Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125243669> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W2125243669 endingPage "129" @default.
- W2125243669 startingPage "129" @default.
- W2125243669 abstract "Several human lung tumor cell lines derived from large cell, squamous cell, and small cell carcinomas, as well as from mesotheliomas of the lung have been investigated for their gene expression and secretion of urokinase-type plasminogen activator (u-PA), tissue-type plasminogen activator (t-PA), and plasminogen activator inhibitors 1 and 2. All bronchogenic non-small cell carcinoma-derived cell lines studied could produce either plasminogen activators, their inhibitors, or both components, whereas in small cell lung carcinoma cell lines and cell lines derived from mesothelioma of the lung, no substantial amounts of any of these substances were synthesized. In detail, a large cell carcinoma-derived cell line, LCLC 97TM1, constitutively secreted large amounts of plasminogen activator. Northern blot analysis revealed RNA specific for u-PA and t-PA. Another large cell carcinoma-derived cell line, LCLC 103H, secreted smaller amounts of plasminogen activator and, additionally, plasminogen activator inhibitor. Specific mRNAs for u-PA and plasminogen activator inhibitors 1 and 2 were found in this cell line. In contrast, squamous cell carcinoma-derived cell lines secreted plasminogen activator only after treatment with the phorbol ester 12-O-tetradecanoylphorbol-13-acetate; enhanced levels of u-PA, t-PA, and plasminogen activator inhibitor 1 mRNAs could then be demonstrated. The different expression of the plasminogen activator enzyme system distinguishes cell lines derived of non-small cell lung carcinoma from those of small cell lung carcinoma and may also reflect significant differences in the biological behavior of these tumor types." @default.
- W2125243669 created "2016-06-24" @default.
- W2125243669 creator A5023401611 @default.
- W2125243669 creator A5025119363 @default.
- W2125243669 creator A5043020345 @default.
- W2125243669 creator A5069379445 @default.
- W2125243669 creator A5071204995 @default.
- W2125243669 creator A5074611577 @default.
- W2125243669 date "1990-10-01" @default.
- W2125243669 modified "2023-09-23" @default.
- W2125243669 title "Synthesis and secretion of plasminogen activators and plasminogen activator inhibitors in cell lines of different groups of human lung tumors" @default.
- W2125243669 doi "https://doi.org/10.1016/0169-5002(90)90170-q" @default.
- W2125243669 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2555056" @default.
- W2125243669 hasPublicationYear "1990" @default.
- W2125243669 type Work @default.
- W2125243669 sameAs 2125243669 @default.
- W2125243669 citedByCount "14" @default.
- W2125243669 crossrefType "journal-article" @default.
- W2125243669 hasAuthorship W2125243669A5023401611 @default.
- W2125243669 hasAuthorship W2125243669A5025119363 @default.
- W2125243669 hasAuthorship W2125243669A5043020345 @default.
- W2125243669 hasAuthorship W2125243669A5069379445 @default.
- W2125243669 hasAuthorship W2125243669A5071204995 @default.
- W2125243669 hasAuthorship W2125243669A5074611577 @default.
- W2125243669 hasConcept C104317684 @default.
- W2125243669 hasConcept C134018914 @default.
- W2125243669 hasConcept C1491633281 @default.
- W2125243669 hasConcept C153911025 @default.
- W2125243669 hasConcept C2779679481 @default.
- W2125243669 hasConcept C2780675426 @default.
- W2125243669 hasConcept C49039625 @default.
- W2125243669 hasConcept C502942594 @default.
- W2125243669 hasConcept C54355233 @default.
- W2125243669 hasConcept C55493867 @default.
- W2125243669 hasConcept C81885089 @default.
- W2125243669 hasConcept C86803240 @default.
- W2125243669 hasConcept C88045685 @default.
- W2125243669 hasConceptScore W2125243669C104317684 @default.
- W2125243669 hasConceptScore W2125243669C134018914 @default.
- W2125243669 hasConceptScore W2125243669C1491633281 @default.
- W2125243669 hasConceptScore W2125243669C153911025 @default.
- W2125243669 hasConceptScore W2125243669C2779679481 @default.
- W2125243669 hasConceptScore W2125243669C2780675426 @default.
- W2125243669 hasConceptScore W2125243669C49039625 @default.
- W2125243669 hasConceptScore W2125243669C502942594 @default.
- W2125243669 hasConceptScore W2125243669C54355233 @default.
- W2125243669 hasConceptScore W2125243669C55493867 @default.
- W2125243669 hasConceptScore W2125243669C81885089 @default.
- W2125243669 hasConceptScore W2125243669C86803240 @default.
- W2125243669 hasConceptScore W2125243669C88045685 @default.
- W2125243669 hasIssue "3-4" @default.
- W2125243669 hasLocation W21252436691 @default.
- W2125243669 hasLocation W21252436692 @default.
- W2125243669 hasOpenAccess W2125243669 @default.
- W2125243669 hasPrimaryLocation W21252436691 @default.
- W2125243669 hasRelatedWork W1567181801 @default.
- W2125243669 hasRelatedWork W1568470529 @default.
- W2125243669 hasRelatedWork W160128134 @default.
- W2125243669 hasRelatedWork W1973413312 @default.
- W2125243669 hasRelatedWork W2013584203 @default.
- W2125243669 hasRelatedWork W2060570783 @default.
- W2125243669 hasRelatedWork W2135959956 @default.
- W2125243669 hasRelatedWork W2147608460 @default.
- W2125243669 hasRelatedWork W2361134997 @default.
- W2125243669 hasRelatedWork W2401673772 @default.
- W2125243669 hasVolume "6" @default.
- W2125243669 isParatext "false" @default.
- W2125243669 isRetracted "false" @default.
- W2125243669 magId "2125243669" @default.
- W2125243669 workType "article" @default.