FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125087686> ?p ?o ?g. }

• W2125087686 endingPage "G763" @default.
• W2125087686 startingPage "G757" @default.
• W2125087686 abstract "Experimental evidence suggests that glucose modulates gastric functions via vagally mediated effects. It is unclear whether glucose affects only peripheral vagal nerve activity or whether glucose also modulates vagal circuitry at the level of the brain stem. This study used whole cell patch-clamp recordings from neurons of the nucleus of the tractus solitarius (NTS) to assess whether acute variations in glucose modulates vagal brain stem neurocircuitry. Increasing d-glucose concentration induced a postsynaptic response in 40% of neurons; neither the response type (inward vs. outward current) nor response magnitude was altered in the presence of tetrodotoxin suggesting direct effects on the NTS neuronal membrane. In contrast, reducing d-glucose concentration induced a postsynaptic response (inward or outward current) in 54% of NTS neurons; tetrodotoxin abolished these responses, suggesting indirect sites of action. The frequency, but not amplitude, of spontaneous and miniature excitatory postsynaptic currents (EPSCs) was correlated with d-glucose concentration in 79% of neurons tested ( n = 48). Prior surgical afferent rhizotomy abolished the ability of d-glucose to modulate spontaneous EPSC frequency, suggesting presynaptic actions at vagal afferent nerve terminals to modulate glutamatergic synaptic transmission. In experiments in which EPSCs were evoked via electrical stimulation of the tractus solitarius, EPSC amplitude correlated with d-glucose concentration. These effects were not mimicked by l-glucose, suggesting the involvement of glucose metabolism, not uptake, in the nerve terminal. These data suggest that the synaptic connections between vagal afferent nerve terminals and NTS neurons are a strong candidate for consideration as one of the sites where glucose-evoked changes in vagovagal reflexes occurs." @default.
• W2125087686 created "2016-06-24" @default.
• W2125087686 creator A5004701708 @default.
• W2125087686 creator A5026953161 @default.
• W2125087686 date "2008-03-01" @default.
• W2125087686 modified "2023-09-27" @default.
• W2125087686 title "<scp>d</scp>-Glucose modulates synaptic transmission from the central terminals of vagal afferent fibers" @default.
• W2125087686 cites W104554780 @default.
• W2125087686 cites W1577855983 @default.
• W2125087686 cites W1601072169 @default.
• W2125087686 cites W1902151435 @default.
• W2125087686 cites W1968750290 @default.
• W2125087686 cites W1988861579 @default.
• W2125087686 cites W1989092494 @default.
• W2125087686 cites W1989697076 @default.
• W2125087686 cites W1991015425 @default.
• W2125087686 cites W1996269543 @default.
• W2125087686 cites W1999772445 @default.
• W2125087686 cites W2002073684 @default.
• W2125087686 cites W2002698019 @default.
• W2125087686 cites W2004085235 @default.
• W2125087686 cites W2005843560 @default.
• W2125087686 cites W2009623765 @default.
• W2125087686 cites W2012129329 @default.
• W2125087686 cites W2012516129 @default.
• W2125087686 cites W2021897528 @default.
• W2125087686 cites W2024882862 @default.
• W2125087686 cites W2025821901 @default.
• W2125087686 cites W2026533740 @default.
• W2125087686 cites W2034267014 @default.
• W2125087686 cites W2040929224 @default.
• W2125087686 cites W2042642359 @default.
• W2125087686 cites W2049378139 @default.
• W2125087686 cites W2049795844 @default.
• W2125087686 cites W2053718873 @default.
• W2125087686 cites W2054948720 @default.
• W2125087686 cites W2076540171 @default.
• W2125087686 cites W2078990994 @default.
• W2125087686 cites W2082854341 @default.
• W2125087686 cites W2084716996 @default.
• W2125087686 cites W2085771633 @default.
• W2125087686 cites W2091630645 @default.
• W2125087686 cites W2096436906 @default.
• W2125087686 cites W2096823295 @default.
• W2125087686 cites W2099781923 @default.
• W2125087686 cites W2111349683 @default.
• W2125087686 cites W2112927743 @default.
• W2125087686 cites W2112930262 @default.
• W2125087686 cites W2124427153 @default.
• W2125087686 cites W2124737580 @default.
• W2125087686 cites W2125641405 @default.
• W2125087686 cites W2127575529 @default.
• W2125087686 cites W2131361751 @default.
• W2125087686 cites W2133281107 @default.
• W2125087686 cites W2134867426 @default.
• W2125087686 cites W2138969187 @default.
• W2125087686 cites W2145116039 @default.
• W2125087686 cites W2148049649 @default.
• W2125087686 cites W2168767331 @default.
• W2125087686 cites W2180824304 @default.
• W2125087686 cites W2261272110 @default.
• W2125087686 cites W2312729342 @default.
• W2125087686 doi "https://doi.org/10.1152/ajpgi.00576.2007" @default.
• W2125087686 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18202107" @default.
• W2125087686 hasPublicationYear "2008" @default.
• W2125087686 type Work @default.
• W2125087686 sameAs 2125087686 @default.
• W2125087686 citedByCount "34" @default.
• W2125087686 countsByYear W21250876862012 @default.
• W2125087686 countsByYear W21250876862013 @default.
• W2125087686 countsByYear W21250876862014 @default.
• W2125087686 countsByYear W21250876862015 @default.
• W2125087686 countsByYear W21250876862016 @default.
• W2125087686 countsByYear W21250876862017 @default.
• W2125087686 countsByYear W21250876862018 @default.
• W2125087686 countsByYear W21250876862019 @default.
• W2125087686 countsByYear W21250876862020 @default.
• W2125087686 countsByYear W21250876862021 @default.
• W2125087686 countsByYear W21250876862022 @default.
• W2125087686 crossrefType "journal-article" @default.
• W2125087686 hasAuthorship W2125087686A5004701708 @default.
• W2125087686 hasAuthorship W2125087686A5026953161 @default.
• W2125087686 hasConcept C112592302 @default.
• W2125087686 hasConcept C126322002 @default.
• W2125087686 hasConcept C134018914 @default.
• W2125087686 hasConcept C169760540 @default.
• W2125087686 hasConcept C170493617 @default.
• W2125087686 hasConcept C17077164 @default.
• W2125087686 hasConcept C185592680 @default.
• W2125087686 hasConcept C197341189 @default.
• W2125087686 hasConcept C200170125 @default.
• W2125087686 hasConcept C24998067 @default.
• W2125087686 hasConcept C2776741303 @default.
• W2125087686 hasConcept C2779929655 @default.
• W2125087686 hasConcept C2780648746 @default.
• W2125087686 hasConcept C2781404750 @default.
• W2125087686 hasConcept C2910581834 @default.
• W2125087686 hasConcept C55493867 @default.

• next