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• W2125186408 abstract "The interaction of patulin with human serum albumin (HSA) was studied in vitro under normal physiological conditions. The study was performed using fluorescence, ultraviolet-visible spectroscopy (UV-Vis), circular dichroism (CD), atomic force microscopy (AFM), and molecular modeling techniques. The quenching mechanism was investigated using the association constants, the number of binding sites, and basic thermodynamic parameters. A dynamic quenching mechanism occurred between HSA and patulin, and the binding constants ( K ) were 2.60 × 10 4 , 4.59 × 10 4 , and 7.01 × 10 4 M −1 at 288, 300, and 310 K, respectively. Based on fluorescence resonance energy transfer, the distance between the HSA and patulin was determined to be 2.847 nm. The<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>Δ</mml:mi><mml:msup><mml:mrow><mml:mi>G</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle=italic>0</mml:mn></mml:mrow></mml:msup></mml:math>,<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>Δ</mml:mi><mml:msup><mml:mrow><mml:mi>H</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle=italic>0</mml:mn></mml:mrow></mml:msup></mml:math>, and<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>Δ</mml:mi><mml:msup><mml:mrow><mml:mi>S</mml:mi></mml:mrow><mml:mrow><mml:mn fontstyle=italic>0</mml:mn></mml:mrow></mml:msup></mml:math>values across various temperatures indicated that hydrophobic interaction was the predominant binding force. The UV-Vis and CD results confirmed that the secondary structure of HSA was altered in the presence of patulin. The AFM results revealed that the individual HSA molecule dimensions were larger after interaction with patulin. In addition, molecular modeling showed that the patulin-HSA complex was stabilized by hydrophobic and hydrogen bond forces. The study results suggested that a weak intermolecular interaction occurred between patulin and HSA. Overall, the results are potentially useful for elucidating the toxigenicity of patulin when it is combined with the biomolecular function effect, transmembrane transport, toxicological, testing and other experiments." @default.
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• W2125186408 date "2014-01-01" @default.
• W2125186408 modified "2023-10-12" @default.
• W2125186408 title "Investigation of the Interaction between Patulin and Human Serum Albumin by a Spectroscopic Method, Atomic Force Microscopy, and Molecular Modeling" @default.
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• W2125186408 doi "https://doi.org/10.1155/2014/734850" @default.
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