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• W2125193669 abstract "1. By using continuous infusions of 3 H- and 14 C-labelled substrates, three-pool models, incorporating rumen propionate, plasma glucose and blood carbon dioxide were constructed to determine the contribution of propionate to glucose in non-pregnant, pregnant (mid and late) and lactating hill ewes. 2. Although the intakes of non-pregnant and pregnant ewes were the same (1200 g driedgrass/d) and resulted in similar levels of propionate production (33 g C/d), glucose production rate (GPR) increased from 44 g C/d in the non-pregnant ewes to 62 g C/d in the ewes carrying twins in late pregnancy. In lactating ewes given 2500 g dried grass/d, propionate production increased to 56 g C/d and GPR increased to 93 and 104 g C/d in ewes suckling single and twin lambs respectively. 3. There was an increase in the percentage of the propionate resource which was diverted to glucose, from 37% in the non-pregnant ewes and ewes in mid-pregnancy, to 55% in late pregnancy and 60% in lactation. In spite of this apparent metabolic adaptation to the additional requirements for glucose, approximately 55% of the glucose-C was supplied by metabolites other than propionate and CO 2 . 4. From the determination of plasma glycerol concentrations it was estimated that themaximum possible contribution of glycerol-C to glucose was only 8–12 g C/d. Theremaining 40% of the glucose-C could not be accounted for and could have been derived from non-essential amino acids (NEAA). 5. In the non-pregnant and pregnant ewes only 62% of the GPR was oxidized to CO 2 . In the lactating ewes only 49 and 30% of the GPR was oxidized to CO 2 in the ewes suckling single and twin lambs respectively. 6. In the majority of cases there was a marked similarity between the amounts of glucose-C apparently derived from NEAA and the amount of glucose-C which was not oxidized to CO 2 ." @default.
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• W2125193669 date "1983-09-01" @default.
• W2125193669 modified "2023-10-16" @default.
• W2125193669 title "Glucose production and utilization in non-pregnant, pregnant and lactating ewes" @default.
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• W2125193669 doi "https://doi.org/10.1079/bjn19830098" @default.
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