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- W2125367087 abstract "To improve the therapeutic efficacy of 20(s)-camptothecin (CPT) polymeric drugs containing CPT have been designed. A new CPT-conjugate, 3,6-endo-methylene-1,2,3,6-tetrahydrophthalimidoacetamidoglycine camptothecin ester (ETPA-gly-CPT), was synthesized by linking its hydroxyl group to the phthalimido monomer through a glycine–glycine spacer. Its homo- and copolymer with acrylic acid (AA) were prepared by photopolymerization using 2,2-dimethoxy-2-phenylacetophenone (DMP) as a photoinitiator. The monomer and its polymers were characterized by IR, 1H- and 13C-NMR spectra. The ETPA-gly-CPT content in poly(ETPA-gly-CPT-co-AA) obtained by elemental analysis was 40 wt.%. The number-average molecular weights of the polymers determined by gel permeation chromatography were as follows: Mn=15,000 for poly(ETPA-gly-CPT), Mn=18,700 for poly(ETPA-gly-CPT-co-AA). The IC50 values of ETPA-gly-CPT and its polymers against cancer cells were much larger than that of CPT." @default.
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- W2125367087 date "2004-07-01" @default.
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- W2125367087 title "Synthesis and in vitro antitumor activity of phthalimide-based polymers containing camptothecin" @default.
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- W2125367087 doi "https://doi.org/10.1016/j.eurpolymj.2004.01.035" @default.
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