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• W2125291586 abstract "Stem cells are the target of mutations that can lead to life threatening diseases. However, stem cell populations tend to be small and therefore clonal expansion of mutant cells is highly sensitive to stochastic fluctuations. The evolutionary dynamics of mutations in these cells is discussed, taking into consideration the impact of such mutations on the reproductive fitness of cells. We show how stochastic effects can explain clinical observations, including extinction of acquired clonal stem cell disorders." @default.
• W2125291586 created "2016-06-24" @default.
• W2125291586 creator A5007747233 @default.
• W2125291586 creator A5073403497 @default.
• W2125291586 date "2011-06-07" @default.
• W2125291586 modified "2023-09-26" @default.
• W2125291586 title "Stochastic dynamics and the evolution of mutations in stem cells" @default.
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• W2125291586 doi "https://doi.org/10.1186/1741-7007-9-41" @default.
• W2125291586 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3110138" @default.
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• W2125291586 hasPublicationYear "2011" @default.
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