FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125302694> ?p ?o ?g. }

• W2125302694 endingPage "186" @default.
• W2125302694 startingPage "179" @default.
• W2125302694 abstract "Neutrophilic inflammation is an important pathologic feature of chronic obstructive pulmonary disease (COPD) and infectious exacerbations of COPD. Serum amyloid A (SAA) promotes neutrophilic inflammation by its interaction with lung mucosal ALX/FPR2 receptors. However, little is known about how this endogenous mediator regulates IL-17A immunity.To determine whether SAA causes neutrophilic inflammation by IL-17A-dependent mechanisms.The relationship between SAA and neutrophils was investigated in lung sections from patients with COPD and a chronic mouse model of SAA exposure. A neutralizing antibody to IL-17A was used to block SAA responses in vivo, and a cell-sorting strategy was used to identify cellular sources.SAA mRNA expression was positively associated with tissue neutrophils in COPD (P < 0.05). SAA predominately promoted expression of the TH17 polarizing cytokine IL-6, which was opposed by 15-epi-lipoxin A4, a counter-regulatory mediator, and ALX/FPR2 ligand. SAA-induced inflammation was markedly reduced by a neutralizing antibody to IL-17A in vivo. Cellular sources of IL-17A induced by SAA include CD4(+) T cells, γδ T cells, and an Epcam(+)CD45(-) population enriched for epithelial cells. SAA promotes expression of IL-17A in γδ T cells and this innate cell proportionally expressed higher levels of IL-17A transcript than CD4(+) T cells or epithelial cells.The SAA-IL-17A axis represents an important innate defense network that may underlie persistent neutrophilic airway inflammation in COPD and modulating the ALX/FPR2 receptor represents a novel approach to targeting aberrant IL-17A-mediated lung immunity." @default.
• W2125302694 created "2016-06-24" @default.
• W2125302694 creator A5008084743 @default.
• W2125302694 creator A5019519742 @default.
• W2125302694 creator A5036363614 @default.
• W2125302694 creator A5040119940 @default.
• W2125302694 creator A5050132863 @default.
• W2125302694 creator A5060211723 @default.
• W2125302694 creator A5069889145 @default.
• W2125302694 creator A5076011525 @default.
• W2125302694 creator A5077920127 @default.
• W2125302694 creator A5079475266 @default.
• W2125302694 date "2013-07-15" @default.
• W2125302694 modified "2023-10-03" @default.
• W2125302694 title "Serum Amyloid A Promotes Lung Neutrophilia by Increasing IL-17A Levels in the Mucosa and γδ T Cells" @default.
• W2125302694 cites W1569083792 @default.
• W2125302694 cites W1969944763 @default.
• W2125302694 cites W1974972293 @default.
• W2125302694 cites W1999128589 @default.
• W2125302694 cites W2014913358 @default.
• W2125302694 cites W2015677100 @default.
• W2125302694 cites W2038871743 @default.
• W2125302694 cites W2044433987 @default.
• W2125302694 cites W2046165350 @default.
• W2125302694 cites W2066344383 @default.
• W2125302694 cites W2070619903 @default.
• W2125302694 cites W2074277275 @default.
• W2125302694 cites W2090051914 @default.
• W2125302694 cites W2091588921 @default.
• W2125302694 cites W2095936428 @default.
• W2125302694 cites W2107369528 @default.
• W2125302694 cites W2110187123 @default.
• W2125302694 cites W2110681571 @default.
• W2125302694 cites W2110947112 @default.
• W2125302694 cites W2117837864 @default.
• W2125302694 cites W2120817194 @default.
• W2125302694 cites W2120970141 @default.
• W2125302694 cites W2127854030 @default.
• W2125302694 cites W2130959939 @default.
• W2125302694 cites W2131896212 @default.
• W2125302694 cites W2132342511 @default.
• W2125302694 cites W2141888996 @default.
• W2125302694 cites W2145466675 @default.
• W2125302694 cites W2150805904 @default.
• W2125302694 cites W2159269876 @default.
• W2125302694 cites W2160883911 @default.
• W2125302694 cites W2162099891 @default.
• W2125302694 cites W2162918753 @default.
• W2125302694 cites W2166505581 @default.
• W2125302694 doi "https://doi.org/10.1164/rccm.201211-2139oc" @default.
• W2125302694 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3778755" @default.
• W2125302694 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23627303" @default.
• W2125302694 hasPublicationYear "2013" @default.
• W2125302694 type Work @default.
• W2125302694 sameAs 2125302694 @default.
• W2125302694 citedByCount "55" @default.
• W2125302694 countsByYear W21253026942013 @default.
• W2125302694 countsByYear W21253026942014 @default.
• W2125302694 countsByYear W21253026942015 @default.
• W2125302694 countsByYear W21253026942016 @default.
• W2125302694 countsByYear W21253026942017 @default.
• W2125302694 countsByYear W21253026942018 @default.
• W2125302694 countsByYear W21253026942019 @default.
• W2125302694 countsByYear W21253026942020 @default.
• W2125302694 countsByYear W21253026942021 @default.
• W2125302694 countsByYear W21253026942022 @default.
• W2125302694 countsByYear W21253026942023 @default.
• W2125302694 crossrefType "journal-article" @default.
• W2125302694 hasAuthorship W2125302694A5008084743 @default.
• W2125302694 hasAuthorship W2125302694A5019519742 @default.
• W2125302694 hasAuthorship W2125302694A5036363614 @default.
• W2125302694 hasAuthorship W2125302694A5040119940 @default.
• W2125302694 hasAuthorship W2125302694A5050132863 @default.
• W2125302694 hasAuthorship W2125302694A5060211723 @default.
• W2125302694 hasAuthorship W2125302694A5069889145 @default.
• W2125302694 hasAuthorship W2125302694A5076011525 @default.
• W2125302694 hasAuthorship W2125302694A5077920127 @default.
• W2125302694 hasAuthorship W2125302694A5079475266 @default.
• W2125302694 hasBestOaLocation W21253026942 @default.
• W2125302694 hasConcept C203014093 @default.
• W2125302694 hasConcept C2776914184 @default.
• W2125302694 hasConcept C2777802486 @default.
• W2125302694 hasConcept C2778690821 @default.
• W2125302694 hasConcept C47348012 @default.
• W2125302694 hasConcept C55359608 @default.
• W2125302694 hasConcept C71924100 @default.
• W2125302694 hasConceptScore W2125302694C203014093 @default.
• W2125302694 hasConceptScore W2125302694C2776914184 @default.
• W2125302694 hasConceptScore W2125302694C2777802486 @default.
• W2125302694 hasConceptScore W2125302694C2778690821 @default.
• W2125302694 hasConceptScore W2125302694C47348012 @default.
• W2125302694 hasConceptScore W2125302694C55359608 @default.
• W2125302694 hasConceptScore W2125302694C71924100 @default.
• W2125302694 hasIssue "2" @default.
• W2125302694 hasLocation W21253026941 @default.
• W2125302694 hasLocation W21253026942 @default.
• W2125302694 hasLocation W21253026943 @default.
• W2125302694 hasLocation W21253026944 @default.

• next