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• W2125335785 abstract "The effect of application of short, intense electric pulses on tumor blood volume was investigated using albumin-(Gd-DTPA)30 contrast-enhanced magnetic resonance imaging (MRI). One of paired SA-1 fibrosarcoma tumors implanted in each flank of A/J mice was treated with electric pulses. MRI was performed dynamically before and after intravenous administration of albumin-(Gd-DTPA)30 (0.02 mmol Gd/kg), and fractional tumor blood volume was estimated. MRI images of tumors exposed to electric pulses showed no enhancement at 30 min after injection of albu-min-(Gd-DTPA)30. However, marked enhancement was observed in paired tumors of the same mice that were not exposed to electric pulses. A significant difference in blood volume was observed between nontreated tumors and tumors treated with electric pulses. Application of electric pulses to the tumors significantly reduced blood volume in the tumors. Therefore, through a reduction in tumor blood volume, electric pulses may, besides producing electroporation of cells, exert antitumor effectiveness by entrapping drugs within the tumors." @default.
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• W2125335785 date "1998-01-01" @default.
• W2125335785 modified "2023-10-03" @default.
• W2125335785 title "Contrast Enhanced MRI Assessment of Tumor Blood Volume After Application of Electric Pulses" @default.
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• W2125335785 doi "https://doi.org/10.3109/15368379809022574" @default.
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