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- W2125073253 abstract "The effect of halothane on intracellular Ca 2+ concentration ([Ca 2+ ] i ) regulation in porcine tracheal smooth muscle cells was examined with real-time confocal microscopy. Both 1 and 2 minimum alveolar concentration (MAC) halothane increased basal [Ca 2+ ] i when Ca 2+ influx and efflux were blocked, suggesting increased sarcoplasmic reticulum (SR) Ca 2+ leak and/or decreased reuptake. In β-escin-permeabilized cells, heparin inhibition of inositol 1,4,5-trisphosphate-receptor channels blunted the halothane-induced increase in [Ca 2+ ] i . Both 1 and 2 MAC halothane decreased the frequency and amplitude of ACh-induced [Ca 2+ ] i oscillations (which represent SR Ca 2+ release through ryanodine-receptor channels), abolishing oscillations in ∼20% of tracheal smooth muscle cells at 2 MAC. When Ca 2+ influx and efflux were blocked, halothane increased the baseline and decreased the frequency and amplitude of [Ca 2+ ] i oscillations, inhibiting oscillations in ∼70% of cells at 2 MAC. The fall time of [Ca 2+ ] i oscillations and the rate of fall of the [Ca 2+ ] i response to caffeine were both increased by halothane. These results suggest that halothane abolishes agonist-induced [Ca 2+ ] i oscillations by 1) depleting SR Ca 2+ via increased Ca 2+ leak through inositol 1,4,5-trisphosphate-receptor channels, 2) decreasing Ca 2+ release through ryanodine-receptor channels, and 3) inhibiting reuptake." @default.
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- W2125073253 date "1999-01-01" @default.
- W2125073253 modified "2023-10-12" @default.
- W2125073253 title "Effect of halothane on intracellular calcium oscillations in porcine tracheal smooth muscle cells" @default.
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- W2125073253 doi "https://doi.org/10.1152/ajplung.1999.276.1.l81" @default.
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