Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125302613> ?p ?o ?g. }
- W2125302613 endingPage "716" @default.
- W2125302613 startingPage "702" @default.
- W2125302613 abstract "POU-V class proteins like Oct4 are crucial for keeping cells in an undifferentiated state. An Oct4 homologue in Xenopus laevis, Oct25, peaks in expression during early gastrulation, when many cells are still uncommitted. Nevertheless, extensive morphogenesis is taking place in all germ layers at that time. Phenotypical analysis of embryos with Oct25 overexpression revealed morphogenesis defects, beginning during early gastrulation and resulting in spina-bifida-like axial defects. Analysis of marker genes and different morphogenesis assays show inhibitory effects on convergence and extension and on mesoderm internalization. On a cellular level, cell–cell adhesion is reduced. On a molecular level, Oct25 overexpression activates expression of PAPC, a functional inhibitor of the cell adhesion molecule EP/C-cadherin. Intriguingly, Oct25 effects on cell–cell adhesion can be restored by overexpression of EP/C-cadherin or by inhibition of the PAPC function. Thus, Oct25 affects morphogenesis via activation of PAPC expression and subsequent functional inhibition of EP/C-cadherin." @default.
- W2125302613 created "2016-06-24" @default.
- W2125302613 creator A5000467167 @default.
- W2125302613 creator A5005335589 @default.
- W2125302613 creator A5017791780 @default.
- W2125302613 creator A5037372673 @default.
- W2125302613 creator A5061388391 @default.
- W2125302613 date "2012-09-01" @default.
- W2125302613 modified "2023-10-17" @default.
- W2125302613 title "Pou-V factor Oct25 regulates early morphogenesis inXenopus laevis" @default.
- W2125302613 cites W1529745075 @default.
- W2125302613 cites W1539753443 @default.
- W2125302613 cites W1554884448 @default.
- W2125302613 cites W1608762409 @default.
- W2125302613 cites W1664587663 @default.
- W2125302613 cites W1972819493 @default.
- W2125302613 cites W1974365957 @default.
- W2125302613 cites W1975301960 @default.
- W2125302613 cites W1995140011 @default.
- W2125302613 cites W1998902161 @default.
- W2125302613 cites W2000394701 @default.
- W2125302613 cites W2000487866 @default.
- W2125302613 cites W2003922372 @default.
- W2125302613 cites W2008423079 @default.
- W2125302613 cites W2018528141 @default.
- W2125302613 cites W2024970033 @default.
- W2125302613 cites W2025853097 @default.
- W2125302613 cites W2026813670 @default.
- W2125302613 cites W2036326229 @default.
- W2125302613 cites W2038014989 @default.
- W2125302613 cites W2039815832 @default.
- W2125302613 cites W2042515526 @default.
- W2125302613 cites W2050520110 @default.
- W2125302613 cites W2053537144 @default.
- W2125302613 cites W2063503670 @default.
- W2125302613 cites W2065746091 @default.
- W2125302613 cites W2065920648 @default.
- W2125302613 cites W2075599049 @default.
- W2125302613 cites W2080165381 @default.
- W2125302613 cites W2081858053 @default.
- W2125302613 cites W2084376545 @default.
- W2125302613 cites W2091637225 @default.
- W2125302613 cites W2103740546 @default.
- W2125302613 cites W2105687707 @default.
- W2125302613 cites W2112833293 @default.
- W2125302613 cites W2115993158 @default.
- W2125302613 cites W2117270090 @default.
- W2125302613 cites W2125068279 @default.
- W2125302613 cites W2128135781 @default.
- W2125302613 cites W2131065802 @default.
- W2125302613 cites W2133677541 @default.
- W2125302613 cites W2140225613 @default.
- W2125302613 cites W2145934299 @default.
- W2125302613 cites W2147590629 @default.
- W2125302613 cites W2155292382 @default.
- W2125302613 cites W2157193608 @default.
- W2125302613 cites W2167226908 @default.
- W2125302613 cites W2167837165 @default.
- W2125302613 cites W2208796000 @default.
- W2125302613 cites W2234712136 @default.
- W2125302613 doi "https://doi.org/10.1111/j.1440-169x.2012.01371.x" @default.
- W2125302613 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22957893" @default.
- W2125302613 hasPublicationYear "2012" @default.
- W2125302613 type Work @default.
- W2125302613 sameAs 2125302613 @default.
- W2125302613 citedByCount "5" @default.
- W2125302613 countsByYear W21253026132013 @default.
- W2125302613 countsByYear W21253026132015 @default.
- W2125302613 countsByYear W21253026132016 @default.
- W2125302613 countsByYear W21253026132020 @default.
- W2125302613 crossrefType "journal-article" @default.
- W2125302613 hasAuthorship W2125302613A5000467167 @default.
- W2125302613 hasAuthorship W2125302613A5005335589 @default.
- W2125302613 hasAuthorship W2125302613A5017791780 @default.
- W2125302613 hasAuthorship W2125302613A5037372673 @default.
- W2125302613 hasAuthorship W2125302613A5061388391 @default.
- W2125302613 hasConcept C104317684 @default.
- W2125302613 hasConcept C107459253 @default.
- W2125302613 hasConcept C121587040 @default.
- W2125302613 hasConcept C127716648 @default.
- W2125302613 hasConcept C129536746 @default.
- W2125302613 hasConcept C137738243 @default.
- W2125302613 hasConcept C145103041 @default.
- W2125302613 hasConcept C1491633281 @default.
- W2125302613 hasConcept C149402561 @default.
- W2125302613 hasConcept C150194340 @default.
- W2125302613 hasConcept C18155467 @default.
- W2125302613 hasConcept C192586883 @default.
- W2125302613 hasConcept C196287685 @default.
- W2125302613 hasConcept C196843134 @default.
- W2125302613 hasConcept C2779535977 @default.
- W2125302613 hasConcept C2780915607 @default.
- W2125302613 hasConcept C40692019 @default.
- W2125302613 hasConcept C54355233 @default.
- W2125302613 hasConcept C85789140 @default.
- W2125302613 hasConcept C86803240 @default.
- W2125302613 hasConcept C87073359 @default.
- W2125302613 hasConcept C95444343 @default.