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- W2125144175 endingPage "1020" @default.
- W2125144175 startingPage "1009" @default.
- W2125144175 abstract "The sphingolipids ceramide and sphingosine 1-phosphate (S1P) are key regulators of cell death and proliferation. The subtle balance between their intracellular levels is governed mainly by sphingosine kinase-1, which produces the pro-survival S1P. Sphingosine kinase-1 is an oncogene; is overexpressed in many tumors; protects cancer cells from apoptosis in vitro and in vivo; and its activity is decreased by anticancer therapies. Hence, sphingosine kinase-1 appears to be a target of interest for therapeutic manipulation.This review considers recent developments regarding the involvement of sphingosine kinase-1 as a therapeutic target for cancer, and describes the pharmacological tools currently available.The studies described provide strong evidence that strategies to kill cancer cells via sphingosine kinase-1 inhibition are valid and could have a favorable therapeutic index." @default.
- W2125144175 created "2016-06-24" @default.
- W2125144175 creator A5009584708 @default.
- W2125144175 date "2008-07-12" @default.
- W2125144175 modified "2023-10-16" @default.
- W2125144175 title "Downregulating sphingosine kinase-1 for cancer therapy" @default.
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