Matches in SemOpenAlex for { <https://semopenalex.org/work/W2125421120> ?p ?o ?g. }
- W2125421120 endingPage "829" @default.
- W2125421120 startingPage "811" @default.
- W2125421120 abstract "In vivo, in vitro and computational studies were used to investigate the impact of the synaptic background activity observed in neocortical neurons in vivo. We simulated background activity in vitro using two stochastic Ornstein-Uhlenbeck processes describing glutamatergic and GABAergic synaptic conductances, which were injected into a cell in real time using the dynamic clamp technique. With parameters chosen to mimic in vivo conditions, layer 5 rat prefrontal cortex cells recorded in vitro were depolarized by about 15 mV, their membrane fluctuated with a S.D. of about 4 mV, their input resistances decreased five-fold, their spontaneous firing had a high coefficient of variation and an average firing rate of about 5–10 Hz. Brief changes in the variance of the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) synaptic conductance fluctuations induced time-locked spiking without significantly changing the average membrane potential of the cell. These transients mimicked increases in the correlation of excitatory inputs. Background activity was highly effective in modulating the firing-rate/current curve of the cell: the variance of the simulated γ-aminobutyric acid (GABA) and AMPA conductances individually set the input/output gain, the mean excitatory and inhibitory conductances set the working point, and the mean inhibitory conductance controlled the input resistance. An average ratio of inhibitory to excitatory mean conductances close to 4 was optimal in generating membrane potential fluctuations with high coefficients of variation. We conclude that background synaptic activity can dynamically modulate the input/output properties of individual neocortical neurons in vivo." @default.
- W2125421120 created "2016-06-24" @default.
- W2125421120 creator A5003609825 @default.
- W2125421120 creator A5005630390 @default.
- W2125421120 creator A5022027790 @default.
- W2125421120 creator A5044141636 @default.
- W2125421120 date "2003-01-01" @default.
- W2125421120 modified "2023-10-16" @default.
- W2125421120 title "Synaptic background noise controls the input/output characteristics of single cells in an in vitro model of in vivo activity" @default.
- W2125421120 cites W1454096902 @default.
- W2125421120 cites W1619416921 @default.
- W2125421120 cites W1623755432 @default.
- W2125421120 cites W1825044724 @default.
- W2125421120 cites W1841807818 @default.
- W2125421120 cites W1859669881 @default.
- W2125421120 cites W1878427780 @default.
- W2125421120 cites W1904639934 @default.
- W2125421120 cites W1923658178 @default.
- W2125421120 cites W1928151192 @default.
- W2125421120 cites W1942615418 @default.
- W2125421120 cites W1949141612 @default.
- W2125421120 cites W1951749181 @default.
- W2125421120 cites W1967522734 @default.
- W2125421120 cites W1967973114 @default.
- W2125421120 cites W1976584289 @default.
- W2125421120 cites W1983877900 @default.
- W2125421120 cites W2017957151 @default.
- W2125421120 cites W2025687881 @default.
- W2125421120 cites W2032774941 @default.
- W2125421120 cites W2032776279 @default.
- W2125421120 cites W2034867646 @default.
- W2125421120 cites W2037835420 @default.
- W2125421120 cites W2037944537 @default.
- W2125421120 cites W2041444821 @default.
- W2125421120 cites W2042067913 @default.
- W2125421120 cites W2045063000 @default.
- W2125421120 cites W2045824109 @default.
- W2125421120 cites W2058035478 @default.
- W2125421120 cites W2062899906 @default.
- W2125421120 cites W2064617097 @default.
- W2125421120 cites W2068501389 @default.
- W2125421120 cites W2070159194 @default.
- W2125421120 cites W2073512103 @default.
- W2125421120 cites W2082354908 @default.
- W2125421120 cites W2090490936 @default.
- W2125421120 cites W2097274016 @default.
- W2125421120 cites W2105829350 @default.
- W2125421120 cites W2109387052 @default.
- W2125421120 cites W2117113597 @default.
- W2125421120 cites W2117120818 @default.
- W2125421120 cites W2122037734 @default.
- W2125421120 cites W2125311180 @default.
- W2125421120 cites W2125733184 @default.
- W2125421120 cites W2125988384 @default.
- W2125421120 cites W2130302656 @default.
- W2125421120 cites W2133769308 @default.
- W2125421120 cites W2138704896 @default.
- W2125421120 cites W2139789458 @default.
- W2125421120 cites W2139975927 @default.
- W2125421120 cites W2146288322 @default.
- W2125421120 cites W2146766016 @default.
- W2125421120 cites W2148452798 @default.
- W2125421120 cites W2150144034 @default.
- W2125421120 cites W2152016695 @default.
- W2125421120 cites W2152564840 @default.
- W2125421120 cites W2152896566 @default.
- W2125421120 cites W2154034179 @default.
- W2125421120 cites W2154323800 @default.
- W2125421120 cites W2156571346 @default.
- W2125421120 cites W2169075810 @default.
- W2125421120 cites W2170814877 @default.
- W2125421120 cites W2171074980 @default.
- W2125421120 cites W2171325791 @default.
- W2125421120 cites W2172274087 @default.
- W2125421120 cites W2172294131 @default.
- W2125421120 cites W4295831928 @default.
- W2125421120 doi "https://doi.org/10.1016/j.neuroscience.2003.08.027" @default.
- W2125421120 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2928821" @default.
- W2125421120 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14622924" @default.
- W2125421120 hasPublicationYear "2003" @default.
- W2125421120 type Work @default.
- W2125421120 sameAs 2125421120 @default.
- W2125421120 citedByCount "246" @default.
- W2125421120 countsByYear W21254211202012 @default.
- W2125421120 countsByYear W21254211202013 @default.
- W2125421120 countsByYear W21254211202014 @default.
- W2125421120 countsByYear W21254211202015 @default.
- W2125421120 countsByYear W21254211202016 @default.
- W2125421120 countsByYear W21254211202017 @default.
- W2125421120 countsByYear W21254211202018 @default.
- W2125421120 countsByYear W21254211202019 @default.
- W2125421120 countsByYear W21254211202020 @default.
- W2125421120 countsByYear W21254211202021 @default.
- W2125421120 countsByYear W21254211202022 @default.
- W2125421120 countsByYear W21254211202023 @default.
- W2125421120 crossrefType "journal-article" @default.
- W2125421120 hasAuthorship W2125421120A5003609825 @default.
- W2125421120 hasAuthorship W2125421120A5005630390 @default.