364281 @default.
• W2125016788 cites W1977237222 @default.
• W2125016788 cites W1979142848 @default.
• W2125016788 cites W1982085211 @default.
• W2125016788 cites W1985512071 @default.
• W2125016788 cites W1992638924 @default.
• W2125016788 cites W1996216646 @default.
• W2125016788 cites W1997606826 @default.
• W2125016788 cites W2004162932 @default.
• W2125016788 cites W2008146383 @default.
• W2125016788 cites W2008771792 @default.
• W2125016788 cites W2010313687 @default.
• W2125016788 cites W2012627635 @default.
• W2125016788 cites W2019378194 @default.
• W2125016788 cites W2020685542 @default.
• W2125016788 cites W2030987020 @default.
• W2125016788 cites W2033797809 @default.
• W2125016788 cites W2035232906 @default.
• W2125016788 cites W2041199542 @default.
• W2125016788 cites W2042447398 @default.
• W2125016788 cites W2044162798 @default.
• W2125016788 cites W2047627768 @default.
• W2125016788 cites W2049511526 @default.
• W2125016788 cites W2051025707 @default.
• W2125016788 cites W2054473035 @default.
• W2125016788 cites W2061260576 @default.
• W2125016788 cites W2061742917 @default.
• W2125016788 cites W2063779755 @default.
• W2125016788 cites W2066194382 @default.
• W2125016788 cites W2072167784 @default.
• W2125016788 cites W2074969527 @default.
• W2125016788 cites W2076386790 @default.
• W2125016788 cites W2082086201 @default.
• W2125016788 cites W2085825273 @default.
• W2125016788 cites W2093403258 @default.
• W2125016788 cites W2095553049 @default.
• W2125016788 cites W2102875752 @default.
• W2125016788 cites W2108632260 @default.
• W2125016788 cites W2116129077 @default.
• W2125016788 cites W2125343900 @default.
• W2125016788 cites W2139055855 @default.
• W2125016788 cites W2151327803 @default.
• W2125016788 cites W2153763976 @default.
• W2125016788 cites W2154100802 @default.
• W2125016788 cites W2165302477 @default.
• W2125016788 cites W2168783124 @default.
• W2125016788 cites W2179142127 @default.
• W2125016788 cites W4233126096 @default.
• W2125016788 cites W4248649089 @default.
• W2125016788 cites W4361865000 @default.
• W2125016788 doi "https://doi.org/10.1186/1471-2202-7-s1-s4" @default.
• W2125016788 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1775044" @default.
• W2125016788 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17118158" @default.
• W2125016788 hasPublicationYear "2006" @default.
• W2125016788 type Work @default.
• W2125016788 sameAs 2125016788 @default.
• W2125016788 citedByCount "9" @default.
• W2125016788 countsByYear W21250167882016 @default.
• W2125016788 countsByYear W21250167882019 @default.
• W2125016788 countsByYear W21250167882022 @default.
• W2125016788 crossrefType "journal-article" @default.
• W2125016788 hasAuthorship W2125016788A5005518309 @default.
• W2125016788 hasAuthorship W2125016788A5040860058 @default.
• W2125016788 hasAuthorship W2125016788A5085924022 @default.
• W2125016788 hasBestOaLocation W21250167881 @default.
• W2125016788 hasConcept C127445978 @default.
• W2125016788 hasConcept C130316041 @default.
• W2125016788 hasConcept C146759223 @default.
• W2125016788 hasConcept C148785051 @default.
• W2125016788 hasConcept C169760540 @default.
• W2125016788 hasConcept C170493617 @default.
• W2125016788 hasConcept C182469116 @default.
• W2125016788 hasConcept C196330066 @default.
• W2125016788 hasConcept C200170125 @default.
• W2125016788 hasConcept C26987225 @default.
• W2125016788 hasConcept C2776219046 @default.
• W2125016788 hasConcept C2909695770 @default.
• W2125016788 hasConcept C41625074 @default.
• W2125016788 hasConcept C529278444 @default.
• W2125016788 hasConcept C55493867 @default.
• W2125016788 hasConcept C74373430 @default.
• W2125016788 hasConcept C86473631 @default.

• next