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• W2125247619 abstract "The objective of this study was to investigate the effects of sodium lauryl sulfate (SLS) from different sources on solubilization/wetting, granulation process, and tablet dissolution of BILR 355 and the potential causes.The particle size distribution, morphology, and thermal behaviors of two pharmaceutical grades of SLS from Spectrum and Cognis were characterized. The surface tension and drug solubility in SLS solutions were measured. The BILR 355 tablets were prepared by a wet granulation process and the dissolution was evaluated.The critical micelle concentration was lower for Spectrum SLS, which resulted in a higher BILR 355 solubility. During wet granulation, less water was required to reach the same end point using Spectrum than Cognis SLS. In general, BILR 355 tablets prepared with Spectrum SLS showed a higher dissolution than the tablets containing Cognis SLS. Micronization of SLS achieved the same improved tablet dissolution as micronized active pharmaceutical ingredient.The observed differences in wetting and solubilization were likely due to the different impurity levels in SLS from two sources. This study demonstrated that SLS from different sources could have significant impact on wet granulation process and dissolution. Therefore, it is critical to evaluate SLS properties from different suppliers, and then identify optimal formulation and process parameters to ensure robustness of drug product manufacture process and performance." @default.
• W2125247619 created "2016-06-24" @default.
• W2125247619 creator A5055630665 @default.
• W2125247619 creator A5055938786 @default.
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• W2125247619 date "2010-06-14" @default.
• W2125247619 modified "2023-10-01" @default.
• W2125247619 title "Evaluation of the impact of sodium lauryl sulfate source variability on solid oral dosage form development" @default.
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• W2125247619 doi "https://doi.org/10.3109/03639045.2010.488647" @default.
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• W2125247619 hasPublicationYear "2010" @default.
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