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- W2125344567 abstract "NOD2 variants have been identified to be a susceptibility factor for Crohn's disease. The NOD2 protein is an intracellular sensor of the bacterial wall product muramyl dipeptide (MDP) and activates the transcription factor NF-kappaB upon MDP-binding. NOD2 variants are associated with reduced NF-kappaB activation and reduced production of epithelial derived antibacterial peptides such as defensins. A reduced expression of defensins is described and found in patients with Crohn's disease and ulcerative colitis especially when NOD2 variants are present. Furthermore recent evidence from mouse models suggests that the ability of intestinal epithelial cells to activate NF-kappaB upon bacterial stimulation protects from mucosal inflammation. Taken together these data indicate that NOD2 mediated NF-kappaB activation, subsequent induction of anti-microbial peptides such as defensins and induction of cytokine expression are essential for the function of the intestinal barrier and for the prevention of bacterial translocation. The data indicate why a defect in the induction of this acute defense response is associated with chronic inflammation. Invading bacteria that cannot be readily detected and eliminated may start a backup mechanism of inflammation finally resulting in chronic inflammatory reaction followed by further impairment of the mucosal barrier." @default.
- W2125344567 created "2016-06-24" @default.
- W2125344567 creator A5058012401 @default.
- W2125344567 date "2007-12-01" @default.
- W2125344567 modified "2023-10-03" @default.
- W2125344567 title "The effects of NOD2/CARD15 mutations on the function of the intestinal barrier" @default.
- W2125344567 cites W1492384889 @default.
- W2125344567 cites W1512595753 @default.
- W2125344567 cites W1514224413 @default.
- W2125344567 cites W1537503588 @default.
- W2125344567 cites W1642457845 @default.
- W2125344567 cites W1670573097 @default.
- W2125344567 cites W1883663359 @default.
- W2125344567 cites W1965004275 @default.
- W2125344567 cites W1967946528 @default.
- W2125344567 cites W1968112772 @default.
- W2125344567 cites W1969767037 @default.
- W2125344567 cites W1975100189 @default.
- W2125344567 cites W1975870295 @default.
- W2125344567 cites W1978972720 @default.
- W2125344567 cites W1979324447 @default.
- W2125344567 cites W1988694882 @default.
- W2125344567 cites W1990941798 @default.
- W2125344567 cites W1995321760 @default.
- W2125344567 cites W1998395322 @default.
- W2125344567 cites W2005584838 @default.
- W2125344567 cites W2010713573 @default.
- W2125344567 cites W2011749939 @default.
- W2125344567 cites W2012812407 @default.
- W2125344567 cites W2013329696 @default.
- W2125344567 cites W2016277483 @default.
- W2125344567 cites W2021706207 @default.
- W2125344567 cites W2022099492 @default.
- W2125344567 cites W2026028158 @default.
- W2125344567 cites W2027586189 @default.
- W2125344567 cites W2040780867 @default.
- W2125344567 cites W2041607290 @default.
- W2125344567 cites W2042675697 @default.
- W2125344567 cites W2043667001 @default.
- W2125344567 cites W2044481171 @default.
- W2125344567 cites W2047956396 @default.
- W2125344567 cites W2049349880 @default.
- W2125344567 cites W2050316462 @default.
- W2125344567 cites W2051016124 @default.
- W2125344567 cites W2051804005 @default.
- W2125344567 cites W2052127995 @default.
- W2125344567 cites W2052798287 @default.
- W2125344567 cites W2054493318 @default.
- W2125344567 cites W2055969389 @default.
- W2125344567 cites W2056428779 @default.
- W2125344567 cites W2057447694 @default.
- W2125344567 cites W2060042651 @default.
- W2125344567 cites W2061606433 @default.
- W2125344567 cites W2065605458 @default.
- W2125344567 cites W2066201784 @default.
- W2125344567 cites W2068233027 @default.
- W2125344567 cites W2069155370 @default.
- W2125344567 cites W2070413937 @default.
- W2125344567 cites W2071366086 @default.
- W2125344567 cites W2075583035 @default.
- W2125344567 cites W2076872340 @default.
- W2125344567 cites W2086607027 @default.
- W2125344567 cites W2089152744 @default.
- W2125344567 cites W2091457240 @default.
- W2125344567 cites W2092276464 @default.
- W2125344567 cites W2095457402 @default.
- W2125344567 cites W2095464081 @default.
- W2125344567 cites W2110372095 @default.
- W2125344567 cites W2110521139 @default.
- W2125344567 cites W2111900042 @default.
- W2125344567 cites W2119284252 @default.
- W2125344567 cites W2126358235 @default.
- W2125344567 cites W2126678086 @default.
- W2125344567 cites W2128175802 @default.
- W2125344567 cites W2132087209 @default.
- W2125344567 cites W2135100507 @default.
- W2125344567 cites W2146600962 @default.
- W2125344567 cites W2150771431 @default.
- W2125344567 cites W2152532561 @default.
- W2125344567 cites W2153130127 @default.
- W2125344567 cites W2155025594 @default.
- W2125344567 cites W2163489226 @default.
- W2125344567 cites W2166710590 @default.
- W2125344567 cites W4231022815 @default.
- W2125344567 doi "https://doi.org/10.1016/j.crohns.2007.08.008" @default.
- W2125344567 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21172185" @default.
- W2125344567 hasPublicationYear "2007" @default.
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