FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125367046> ?p ?o ?g. }

• W2125367046 endingPage "117" @default.
• W2125367046 startingPage "95" @default.
• W2125367046 abstract "Approximately 90% of all ophthalmic drug formulations are now applied as eye-drops. While eye-drops are convenient and well accepted by patients, about 95% of the drug contained in the drops is lost due to absorption through the conjunctiva or through the tear drainage. A major fraction of the drug eventually enters the blood stream and may cause side effects. The drug loss and the side effects can be minimized by using disposable soft contact lenses for ophthalmic drug delivery. The essential idea is to encapsulate the ophthalmic drug formulations in nanoparticles, and disperse these drug-laden particles in the lens material. Upon insertion into the eye, the lens will slowly release the drug into the pre lens (the film between the air and the lens) and the post-lens (the film between the cornea and the lens) tear films, and thus provide drug delivery for extended periods of time. This paper focuses on dispersing stabilized microemulsion drops in poly-2-hydroxyethyl methacrylate (p-HEMA) hydrogels. The results of this study show that the p-HEMA gels loaded with a microemulsion that is stabilized with a silica shell are transparent and that these gels release drugs for a period of over 8 days. Contact lenses made of microemulsion-laden gels are expected to deliver drugs at therapeutic levels for a few days. The delivery rates can be tailored by controlling the particle and the drug loading. It may be possible to use this system for both therapeutic drug delivery to eyes and the provision of lubricants to alleviate eye problems prevalent in extended lens wear." @default.
• W2125367046 created "2016-06-24" @default.
• W2125367046 creator A5030939550 @default.
• W2125367046 creator A5032289092 @default.
• W2125367046 date "2005-03-01" @default.
• W2125367046 modified "2023-10-08" @default.
• W2125367046 title "Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle" @default.
• W2125367046 cites W1601465165 @default.
• W2125367046 cites W1964883353 @default.
• W2125367046 cites W1966471061 @default.
• W2125367046 cites W1970171221 @default.
• W2125367046 cites W1985393355 @default.
• W2125367046 cites W1986180285 @default.
• W2125367046 cites W1996627406 @default.
• W2125367046 cites W2007067975 @default.
• W2125367046 cites W2032512620 @default.
• W2125367046 cites W2053677988 @default.
• W2125367046 cites W2068433569 @default.
• W2125367046 cites W2098298726 @default.
• W2125367046 cites W2115200053 @default.
• W2125367046 cites W2120385358 @default.
• W2125367046 cites W2135018654 @default.
• W2125367046 cites W2142956278 @default.
• W2125367046 cites W2146573904 @default.
• W2125367046 cites W2165412671 @default.
• W2125367046 cites W82380869 @default.
• W2125367046 doi "https://doi.org/10.1016/j.ijpharm.2004.11.033" @default.
• W2125367046 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15725557" @default.
• W2125367046 hasPublicationYear "2005" @default.
• W2125367046 type Work @default.
• W2125367046 sameAs 2125367046 @default.
• W2125367046 citedByCount "244" @default.
• W2125367046 countsByYear W21253670462012 @default.
• W2125367046 countsByYear W21253670462013 @default.
• W2125367046 countsByYear W21253670462014 @default.
• W2125367046 countsByYear W21253670462015 @default.
• W2125367046 countsByYear W21253670462016 @default.
• W2125367046 countsByYear W21253670462017 @default.
• W2125367046 countsByYear W21253670462018 @default.
• W2125367046 countsByYear W21253670462019 @default.
• W2125367046 countsByYear W21253670462020 @default.
• W2125367046 countsByYear W21253670462021 @default.
• W2125367046 countsByYear W21253670462022 @default.
• W2125367046 countsByYear W21253670462023 @default.
• W2125367046 crossrefType "journal-article" @default.
• W2125367046 hasAuthorship W2125367046A5030939550 @default.
• W2125367046 hasAuthorship W2125367046A5032289092 @default.
• W2125367046 hasConcept C118487528 @default.
• W2125367046 hasConcept C120665830 @default.
• W2125367046 hasConcept C121332964 @default.
• W2125367046 hasConcept C132050475 @default.
• W2125367046 hasConcept C136229726 @default.
• W2125367046 hasConcept C15336307 @default.
• W2125367046 hasConcept C15920480 @default.
• W2125367046 hasConcept C159985019 @default.
• W2125367046 hasConcept C171250308 @default.
• W2125367046 hasConcept C185592680 @default.
• W2125367046 hasConcept C190119865 @default.
• W2125367046 hasConcept C192562407 @default.
• W2125367046 hasConcept C2776882836 @default.
• W2125367046 hasConcept C2778140322 @default.
• W2125367046 hasConcept C2778837293 @default.
• W2125367046 hasConcept C2779820397 @default.
• W2125367046 hasConcept C2780035454 @default.
• W2125367046 hasConcept C2986805488 @default.
• W2125367046 hasConcept C43617362 @default.
• W2125367046 hasConcept C521977710 @default.
• W2125367046 hasConcept C55493867 @default.
• W2125367046 hasConcept C58226133 @default.
• W2125367046 hasConcept C71924100 @default.
• W2125367046 hasConcept C77281830 @default.
• W2125367046 hasConcept C98274493 @default.
• W2125367046 hasConceptScore W2125367046C118487528 @default.
• W2125367046 hasConceptScore W2125367046C120665830 @default.
• W2125367046 hasConceptScore W2125367046C121332964 @default.
• W2125367046 hasConceptScore W2125367046C132050475 @default.
• W2125367046 hasConceptScore W2125367046C136229726 @default.
• W2125367046 hasConceptScore W2125367046C15336307 @default.
• W2125367046 hasConceptScore W2125367046C15920480 @default.
• W2125367046 hasConceptScore W2125367046C159985019 @default.
• W2125367046 hasConceptScore W2125367046C171250308 @default.
• W2125367046 hasConceptScore W2125367046C185592680 @default.
• W2125367046 hasConceptScore W2125367046C190119865 @default.
• W2125367046 hasConceptScore W2125367046C192562407 @default.
• W2125367046 hasConceptScore W2125367046C2776882836 @default.
• W2125367046 hasConceptScore W2125367046C2778140322 @default.
• W2125367046 hasConceptScore W2125367046C2778837293 @default.
• W2125367046 hasConceptScore W2125367046C2779820397 @default.
• W2125367046 hasConceptScore W2125367046C2780035454 @default.
• W2125367046 hasConceptScore W2125367046C2986805488 @default.
• W2125367046 hasConceptScore W2125367046C43617362 @default.
• W2125367046 hasConceptScore W2125367046C521977710 @default.
• W2125367046 hasConceptScore W2125367046C55493867 @default.
• W2125367046 hasConceptScore W2125367046C58226133 @default.
• W2125367046 hasConceptScore W2125367046C71924100 @default.
• W2125367046 hasConceptScore W2125367046C77281830 @default.
• W2125367046 hasConceptScore W2125367046C98274493 @default.
• W2125367046 hasIssue "1-2" @default.

• next