Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125408508> ?p ?o ?g. }
- W2125408508 endingPage "25" @default.
- W2125408508 startingPage "13" @default.
- W2125408508 abstract "Spontaneous dissection of the human thoracic aorta is responsible for significant morbidity and mortality, yet this devastating biomechanical failure process remains poorly understood. In this paper, we present finite element simulations that support a new hypothesis for the initiation of aortic dissections that is motivated by extensive histopathological observations. Specifically, our parametric simulations show that the pooling of glycosaminoglycans/proteoglycans that is singularly characteristic of the compromised thoracic aorta in aneurysms and dissections can lead to significant stress concentrations and intra-lamellar Donnan swelling pressures. We submit that these localized increases in intramural stress may be sufficient both to disrupt the normal cell-matrix interactions that are fundamental to aortic homeostasis and to delaminate the layered microstructure of the aortic wall and thereby initiate dissection. Hence, pathologic pooling of glycosaminoglycans/proteoglycans within the medial layer of the thoracic aortic should be considered as a possible target for clinical intervention." @default.
- W2125408508 created "2016-06-24" @default.
- W2125408508 creator A5014180482 @default.
- W2125408508 creator A5022022053 @default.
- W2125408508 creator A5031271799 @default.
- W2125408508 date "2013-03-15" @default.
- W2125408508 modified "2023-10-08" @default.
- W2125408508 title "Biomechanical roles of medial pooling of glycosaminoglycans in thoracic aortic dissection" @default.
- W2125408508 cites W1500831274 @default.
- W2125408508 cites W15877150 @default.
- W2125408508 cites W1965174699 @default.
- W2125408508 cites W1966795228 @default.
- W2125408508 cites W1967794479 @default.
- W2125408508 cites W1976056802 @default.
- W2125408508 cites W1976950008 @default.
- W2125408508 cites W1977604129 @default.
- W2125408508 cites W1981737207 @default.
- W2125408508 cites W1982229143 @default.
- W2125408508 cites W1986105178 @default.
- W2125408508 cites W1994580245 @default.
- W2125408508 cites W1999728731 @default.
- W2125408508 cites W2000028229 @default.
- W2125408508 cites W2003380614 @default.
- W2125408508 cites W2011247521 @default.
- W2125408508 cites W2011931614 @default.
- W2125408508 cites W2017950984 @default.
- W2125408508 cites W2018307323 @default.
- W2125408508 cites W2018784507 @default.
- W2125408508 cites W2018831946 @default.
- W2125408508 cites W2020485149 @default.
- W2125408508 cites W2021089517 @default.
- W2125408508 cites W2021989452 @default.
- W2125408508 cites W2025790361 @default.
- W2125408508 cites W2030027772 @default.
- W2125408508 cites W2036954913 @default.
- W2125408508 cites W2041009444 @default.
- W2125408508 cites W2041938961 @default.
- W2125408508 cites W2057125848 @default.
- W2125408508 cites W2057977402 @default.
- W2125408508 cites W2061049870 @default.
- W2125408508 cites W2067017355 @default.
- W2125408508 cites W2072648109 @default.
- W2125408508 cites W2073788830 @default.
- W2125408508 cites W2077510229 @default.
- W2125408508 cites W2080113459 @default.
- W2125408508 cites W2081189235 @default.
- W2125408508 cites W2083757081 @default.
- W2125408508 cites W2092198701 @default.
- W2125408508 cites W2100139763 @default.
- W2125408508 cites W2107675829 @default.
- W2125408508 cites W2111740090 @default.
- W2125408508 cites W2112123157 @default.
- W2125408508 cites W2113317598 @default.
- W2125408508 cites W2114115666 @default.
- W2125408508 cites W2116651010 @default.
- W2125408508 cites W2122726412 @default.
- W2125408508 cites W2123736213 @default.
- W2125408508 cites W2124772958 @default.
- W2125408508 cites W2128168840 @default.
- W2125408508 cites W2132665343 @default.
- W2125408508 cites W2137502064 @default.
- W2125408508 cites W2147828329 @default.
- W2125408508 cites W2149335377 @default.
- W2125408508 cites W2150044334 @default.
- W2125408508 cites W2150838305 @default.
- W2125408508 cites W2151447106 @default.
- W2125408508 cites W2156559614 @default.
- W2125408508 cites W2156815041 @default.
- W2125408508 cites W2158121693 @default.
- W2125408508 cites W2159351650 @default.
- W2125408508 cites W2165020996 @default.
- W2125408508 cites W2418584829 @default.
- W2125408508 cites W2480924511 @default.
- W2125408508 cites W7015111 @default.
- W2125408508 doi "https://doi.org/10.1007/s10237-013-0482-3" @default.
- W2125408508 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3918738" @default.
- W2125408508 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23494585" @default.
- W2125408508 hasPublicationYear "2013" @default.
- W2125408508 type Work @default.
- W2125408508 sameAs 2125408508 @default.
- W2125408508 citedByCount "89" @default.
- W2125408508 countsByYear W21254085082013 @default.
- W2125408508 countsByYear W21254085082014 @default.
- W2125408508 countsByYear W21254085082015 @default.
- W2125408508 countsByYear W21254085082016 @default.
- W2125408508 countsByYear W21254085082017 @default.
- W2125408508 countsByYear W21254085082018 @default.
- W2125408508 countsByYear W21254085082019 @default.
- W2125408508 countsByYear W21254085082020 @default.
- W2125408508 countsByYear W21254085082021 @default.
- W2125408508 countsByYear W21254085082022 @default.
- W2125408508 countsByYear W21254085082023 @default.
- W2125408508 crossrefType "journal-article" @default.
- W2125408508 hasAuthorship W2125408508A5014180482 @default.
- W2125408508 hasAuthorship W2125408508A5022022053 @default.
- W2125408508 hasAuthorship W2125408508A5031271799 @default.
- W2125408508 hasBestOaLocation W21254085082 @default.
- W2125408508 hasConcept C105702510 @default.