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• W2125291881 abstract "The incidence of Clostridium difficile-associated diarrhea (CDAD) has increased dramatically in hospitals worldwide during the past 2 decades. In Western Australia, this increase was most obvious during the 1980s, when there was also an increase in the use of third-generation cephalosporin antibiotics. A study of the epidemiology of CDAD and the use of third-generation cephalosporins during 1993-2000 was undertaken. From 1993 through 1998, the incidence of CDAD remained relatively stable (2-3 cases per 1000 discharges annually). Then, a significant decrease in the incidence occurred, from 2.09 cases per 1000 discharges (95% confidence interval [CI], 1.71-2.47) in 1998 to 0.87 cases per 1000 discharges (95% CI, 0.63-1.11) in 1999 (P<.0001); this decrease persisted into 2000. A decrease in third-generation cephalosporin use occurred during the period of the study because of changes in the prescribing policy. These findings suggest that a reduction in the use of third-generation cephalosporins can reduce the occurrence of CDAD." @default.
• W2125291881 created "2016-06-24" @default.
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• W2125291881 date "2002-12-15" @default.
• W2125291881 modified "2023-10-14" @default.
• W2125291881 title "<i>Clostridium difficile</i>–Associated Diarrhea: Epidemiological Data from Western Australia Associated with a Modified Antibiotic Policy" @default.
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• W2125291881 doi "https://doi.org/10.1086/342691" @default.
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