Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125211458> ?p ?o ?g. }
- W2125211458 endingPage "871" @default.
- W2125211458 startingPage "858" @default.
- W2125211458 abstract "Thalamic nuclei can generate intrathalamic rhythms similar to those observed at various arousal levels and pathophysiological conditions such as absence epilepsy. These rhythmic activities can be altered by a variety of neuromodulators that arise from brain stem regions as well as those that are intrinsic to the thalamic circuitry. Vasoactive intestinal peptide (VIP) is a neuropeptide localized within the thalamus and strongly attenuates intrathalamic rhythms via an unidentified receptor subtype. We have used transgenic mice lacking a specific VIP receptor, VPAC 2 , to identify its role in VIP-mediated actions in the thalamus. VIP strongly attenuated both the slow, 2–4 Hz and spindle-like 5–8 Hz rhythmic activities in slices from wild-type mice (VPAC 2 +/+ ) but not in slices from VPAC 2 receptor knock-out mice (VPAC 2 −/− ), which suggests a major role of VPAC 2 receptors in the antioscillatory actions of VIP. Intracellular recordings revealed that VIP depolarized all relay neurons tested from VPAC 2 +/+ mice. In VPAC 2 −/− mice, however, VIP produced no membrane depolarization in 80% of neurons tested. In relay neurons from VPAC 2 +/+ mice, VIP enhanced the hyperpolarization-activated mixed cation current, I h , via cyclic AMP activity, but VIP did not alter I h in VPAC 2 −/− mice. In VPAC 2 −/− mice, pituitary adenylate cyclase activating-polypeptide (PACAP) depolarized the majority of relay neurons via I h enhancement presumably via PAC 1 receptor activation. Our findings suggest that VIP-mediated actions are predominantly mediated by VPAC 2 receptors, but PAC 1 receptors may play a minor role. The excitatory actions of VIP and PACAP suggest these peptides may not only regulate intrathalamic rhythmic activities, but also may influence information transfer through thalamocortical circuits." @default.
- W2125211458 created "2016-06-24" @default.
- W2125211458 creator A5041479251 @default.
- W2125211458 creator A5055100242 @default.
- W2125211458 date "2006-08-01" @default.
- W2125211458 modified "2023-09-23" @default.
- W2125211458 title "Excitatory Actions of Vasoactive Intestinal Peptide on Mouse Thalamocortical Neurons Are Mediated by VPAC<sub>2</sub>Receptors" @default.
- W2125211458 cites W1490159759 @default.
- W2125211458 cites W1527707083 @default.
- W2125211458 cites W1531289420 @default.
- W2125211458 cites W1751495803 @default.
- W2125211458 cites W1852779583 @default.
- W2125211458 cites W1852928000 @default.
- W2125211458 cites W1951178950 @default.
- W2125211458 cites W1969382336 @default.
- W2125211458 cites W1969880485 @default.
- W2125211458 cites W1974549206 @default.
- W2125211458 cites W1979067492 @default.
- W2125211458 cites W1981423842 @default.
- W2125211458 cites W1987022586 @default.
- W2125211458 cites W1990422815 @default.
- W2125211458 cites W1992669875 @default.
- W2125211458 cites W1994962594 @default.
- W2125211458 cites W1999921358 @default.
- W2125211458 cites W2000954136 @default.
- W2125211458 cites W2001010206 @default.
- W2125211458 cites W2002189290 @default.
- W2125211458 cites W2003591641 @default.
- W2125211458 cites W2005863324 @default.
- W2125211458 cites W2008620248 @default.
- W2125211458 cites W2012062796 @default.
- W2125211458 cites W2013169579 @default.
- W2125211458 cites W2024697593 @default.
- W2125211458 cites W2028311911 @default.
- W2125211458 cites W2032202532 @default.
- W2125211458 cites W2034355463 @default.
- W2125211458 cites W2041538618 @default.
- W2125211458 cites W2044937225 @default.
- W2125211458 cites W2046300633 @default.
- W2125211458 cites W2048266255 @default.
- W2125211458 cites W2049040467 @default.
- W2125211458 cites W2049059486 @default.
- W2125211458 cites W2053820746 @default.
- W2125211458 cites W2057313983 @default.
- W2125211458 cites W2059459614 @default.
- W2125211458 cites W2062937788 @default.
- W2125211458 cites W2071922413 @default.
- W2125211458 cites W2077149536 @default.
- W2125211458 cites W2078889926 @default.
- W2125211458 cites W2084256019 @default.
- W2125211458 cites W2086831790 @default.
- W2125211458 cites W2094105588 @default.
- W2125211458 cites W2096882849 @default.
- W2125211458 cites W2098204603 @default.
- W2125211458 cites W2098560768 @default.
- W2125211458 cites W2100941719 @default.
- W2125211458 cites W2104393746 @default.
- W2125211458 cites W2109746889 @default.
- W2125211458 cites W2110585018 @default.
- W2125211458 cites W2111493429 @default.
- W2125211458 cites W2112196515 @default.
- W2125211458 cites W2112573636 @default.
- W2125211458 cites W2116190393 @default.
- W2125211458 cites W2124025293 @default.
- W2125211458 cites W2137303544 @default.
- W2125211458 cites W2138511032 @default.
- W2125211458 cites W2145321763 @default.
- W2125211458 cites W2153267851 @default.
- W2125211458 cites W2156837840 @default.
- W2125211458 cites W2160088320 @default.
- W2125211458 cites W2163694327 @default.
- W2125211458 cites W2164701017 @default.
- W2125211458 cites W2165892338 @default.
- W2125211458 cites W2169221312 @default.
- W2125211458 cites W2171302374 @default.
- W2125211458 cites W2400961508 @default.
- W2125211458 cites W4229627221 @default.
- W2125211458 cites W4236558664 @default.
- W2125211458 cites W4361743021 @default.
- W2125211458 cites W2092907517 @default.
- W2125211458 doi "https://doi.org/10.1152/jn.01115.2005" @default.
- W2125211458 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16641377" @default.
- W2125211458 hasPublicationYear "2006" @default.
- W2125211458 type Work @default.
- W2125211458 sameAs 2125211458 @default.
- W2125211458 citedByCount "13" @default.
- W2125211458 countsByYear W21252114582013 @default.
- W2125211458 countsByYear W21252114582015 @default.
- W2125211458 countsByYear W21252114582021 @default.
- W2125211458 countsByYear W21252114582022 @default.
- W2125211458 crossrefType "journal-article" @default.
- W2125211458 hasAuthorship W2125211458A5041479251 @default.
- W2125211458 hasAuthorship W2125211458A5055100242 @default.
- W2125211458 hasConcept C118303440 @default.
- W2125211458 hasConcept C126322002 @default.
- W2125211458 hasConcept C134018914 @default.
- W2125211458 hasConcept C169760540 @default.
- W2125211458 hasConcept C170493617 @default.