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- W2125228110 abstract "AbstractIntroduction. Subjects with asthma frequently have nasal symptoms and complain of orthopnoea but airflow resistance is usually only assessed during oral breathing and while seated. Method. We have used a forced oscillation technique to measure total respiratory resistance (Rrs) at 6Hz during mouth breathing (Rrs,mo) and during nose breathing (Rrs,na) in the sitting and supine postures; resistance of the nasal airway (Rnaw) was estimated as Rrs,na − Rrs,mo. Forced oscillations were applied during normal tidal breathing and the mid‐tidal lung volume (MTLV) was determined for each breathing route and posture. Subjects. Three groups of subjects were studied: 10 normal subjects without lung or nasal disease (N; five males, mean age 33.5 [range 23–58] years, mean FEV1 105%pred, FEV1/VC 86%); seven subjects with asthma alone (A; four males, 40.3 [23–57] years, mean FEV1 66%pred, FEV1/VC 74%); 10 asthmatic subjects with nasal obstructive symptoms (AN; six males, 62.8 [38–80] years, mean FEV1 56%pred, FEV1/VC 75%). Results. In all three groups of subjects, mean Rrs,mo and Rrs,na were higher in the supine than sitting posture. In normal subjects the increase in supine Rrs,mo was associated with a 0.6 liter fall in MTLV. In asthma supine Rrs,mo increased despite a much smaller fall in MTLV; supine increases in Rrs,na were particularly large in presence of nasal disease. Discussion. Values of airflow resistance are 2–3 times higher in both normal and asthmatic subjects when breathing via the nose and supine than under normal laboratory conditions of oral breathing and seated.KEYWORDS: Nasal symptomsSitting and supine posturesPulmonary resistance" @default.
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- W2125228110 date "2004-01-01" @default.
- W2125228110 modified "2023-10-06" @default.
- W2125228110 title "Postural Changes in Nasal and Pulmonary Resistance in Subjects with Asthma" @default.
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- W2125228110 doi "https://doi.org/10.1081/jas-200027820" @default.
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