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• W2125328211 startingPage "L991" @default.
• W2125328211 abstract "Diminished lung function, indicated by a low forced expiratory volume in one second (FEV 1 ), and short physical stature, predict early mortality from all causes, including cardiovascular, among smokers and never smokers. The basis for these associations is unclear, and, it is not known if there is a pulmonary morphological component to the relationship between low FEV 1 and early death in a general population. Some apolipoprotein E genotypes also predict atherosclerosis and early mortality. These considerations led us to examine the Apoe tm1Unc (Apoe) mouse, in which the apolipoprotein E gene is deleted, and that develops dyslipidemia, atherosclerosis at an early age, and has a shorter life span than the founder wild-type (wt) strain. We asked if Apoe mice have a morphological or functional pulmonary phenotype. We measured the size, number, and surface area of pulmonary gas-exchange units (alveoli) and mechanical properties of the lung. Compared with wt mice, Apoe mice had: 1) diminished developmental alveologenesis, 2) increased airway resistance in early adulthood, 3) high lung volume and high dynamic and static compliance in later adulthood, 4) more rapid loss of lung recoil with age, and 5) were less long than wt mice. These findings in mice indicate the association of a low FEV 1 with early death in humans may have developmental, and accelerated ageing, related pulmonary components, and that dietary, genetic, or dietary and genetic influences, on lipid metabolism may be an upstream cause of inflammation and oxidative stress, currently considered to be major risk factors for COPD." @default.
• W2125328211 created "2016-06-24" @default.
• W2125328211 creator A5044860668 @default.
• W2125328211 creator A5056790015 @default.
• W2125328211 date "2008-05-01" @default.
• W2125328211 modified "2023-10-01" @default.
• W2125328211 title "Apoe^{<i>tm1Unc</i>} mice have impaired alveologenesis, low lung function, and rapid loss of lung function" @default.
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• W2125328211 doi "https://doi.org/10.1152/ajplung.00013.2008" @default.
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