Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125332209> ?p ?o ?g. }
- W2125332209 endingPage "24" @default.
- W2125332209 startingPage "11" @default.
- W2125332209 abstract "Most common diseases and quantitative traits are heritable: determined in part by genetic variation within the population. The inheritance is typically polygenic in that combined effects of variants in numerous genes, plus nongenetic factors, determine outcome. The genes influencing common disease and quantitative traits remained largely unknown until the implementation in 2006 of genome-wide association (GWA) studies that comprehensively surveyed common genetic variation (frequency >5%). By 2010, GWA studies identified >1,000 genetic variants for polygenic traits. Typically, these variants together account for a modest fraction (10%–30%) of heritability, but they have highlighted genes in both known and new biological pathways and genes of unknown function. This initial effort prefigures new studies aimed at rarer variation and decades of functional work to decipher newly glimpsed biology. The greatest impact of GWA studies may not be in predictive medicine but rather in the development over the next decades of therapies based on novel biological insights." @default.
- W2125332209 created "2016-06-24" @default.
- W2125332209 creator A5001552586 @default.
- W2125332209 creator A5063027600 @default.
- W2125332209 date "2011-02-18" @default.
- W2125332209 modified "2023-10-06" @default.
- W2125332209 title "Genome-Wide Association Studies: Results from the First Few Years and Potential Implications for Clinical Medicine" @default.
- W2125332209 cites W1499959019 @default.
- W2125332209 cites W1546792714 @default.
- W2125332209 cites W1838763289 @default.
- W2125332209 cites W1944558458 @default.
- W2125332209 cites W1963639770 @default.
- W2125332209 cites W1963673462 @default.
- W2125332209 cites W1968165696 @default.
- W2125332209 cites W1979216961 @default.
- W2125332209 cites W1980991473 @default.
- W2125332209 cites W1981714996 @default.
- W2125332209 cites W1982875955 @default.
- W2125332209 cites W1985849948 @default.
- W2125332209 cites W1994664175 @default.
- W2125332209 cites W1995015222 @default.
- W2125332209 cites W1998641738 @default.
- W2125332209 cites W2006423274 @default.
- W2125332209 cites W2009588715 @default.
- W2125332209 cites W2012020901 @default.
- W2125332209 cites W2014077667 @default.
- W2125332209 cites W2015849111 @default.
- W2125332209 cites W2020040634 @default.
- W2125332209 cites W2022609707 @default.
- W2125332209 cites W2023455695 @default.
- W2125332209 cites W2025133978 @default.
- W2125332209 cites W2025143098 @default.
- W2125332209 cites W2025328309 @default.
- W2125332209 cites W2025471227 @default.
- W2125332209 cites W2036308544 @default.
- W2125332209 cites W2036329920 @default.
- W2125332209 cites W2037590835 @default.
- W2125332209 cites W2039608769 @default.
- W2125332209 cites W2041467022 @default.
- W2125332209 cites W2042103448 @default.
- W2125332209 cites W2042729575 @default.
- W2125332209 cites W2044100831 @default.
- W2125332209 cites W2047923046 @default.
- W2125332209 cites W2048755332 @default.
- W2125332209 cites W2065218625 @default.
- W2125332209 cites W2065435420 @default.
- W2125332209 cites W2068700927 @default.
- W2125332209 cites W2070879341 @default.
- W2125332209 cites W2071336935 @default.
- W2125332209 cites W2074754379 @default.
- W2125332209 cites W2075396092 @default.
- W2125332209 cites W2079501979 @default.
- W2125332209 cites W2082122713 @default.
- W2125332209 cites W2083283348 @default.
- W2125332209 cites W2087036932 @default.
- W2125332209 cites W2092325965 @default.
- W2125332209 cites W2097660065 @default.
- W2125332209 cites W2098597355 @default.
- W2125332209 cites W2099610622 @default.
- W2125332209 cites W2100443415 @default.
- W2125332209 cites W2106294125 @default.
- W2125332209 cites W2108963851 @default.
- W2125332209 cites W2109235725 @default.
- W2125332209 cites W2109529720 @default.
- W2125332209 cites W2109899118 @default.
- W2125332209 cites W2110343195 @default.
- W2125332209 cites W2113784410 @default.
- W2125332209 cites W2115623748 @default.
- W2125332209 cites W2115801316 @default.
- W2125332209 cites W2117446594 @default.
- W2125332209 cites W2118192748 @default.
- W2125332209 cites W2119279196 @default.
- W2125332209 cites W2121678970 @default.
- W2125332209 cites W2122031852 @default.
- W2125332209 cites W2125895642 @default.
- W2125332209 cites W2126415810 @default.
- W2125332209 cites W2134783591 @default.
- W2125332209 cites W2136078375 @default.
- W2125332209 cites W2136140188 @default.
- W2125332209 cites W2137249087 @default.
- W2125332209 cites W2141642891 @default.
- W2125332209 cites W2144601878 @default.
- W2125332209 cites W2147111825 @default.
- W2125332209 cites W2147888023 @default.
- W2125332209 cites W2149813409 @default.
- W2125332209 cites W2152435464 @default.
- W2125332209 cites W2152664025 @default.
- W2125332209 cites W2154238506 @default.
- W2125332209 cites W2154877797 @default.
- W2125332209 cites W2155496693 @default.
- W2125332209 cites W2155644892 @default.
- W2125332209 cites W2155829072 @default.
- W2125332209 cites W2158822657 @default.
- W2125332209 cites W2158944369 @default.
- W2125332209 cites W2161935988 @default.
- W2125332209 cites W2161998322 @default.
- W2125332209 cites W2162212014 @default.
- W2125332209 cites W2164716330 @default.