FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125204079> ?p ?o ?g. }

• W2125204079 abstract "It is mandatory to confirm the absence of mutations in the KRAS gene before treating metastatic colorectal cancers with epidermal growth factor receptor inhibitors, and similar regulations are being considered for non-small cell lung carcinomas (NSCLC) and other tumor types. Routine diagnosis of KRAS mutations in NSCLC is challenging because of compromised quantity and quality of biological material. Although there are several methods available for detecting mutations in KRAS, there is little comparative data regarding their analytical performance, economic merits, and workflow parameters.We compared the specificity, sensitivity, cost, and working time of five methods using 131 frozen NSCLC tissue samples. We extracted genomic DNA from the samples and compared the performance of Sanger cycle sequencing, Pyrosequencing, High-resolution melting analysis (HRM), and the Conformité Européenne (CE)-marked TheraScreen DxS and K-ras StripAssay kits.Our results demonstrate that TheraScreen DxS and the StripAssay, in that order, were most effective at diagnosing mutations in KRAS. However, there were still unsatisfactory disagreements between them for 6.1% of all samples tested. Despite this, our findings are likely to assist molecular biologists in making rational decisions when selecting a reliable, efficient, and cost-effective method for detecting KRAS mutations in heterogeneous clinical tumor samples." @default.
• W2125204079 created "2016-06-24" @default.
• W2125204079 creator A5003209774 @default.
• W2125204079 creator A5003843554 @default.
• W2125204079 creator A5005324730 @default.
• W2125204079 creator A5008432838 @default.
• W2125204079 creator A5012142431 @default.
• W2125204079 creator A5016827125 @default.
• W2125204079 creator A5023049602 @default.
• W2125204079 creator A5023455534 @default.
• W2125204079 creator A5033599838 @default.
• W2125204079 creator A5048228595 @default.
• W2125204079 creator A5071434659 @default.
• W2125204079 creator A5075448744 @default.
• W2125204079 date "2012-09-20" @default.
• W2125204079 modified "2023-10-16" @default.
• W2125204079 title "A comparison of Direct sequencing, Pyrosequencing, High resolution melting analysis, TheraScreen DxS, and the K-ras StripAssay for detecting KRAS mutations in non small cell lung carcinomas" @default.
• W2125204079 cites W136458434 @default.
• W2125204079 cites W1653677725 @default.
• W2125204079 cites W1658221551 @default.
• W2125204079 cites W1893137636 @default.
• W2125204079 cites W1993739082 @default.
• W2125204079 cites W1997860952 @default.
• W2125204079 cites W1999336249 @default.
• W2125204079 cites W2001691361 @default.
• W2125204079 cites W2007349736 @default.
• W2125204079 cites W2008530215 @default.
• W2125204079 cites W2017576089 @default.
• W2125204079 cites W2030488226 @default.
• W2125204079 cites W2041305941 @default.
• W2125204079 cites W2049550983 @default.
• W2125204079 cites W2053817374 @default.
• W2125204079 cites W2071251869 @default.
• W2125204079 cites W2088141524 @default.
• W2125204079 cites W2096504879 @default.
• W2125204079 cites W2100421179 @default.
• W2125204079 cites W2104811705 @default.
• W2125204079 cites W2110389586 @default.
• W2125204079 cites W2120490763 @default.
• W2125204079 cites W2130849650 @default.
• W2125204079 cites W2138468350 @default.
• W2125204079 cites W2141190489 @default.
• W2125204079 cites W2145927385 @default.
• W2125204079 cites W2146775979 @default.
• W2125204079 cites W2148408838 @default.
• W2125204079 cites W2156584992 @default.
• W2125204079 cites W2158843184 @default.
• W2125204079 cites W2162105023 @default.
• W2125204079 cites W2163195607 @default.
• W2125204079 cites W2167539263 @default.
• W2125204079 cites W2169191049 @default.
• W2125204079 cites W2170639289 @default.
• W2125204079 cites W67642703 @default.
• W2125204079 doi "https://doi.org/10.1186/1756-9966-31-79" @default.
• W2125204079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3542008" @default.
• W2125204079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22995035" @default.
• W2125204079 hasPublicationYear "2012" @default.
• W2125204079 type Work @default.
• W2125204079 sameAs 2125204079 @default.
• W2125204079 citedByCount "43" @default.
• W2125204079 countsByYear W21252040792013 @default.
• W2125204079 countsByYear W21252040792014 @default.
• W2125204079 countsByYear W21252040792015 @default.
• W2125204079 countsByYear W21252040792016 @default.
• W2125204079 countsByYear W21252040792017 @default.
• W2125204079 countsByYear W21252040792018 @default.
• W2125204079 countsByYear W21252040792019 @default.
• W2125204079 countsByYear W21252040792020 @default.
• W2125204079 countsByYear W21252040792022 @default.
• W2125204079 countsByYear W21252040792023 @default.
• W2125204079 crossrefType "journal-article" @default.
• W2125204079 hasAuthorship W2125204079A5003209774 @default.
• W2125204079 hasAuthorship W2125204079A5003843554 @default.
• W2125204079 hasAuthorship W2125204079A5005324730 @default.
• W2125204079 hasAuthorship W2125204079A5008432838 @default.
• W2125204079 hasAuthorship W2125204079A5012142431 @default.
• W2125204079 hasAuthorship W2125204079A5016827125 @default.
• W2125204079 hasAuthorship W2125204079A5023049602 @default.
• W2125204079 hasAuthorship W2125204079A5023455534 @default.
• W2125204079 hasAuthorship W2125204079A5033599838 @default.
• W2125204079 hasAuthorship W2125204079A5048228595 @default.
• W2125204079 hasAuthorship W2125204079A5071434659 @default.
• W2125204079 hasAuthorship W2125204079A5075448744 @default.
• W2125204079 hasBestOaLocation W21252040791 @default.
• W2125204079 hasConcept C104317684 @default.
• W2125204079 hasConcept C121608353 @default.
• W2125204079 hasConcept C125009961 @default.
• W2125204079 hasConcept C126322002 @default.
• W2125204079 hasConcept C2776256026 @default.
• W2125204079 hasConcept C2781187634 @default.
• W2125204079 hasConcept C34372108 @default.
• W2125204079 hasConcept C49105822 @default.
• W2125204079 hasConcept C502942594 @default.
• W2125204079 hasConcept C51679486 @default.
• W2125204079 hasConcept C526805850 @default.
• W2125204079 hasConcept C54355233 @default.
• W2125204079 hasConcept C70721500 @default.
• W2125204079 hasConcept C71924100 @default.
• W2125204079 hasConcept C76818968 @default.
• W2125204079 hasConcept C86803240 @default.

• next