Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125085874> ?p ?o ?g. }
- W2125085874 endingPage "215" @default.
- W2125085874 startingPage "183" @default.
- W2125085874 abstract "The advent of monoclonal antibodies has revitalised the concept of magic bullets and various agents (eg. drugs, toxins and isotopes) have been conjugated to monoclonal antibodies for selective delivery to tumours. Preclinical studies in mouse tumour models have been impressive and have lead to several clinical trials. These phase I trials have been less impressive. However, keeping in mind the aim of Phase I trials, the safety of using these conjugates in humans have been established. Several, major problems still remain to be overcome before these agents may be useful for the treatment of cancer. These problems stem from the nature of tumour vasculature, cytotoxic activity of the moiety linked to antibody and the targeted tumour antigen expressed on the cell surface. This review will deal with these various aspects described above and possible approaches to overcome these obstacles with a definite bias towards drug-monoclonal antibody conjugates. However, these concepts are equally applicable for improved targeting of other agents." @default.
- W2125085874 created "2016-06-24" @default.
- W2125085874 creator A5011443173 @default.
- W2125085874 creator A5028909942 @default.
- W2125085874 date "1994-01-01" @default.
- W2125085874 modified "2023-10-17" @default.
- W2125085874 title "Antibody-Targeted Drugs for the Therapy of Cancer" @default.
- W2125085874 cites W14621223 @default.
- W2125085874 cites W1483963831 @default.
- W2125085874 cites W1529386421 @default.
- W2125085874 cites W1547025320 @default.
- W2125085874 cites W1550930711 @default.
- W2125085874 cites W1555210583 @default.
- W2125085874 cites W1562311277 @default.
- W2125085874 cites W1564925934 @default.
- W2125085874 cites W1576018417 @default.
- W2125085874 cites W1667153140 @default.
- W2125085874 cites W1869022915 @default.
- W2125085874 cites W1909111805 @default.
- W2125085874 cites W1939186328 @default.
- W2125085874 cites W1963639913 @default.
- W2125085874 cites W1966130495 @default.
- W2125085874 cites W1966645689 @default.
- W2125085874 cites W1968015275 @default.
- W2125085874 cites W1969058638 @default.
- W2125085874 cites W1969510504 @default.
- W2125085874 cites W1974035878 @default.
- W2125085874 cites W1976719626 @default.
- W2125085874 cites W1978770120 @default.
- W2125085874 cites W1978795134 @default.
- W2125085874 cites W1979882313 @default.
- W2125085874 cites W1981696952 @default.
- W2125085874 cites W1981908215 @default.
- W2125085874 cites W1989053318 @default.
- W2125085874 cites W1990723065 @default.
- W2125085874 cites W1990732655 @default.
- W2125085874 cites W1990734308 @default.
- W2125085874 cites W1992195074 @default.
- W2125085874 cites W1998084451 @default.
- W2125085874 cites W2003753765 @default.
- W2125085874 cites W2008870308 @default.
- W2125085874 cites W2009867960 @default.
- W2125085874 cites W2015031811 @default.
- W2125085874 cites W2016543214 @default.
- W2125085874 cites W2017681450 @default.
- W2125085874 cites W2017846433 @default.
- W2125085874 cites W2021516369 @default.
- W2125085874 cites W2021636693 @default.
- W2125085874 cites W2023249515 @default.
- W2125085874 cites W2026353314 @default.
- W2125085874 cites W2027565419 @default.
- W2125085874 cites W2029067560 @default.
- W2125085874 cites W2029325023 @default.
- W2125085874 cites W2029510823 @default.
- W2125085874 cites W2030982970 @default.
- W2125085874 cites W2031087372 @default.
- W2125085874 cites W2033050305 @default.
- W2125085874 cites W2035565255 @default.
- W2125085874 cites W2036271174 @default.
- W2125085874 cites W2040505385 @default.
- W2125085874 cites W2043593026 @default.
- W2125085874 cites W2044472571 @default.
- W2125085874 cites W2045951856 @default.
- W2125085874 cites W2046110140 @default.
- W2125085874 cites W2049348498 @default.
- W2125085874 cites W2049822454 @default.
- W2125085874 cites W2050615063 @default.
- W2125085874 cites W2051704704 @default.
- W2125085874 cites W2052150715 @default.
- W2125085874 cites W2054282056 @default.
- W2125085874 cites W2055470738 @default.
- W2125085874 cites W2057978840 @default.
- W2125085874 cites W2060307758 @default.
- W2125085874 cites W2061167242 @default.
- W2125085874 cites W2061530347 @default.
- W2125085874 cites W2061888165 @default.
- W2125085874 cites W2061926775 @default.
- W2125085874 cites W2064620605 @default.
- W2125085874 cites W2066736414 @default.
- W2125085874 cites W2068797099 @default.
- W2125085874 cites W2072695886 @default.
- W2125085874 cites W2074783652 @default.
- W2125085874 cites W2075771579 @default.
- W2125085874 cites W2081543802 @default.
- W2125085874 cites W2082271415 @default.
- W2125085874 cites W2082673847 @default.
- W2125085874 cites W2083726090 @default.
- W2125085874 cites W2085502802 @default.
- W2125085874 cites W2086940701 @default.
- W2125085874 cites W2087947855 @default.
- W2125085874 cites W2092217835 @default.
- W2125085874 cites W2092752384 @default.
- W2125085874 cites W2092938566 @default.
- W2125085874 cites W2093294005 @default.
- W2125085874 cites W2106833014 @default.
- W2125085874 cites W2107155808 @default.
- W2125085874 cites W2111985450 @default.
- W2125085874 cites W2115445134 @default.