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- W2125067283 abstract "The in vitro disintegration behavior of fast dissolving systems manufactured by the main commercialized technologies was studied using the texture analyzer (TA) instrument. Quantitative parameters were employed to characterize the effect of the major test variables on the disintegration profiles. The average disintegration profiles of the products were compared using the test conditions that minimized these effects and at the same time mimicked the in vivo situation in the patient's mouth. The differences in the disintegration mechanisms of the fast dissolving systems were reflected in the shape of their disintegration profiles and in the parameters derived from the profiles. The differences were explained in relation to the technology and/or formulation characteristics involved in the manufacture of each product. The in vitro disintegration times obtained under the simulated in vivo conditions were correlated with the reported in vivo disintegration times." @default.
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- W2125067283 date "2002-01-01" @default.
- W2125067283 modified "2023-09-30" @default.
- W2125067283 title "Evaluation of Disintegration Testing of Different Fast Dissolving Tablets Using the Texture Analyzer" @default.
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- W2125067283 doi "https://doi.org/10.1081/pdt-120005732" @default.
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