Matches in SemOpenAlex for { <https://semopenalex.org/work/W212504421> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W212504421 endingPage "185" @default.
- W212504421 startingPage "177" @default.
- W212504421 abstract "We have investigated the mouse mammary tumor virus (MMTV) specific proviral DNA content of the C57BL and GR strains of mice by restriction endonuclease digestion of cellular DNA and Southern transfer of DNA fragments to nitrocellulose filter paper. GR mice develop 100% mammary tumors at an early age whereas C57BL mice have less than a one percent incidence. The MMTV containing DNA fragments were identified by hybridization to MMTV [32P] complementary DNA. Digestion of cellular DNA with the restriction endonuclease Pst-1, which generates multiple internal MMTV specific DNA fragments, has identified viral DNA fragments at 2.5 and 0.6 megadaltons in the GR DNA, which are absent in the C57BL DNA. The GR and C57BL mice share Pst-1 restriction fragments at 3.3, 1.1, 0.9 and 0.5 megadaltons. The C57BL mouse has a Pst-1 restriction fragment at 3.1 megadaltons which is absent in DNA from GR mice. Genetic analyses of GR and C57BL crosses has determined that the Pst-1 fragments specific for the GR MMTV are inherited as a single Mendelian unit in [C57BL × (C57BL × GR)F1] backcross mice, i.e., 50 percent of the livers examined contain Pst-1 fragments at 2.5 and 0.6 megadaltons. We have been able to correlate the presence of these MMTV(GR) specific Pst-1 fragments with the occurrence of early mammary tumors in the [C57BL × (C57BL × GR)F1] backcross mice. These studies thus demonstrate the utility of restriction mapping in the diagnosis of a naturally occurring neoplasm." @default.
- W212504421 created "2016-06-24" @default.
- W212504421 creator A5024216593 @default.
- W212504421 creator A5058847171 @default.
- W212504421 creator A5059931764 @default.
- W212504421 date "1980-01-01" @default.
- W212504421 modified "2023-09-27" @default.
- W212504421 title "CORRELATION BETWEEN THE DEVELOPMENT OF MURINE MAMMARY CANCER AND THE SEGREGATION OF ENDOGENOUS GENES" @default.
- W212504421 cites W1486906704 @default.
- W212504421 cites W1559145851 @default.
- W212504421 cites W2036318864 @default.
- W212504421 cites W2038124483 @default.
- W212504421 cites W2054530096 @default.
- W212504421 cites W2102699980 @default.
- W212504421 cites W2129317689 @default.
- W212504421 doi "https://doi.org/10.1016/b978-0-12-255850-4.50020-2" @default.
- W212504421 hasPublicationYear "1980" @default.
- W212504421 type Work @default.
- W212504421 sameAs 212504421 @default.
- W212504421 citedByCount "0" @default.
- W212504421 crossrefType "book-chapter" @default.
- W212504421 hasAuthorship W212504421A5024216593 @default.
- W212504421 hasAuthorship W212504421A5058847171 @default.
- W212504421 hasAuthorship W212504421A5059931764 @default.
- W212504421 hasConcept C121608353 @default.
- W212504421 hasConcept C128319531 @default.
- W212504421 hasConcept C153911025 @default.
- W212504421 hasConcept C2776187077 @default.
- W212504421 hasConcept C2779777497 @default.
- W212504421 hasConcept C530470458 @default.
- W212504421 hasConcept C54355233 @default.
- W212504421 hasConcept C552990157 @default.
- W212504421 hasConcept C84289048 @default.
- W212504421 hasConcept C86803240 @default.
- W212504421 hasConceptScore W212504421C121608353 @default.
- W212504421 hasConceptScore W212504421C128319531 @default.
- W212504421 hasConceptScore W212504421C153911025 @default.
- W212504421 hasConceptScore W212504421C2776187077 @default.
- W212504421 hasConceptScore W212504421C2779777497 @default.
- W212504421 hasConceptScore W212504421C530470458 @default.
- W212504421 hasConceptScore W212504421C54355233 @default.
- W212504421 hasConceptScore W212504421C552990157 @default.
- W212504421 hasConceptScore W212504421C84289048 @default.
- W212504421 hasConceptScore W212504421C86803240 @default.
- W212504421 hasLocation W2125044211 @default.
- W212504421 hasOpenAccess W212504421 @default.
- W212504421 hasPrimaryLocation W2125044211 @default.
- W212504421 hasRelatedWork W1565148302 @default.
- W212504421 hasRelatedWork W1806648924 @default.
- W212504421 hasRelatedWork W1982917919 @default.
- W212504421 hasRelatedWork W1992813005 @default.
- W212504421 hasRelatedWork W2000938414 @default.
- W212504421 hasRelatedWork W212504421 @default.
- W212504421 hasRelatedWork W2145368198 @default.
- W212504421 hasRelatedWork W2168813486 @default.
- W212504421 hasRelatedWork W2169756550 @default.
- W212504421 hasRelatedWork W2486061802 @default.
- W212504421 isParatext "false" @default.
- W212504421 isRetracted "false" @default.
- W212504421 magId "212504421" @default.
- W212504421 workType "book-chapter" @default.