FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125161330> ?p ?o ?g. }

• W2125161330 endingPage "6655" @default.
• W2125161330 startingPage "6642" @default.
• W2125161330 abstract "ABSTRACT The facultative intracellular bacterium Francisella tularensis causes the zoonotic disease tularemia. F. tularensis resides within host macrophages in vivo, and this ability is essential for pathogenesis. The transcription factor MglA is required for the expression of several Francisella genes that are necessary for replication in macrophages and for virulence in mice. We hypothesized that the identification of MglA-regulated genes in the Francisella genome by transcriptional profiling of wild-type and mglA mutant bacteria would lead to the discovery of new virulence factors utilized by F. tularensis . A total of 102 MglA-regulated genes were identified, the majority of which were positively regulated, including all of the Francisella pathogenicity island (FPI) genes. We mutated novel MglA-regulated genes and tested the mutants for their ability to replicate and induce cytotoxicity in macrophages and to grow in mice. Mutations in MglA-regulated genes within the FPI ( pdpB and cds2 ) as well as outside the FPI (FTT0989, oppB , and FTT1209c) were either attenuated or hypervirulent in macrophages compared to the wild-type strain. All of these mutants exhibited decreased fitness in vivo in competition experiments with wild-type bacteria. We have identified five new Francisella virulence genes, and our results suggest that characterizations of additional MglA-regulated genes will yield further insights into the pathogenesis of this bacterium." @default.
• W2125161330 created "2016-06-24" @default.
• W2125161330 creator A5006014190 @default.
• W2125161330 creator A5009161164 @default.
• W2125161330 creator A5029196242 @default.
• W2125161330 creator A5031762888 @default.
• W2125161330 creator A5035054562 @default.
• W2125161330 creator A5051497173 @default.
• W2125161330 creator A5089876195 @default.
• W2125161330 date "2006-12-01" @default.
• W2125161330 modified "2023-10-12" @default.
• W2125161330 title "Identification of MglA-Regulated Genes Reveals Novel Virulence Factors in <i>Francisella tularensis</i>" @default.
• W2125161330 cites W1543001103 @default.
• W2125161330 cites W1549647993 @default.
• W2125161330 cites W1565711667 @default.
• W2125161330 cites W1578104218 @default.
• W2125161330 cites W1601582061 @default.
• W2125161330 cites W1750275338 @default.
• W2125161330 cites W1876472679 @default.
• W2125161330 cites W1968146772 @default.
• W2125161330 cites W1968769252 @default.
• W2125161330 cites W1972010400 @default.
• W2125161330 cites W1983109303 @default.
• W2125161330 cites W1991344758 @default.
• W2125161330 cites W2001740561 @default.
• W2125161330 cites W2012596360 @default.
• W2125161330 cites W2013959608 @default.
• W2125161330 cites W2019594943 @default.
• W2125161330 cites W2022537334 @default.
• W2125161330 cites W2031942563 @default.
• W2125161330 cites W2032870665 @default.
• W2125161330 cites W2047005829 @default.
• W2125161330 cites W2050048558 @default.
• W2125161330 cites W2059258210 @default.
• W2125161330 cites W2062306301 @default.
• W2125161330 cites W2084598611 @default.
• W2125161330 cites W2085304201 @default.
• W2125161330 cites W2091220292 @default.
• W2125161330 cites W2092989878 @default.
• W2125161330 cites W2094823810 @default.
• W2125161330 cites W2095268506 @default.
• W2125161330 cites W2108894780 @default.
• W2125161330 cites W2113333497 @default.
• W2125161330 cites W2123157749 @default.
• W2125161330 cites W2132285289 @default.
• W2125161330 cites W2133253129 @default.
• W2125161330 cites W2133515094 @default.
• W2125161330 cites W2136330456 @default.
• W2125161330 cites W2144701572 @default.
• W2125161330 cites W2147633054 @default.
• W2125161330 cites W2150926065 @default.
• W2125161330 cites W2153416935 @default.
• W2125161330 cites W2157795344 @default.
• W2125161330 cites W2159656294 @default.
• W2125161330 cites W2166802926 @default.
• W2125161330 cites W2167189352 @default.
• W2125161330 cites W2167960824 @default.
• W2125161330 cites W2168630936 @default.
• W2125161330 cites W2170163435 @default.
• W2125161330 cites W2171088586 @default.
• W2125161330 cites W2409802009 @default.
• W2125161330 cites W4211067865 @default.
• W2125161330 cites W4294107304 @default.
• W2125161330 doi "https://doi.org/10.1128/iai.01250-06" @default.
• W2125161330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1698089" @default.
• W2125161330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17000729" @default.
• W2125161330 hasPublicationYear "2006" @default.
• W2125161330 type Work @default.
• W2125161330 sameAs 2125161330 @default.
• W2125161330 citedByCount "164" @default.
• W2125161330 countsByYear W21251613302012 @default.
• W2125161330 countsByYear W21251613302013 @default.
• W2125161330 countsByYear W21251613302014 @default.
• W2125161330 countsByYear W21251613302015 @default.
• W2125161330 countsByYear W21251613302016 @default.
• W2125161330 countsByYear W21251613302017 @default.
• W2125161330 countsByYear W21251613302018 @default.
• W2125161330 countsByYear W21251613302019 @default.
• W2125161330 countsByYear W21251613302020 @default.
• W2125161330 countsByYear W21251613302021 @default.
• W2125161330 countsByYear W21251613302022 @default.
• W2125161330 crossrefType "journal-article" @default.
• W2125161330 hasAuthorship W2125161330A5006014190 @default.
• W2125161330 hasAuthorship W2125161330A5009161164 @default.
• W2125161330 hasAuthorship W2125161330A5029196242 @default.
• W2125161330 hasAuthorship W2125161330A5031762888 @default.
• W2125161330 hasAuthorship W2125161330A5035054562 @default.
• W2125161330 hasAuthorship W2125161330A5051497173 @default.
• W2125161330 hasAuthorship W2125161330A5089876195 @default.
• W2125161330 hasBestOaLocation W21251613301 @default.
• W2125161330 hasConcept C104317684 @default.
• W2125161330 hasConcept C143065580 @default.
• W2125161330 hasConcept C153726182 @default.
• W2125161330 hasConcept C2775983634 @default.
• W2125161330 hasConcept C2780467176 @default.
• W2125161330 hasConcept C2780796267 @default.
• W2125161330 hasConcept C2781090273 @default.
• W2125161330 hasConcept C54355233 @default.

• next