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• W2125195379 abstract "<b>Objective:</b> To determine whether longitudinal left ventricular systolic function measured by Doppler tissue imaging (DTI) after exercise can identify early left ventricular dysfunction in asymptomatic patients with moderate–severe aortic stenosis. <b>Design:</b> Case–control study. <b>Setting:</b> Outpatient cardiology departments. <b>Patients:</b> 20 patients with aortic stenosis, with or without equivocal symptoms, a peak aortic valve velocity ⩾3 m/s, and left ventricular ejection fraction >50% and 15 aged-matched normal controls. <b>Interventions:</b> Echocardiogram performed at rest and immediately after treadmill exercise. <b>Main outcome measures:</b> The peak systolic velocity of the lateral mitral annulus (S’) by DTI at rest and immediately after exercise, exercise capacity, exercise systolic blood pressure and the plasma level of B-type natriuretic peptide (BNP). <b>Results:</b> For patients with aortic stenosis, mean (SD) aortic valve area was 0.95 (0.3) cm². At rest, S’ was similar for patients with aortic stenosis and controls, respectively (8.5 (1.5) vs 9.1 (1.8) cm/s, p = 0.15). However, after exercise, S’ (12.2 (3.2) vs 17 (2.8) cm/s, p<0.001) and the increase in S’ between rest and exercise (4 (3) vs 7.9 (1.5) cm/s, p<0.001) were lower in patients with aortic stenosis. In patients with aortic stenosis, a smaller increase in S’ after exercise was associated with lower exercise capacity (r = 0.5, p = 0.02), a smaller increase in exercise systolic blood pressure (r = 0.6, p = 0.005) and higher plasma level of BNP (r = 0.66, p = 0.002). <b>Conclusion:</b> In asymptomatic patients with moderate–severe aortic stenosis a lower than normal increase in peak systolic mitral annular velocity after treadmill exercise is a marker of early left ventricular systolic dysfunction." @default.
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• W2125195379 date "2007-06-01" @default.
• W2125195379 modified "2023-09-26" @default.
• W2125195379 title "Longitudinal left ventricular contractile dysfunction after exercise in aortic stenosis" @default.
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• W2125195379 doi "https://doi.org/10.1136/hrt.2006.100164" @default.
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