FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125280399> ?p ?o ?g. }

• W2125280399 endingPage "1656" @default.
• W2125280399 startingPage "1644" @default.
• W2125280399 abstract "Podocyte apoptosis initiates progressive glomerulosclerosis in TGF-β1 transgenic and CD2AP-knockout (CD2AP−/−) mice. It was previously shown that in both mouse models, activation of the TGF-β pathway is the key event during development of podocyte apoptosis. Furthermore, CD2AP is an important modifier of TGF-β–induced survival signaling <i>via</i> activation of the phosphoinositol 3-kinase/AKT signaling pathway. This article presents IGF-binding protein-3 (IGFBP-3) as a new modulator of apoptosis and survival signaling in glomerular podocytes. High expression of IGFBP-3 protein in the urine of diseased CD2AP−/− mice was discovered, and IGFBP-3 expression in glomerular podocytes and parietal cells was detected. IGFBP-3 can induce changes in podocyte actin cytoskeleton, leads to apoptosis in cultured murine podocytes, and can enhance TGF-β1–induced apoptosis <i>in vitro</i>. For studying this process on a molecular level, proapoptotic p38 mitogen-activated protein kinase pathways and antiapoptotic phosphoinositol 3-kinase/AKT pathways were examined in cultured murine podocytes. It was found that IGFBP-3 increments the level of TGF-β1–induced phosphorylated p38 mitogen-activated protein kinase and decreases the phosphorylation of antiapoptotic AKT. This effect is specific for the co-stimulation of IGFBP-3 with TGF-β1 because a combination of IGFBP-3 with bone morphogenic protein-7 (BMP-7), another member of the TGF-β superfamily, results in apoptosis opposing signaling effects with a strong increase of phosphorylated AKT and subsequent functional effects. These results demonstrate that the IGF/IGFBP axis plays an important role in the development of podocyte apoptosis by modulation of TGF-β and BMP-7–induced pro- and antiapoptotic signals." @default.
• W2125280399 created "2016-06-24" @default.
• W2125280399 creator A5009990313 @default.
• W2125280399 creator A5012505167 @default.
• W2125280399 creator A5031841329 @default.
• W2125280399 creator A5044922692 @default.
• W2125280399 creator A5046399162 @default.
• W2125280399 creator A5051490000 @default.
• W2125280399 creator A5055944692 @default.
• W2125280399 creator A5056508114 @default.
• W2125280399 creator A5062825190 @default.
• W2125280399 creator A5067794863 @default.
• W2125280399 date "2006-06-01" @default.
• W2125280399 modified "2023-09-26" @default.
• W2125280399 title "IGF-Binding Protein-3 Modulates TGF-β/BMP-Signaling in Glomerular Podocytes" @default.
• W2125280399 cites W1636022999 @default.
• W2125280399 cites W1966022628 @default.
• W2125280399 cites W1986170576 @default.
• W2125280399 cites W1992172901 @default.
• W2125280399 cites W1993345123 @default.
• W2125280399 cites W1997806989 @default.
• W2125280399 cites W2001892266 @default.
• W2125280399 cites W2016977736 @default.
• W2125280399 cites W2020695173 @default.
• W2125280399 cites W2031800834 @default.
• W2125280399 cites W2046540619 @default.
• W2125280399 cites W2050595371 @default.
• W2125280399 cites W2066153697 @default.
• W2125280399 cites W2069840256 @default.
• W2125280399 cites W2077956417 @default.
• W2125280399 cites W2079773807 @default.
• W2125280399 cites W2080627387 @default.
• W2125280399 cites W2088874555 @default.
• W2125280399 cites W2097160036 @default.
• W2125280399 cites W2097887036 @default.
• W2125280399 cites W2108104357 @default.
• W2125280399 cites W2114245705 @default.
• W2125280399 cites W2115417003 @default.
• W2125280399 cites W2122219276 @default.
• W2125280399 cites W2128999719 @default.
• W2125280399 cites W2132803823 @default.
• W2125280399 cites W2143552853 @default.
• W2125280399 cites W2148446507 @default.
• W2125280399 cites W2153705946 @default.
• W2125280399 cites W2157230648 @default.
• W2125280399 cites W2168176104 @default.
• W2125280399 cites W2169570354 @default.
• W2125280399 cites W2170407972 @default.
• W2125280399 cites W2170723783 @default.
• W2125280399 cites W2217868403 @default.
• W2125280399 cites W2312485874 @default.
• W2125280399 cites W4237456857 @default.
• W2125280399 cites W4244095134 @default.
• W2125280399 cites W4245922091 @default.
• W2125280399 cites W4250315083 @default.
• W2125280399 cites W4255655686 @default.
• W2125280399 doi "https://doi.org/10.1681/asn.2005111209" @default.
• W2125280399 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16672319" @default.
• W2125280399 hasPublicationYear "2006" @default.
• W2125280399 type Work @default.
• W2125280399 sameAs 2125280399 @default.
• W2125280399 citedByCount "48" @default.
• W2125280399 countsByYear W21252803992012 @default.
• W2125280399 countsByYear W21252803992013 @default.
• W2125280399 countsByYear W21252803992014 @default.
• W2125280399 countsByYear W21252803992015 @default.
• W2125280399 countsByYear W21252803992016 @default.
• W2125280399 countsByYear W21252803992018 @default.
• W2125280399 countsByYear W21252803992019 @default.
• W2125280399 countsByYear W21252803992020 @default.
• W2125280399 countsByYear W21252803992021 @default.
• W2125280399 countsByYear W21252803992022 @default.
• W2125280399 countsByYear W21252803992023 @default.
• W2125280399 crossrefType "journal-article" @default.
• W2125280399 hasAuthorship W2125280399A5009990313 @default.
• W2125280399 hasAuthorship W2125280399A5012505167 @default.
• W2125280399 hasAuthorship W2125280399A5031841329 @default.
• W2125280399 hasAuthorship W2125280399A5044922692 @default.
• W2125280399 hasAuthorship W2125280399A5046399162 @default.
• W2125280399 hasAuthorship W2125280399A5051490000 @default.
• W2125280399 hasAuthorship W2125280399A5055944692 @default.
• W2125280399 hasAuthorship W2125280399A5056508114 @default.
• W2125280399 hasAuthorship W2125280399A5062825190 @default.
• W2125280399 hasAuthorship W2125280399A5067794863 @default.
• W2125280399 hasBestOaLocation W21252803991 @default.
• W2125280399 hasConcept C118131993 @default.
• W2125280399 hasConcept C11960822 @default.
• W2125280399 hasConcept C134018914 @default.
• W2125280399 hasConcept C2777146197 @default.
• W2125280399 hasConcept C2779561371 @default.
• W2125280399 hasConcept C2780091579 @default.
• W2125280399 hasConcept C502942594 @default.
• W2125280399 hasConcept C51551487 @default.
• W2125280399 hasConcept C62478195 @default.
• W2125280399 hasConcept C75217442 @default.
• W2125280399 hasConcept C86803240 @default.
• W2125280399 hasConcept C95444343 @default.
• W2125280399 hasConcept C97029542 @default.

• next