Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125236475> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2125236475 abstract "Primary liver cancers are classified into three types based on their morphology and cytogenetic characteristics hepatocellular carcinoma (HCC), intrahepatic cholangiocarcinoma (ICC) and combined hepatocellular and cholangiocarcinoma (CHC). It is often difficult to distinguish these liver tumors. Glypican-3 (GPC3) is serological and histochemical marker of hepatocellular carcinoma. In order to separate these three types of liver cancers, we analyzed the GPC3 expression in 85 liver resection specimens, including 46 HCCs, 28 ICCs and 11 CHCs. GPC3 immunohistochemical staining was used to distinguish HCC from ICC by comparing with the conventional biomarker, α-fetoprotein (AFP). The immunostaining of GPC3 was identified in 78.3% (36/46) of HCCs, 60% (9/15) of well differentiated, 88.9% (16/18) of moderately differentiated and 84.6% (11/13) of poorly differentiated HCCs. It was negative in the ICCs. We confirmed that GPC3 expression is specific to HCC component (8/11, 72.7%) but few samples also showed weakly in ICC component (2/11, 18.2%) of CHC sections among 11 cases compared with HCC biomarkers including AFP and hepatocyto paraffin 1 (HepPar1), and ICC biomarkers cytokeratin (CK) 7 and CK19. Three cases in which the macroscopic features resembled ICC did not express GPC3 even in the pathological HCC component. Most (10/11, 91%) of the pathological cholangiocarcinoma components in CHC showed positive staining for CK7 and CK19. The results of this study suggest that GPC3 is a biomarker that is sensitive and specific to HCC component of CHC, and CK7 and CK19 are markers for pathological cholangiocarcinoma component of CHC." @default.
- W2125236475 created "2016-06-24" @default.
- W2125236475 creator A5000097972 @default.
- W2125236475 date "2009-02-09" @default.
- W2125236475 modified "2023-10-01" @default.
- W2125236475 title "Glypican-3 is a useful diagnostic marker for a component of hepatocellular carcinoma in human liver cancer" @default.
- W2125236475 doi "https://doi.org/10.3892/ijo_00000190" @default.
- W2125236475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19212669" @default.
- W2125236475 hasPublicationYear "2009" @default.
- W2125236475 type Work @default.
- W2125236475 sameAs 2125236475 @default.
- W2125236475 citedByCount "44" @default.
- W2125236475 countsByYear W21252364752012 @default.
- W2125236475 countsByYear W21252364752013 @default.
- W2125236475 countsByYear W21252364752014 @default.
- W2125236475 countsByYear W21252364752015 @default.
- W2125236475 countsByYear W21252364752016 @default.
- W2125236475 countsByYear W21252364752017 @default.
- W2125236475 countsByYear W21252364752018 @default.
- W2125236475 countsByYear W21252364752019 @default.
- W2125236475 countsByYear W21252364752020 @default.
- W2125236475 countsByYear W21252364752021 @default.
- W2125236475 countsByYear W21252364752022 @default.
- W2125236475 countsByYear W21252364752023 @default.
- W2125236475 crossrefType "journal-article" @default.
- W2125236475 hasAuthorship W2125236475A5000097972 @default.
- W2125236475 hasBestOaLocation W21252364751 @default.
- W2125236475 hasConcept C121608353 @default.
- W2125236475 hasConcept C126322002 @default.
- W2125236475 hasConcept C142724271 @default.
- W2125236475 hasConcept C204232928 @default.
- W2125236475 hasConcept C2776231280 @default.
- W2125236475 hasConcept C2778019345 @default.
- W2125236475 hasConcept C2779012181 @default.
- W2125236475 hasConcept C2779314089 @default.
- W2125236475 hasConcept C2779742787 @default.
- W2125236475 hasConcept C2781197716 @default.
- W2125236475 hasConcept C2909135397 @default.
- W2125236475 hasConcept C4224716 @default.
- W2125236475 hasConcept C502942594 @default.
- W2125236475 hasConcept C55493867 @default.
- W2125236475 hasConcept C71924100 @default.
- W2125236475 hasConcept C86803240 @default.
- W2125236475 hasConceptScore W2125236475C121608353 @default.
- W2125236475 hasConceptScore W2125236475C126322002 @default.
- W2125236475 hasConceptScore W2125236475C142724271 @default.
- W2125236475 hasConceptScore W2125236475C204232928 @default.
- W2125236475 hasConceptScore W2125236475C2776231280 @default.
- W2125236475 hasConceptScore W2125236475C2778019345 @default.
- W2125236475 hasConceptScore W2125236475C2779012181 @default.
- W2125236475 hasConceptScore W2125236475C2779314089 @default.
- W2125236475 hasConceptScore W2125236475C2779742787 @default.
- W2125236475 hasConceptScore W2125236475C2781197716 @default.
- W2125236475 hasConceptScore W2125236475C2909135397 @default.
- W2125236475 hasConceptScore W2125236475C4224716 @default.
- W2125236475 hasConceptScore W2125236475C502942594 @default.
- W2125236475 hasConceptScore W2125236475C55493867 @default.
- W2125236475 hasConceptScore W2125236475C71924100 @default.
- W2125236475 hasConceptScore W2125236475C86803240 @default.
- W2125236475 hasIssue "3" @default.
- W2125236475 hasLocation W21252364751 @default.
- W2125236475 hasLocation W21252364752 @default.
- W2125236475 hasOpenAccess W2125236475 @default.
- W2125236475 hasPrimaryLocation W21252364751 @default.
- W2125236475 hasRelatedWork W1883251460 @default.
- W2125236475 hasRelatedWork W202920663 @default.
- W2125236475 hasRelatedWork W2071293706 @default.
- W2125236475 hasRelatedWork W2088783977 @default.
- W2125236475 hasRelatedWork W2125236475 @default.
- W2125236475 hasRelatedWork W2346103388 @default.
- W2125236475 hasRelatedWork W2369101050 @default.
- W2125236475 hasRelatedWork W2396349469 @default.
- W2125236475 hasRelatedWork W3088310914 @default.
- W2125236475 hasRelatedWork W3093061551 @default.
- W2125236475 hasVolume "34" @default.
- W2125236475 isParatext "false" @default.
- W2125236475 isRetracted "false" @default.
- W2125236475 magId "2125236475" @default.
- W2125236475 workType "article" @default.